242 research outputs found
Actoxumab + bezlotoxumab combination: what promise for Clostridium difficile treatment?
No full textIntroduction: Clostridium difficile infection (CDI) is the most common healthcare-associated infection worldwide. As standard CDI antibiotic therapies can result in unacceptably high recurrence rates, novel therapeutic strategies for CDI are necessary. A recently emerged immunological therapy is a monoclonal antibody against C. difficile toxin B. Areas covered: In this review, the authors summarize the available pharmacological, preclinical, and clinical data for the CDI treatment based on anti-toxin A (actoxumab) and anti-toxin B (bezlotoxumab) human monoclonal antibodies (HuMabs), and discuss about the potentiality of a therapy that includes HuMab combined administration for CDI. Expert opinion: Although only bezlotoxumab is indicated to reduce recurrence of CDI, experimental studies using a combination of HuMabs actoxumab and bezlotoxumab have shown that bolstering the host immune response against both the C. difficile toxins may be effective in primary and secondary CDI prevention. Besides neutralizing both the key virulence factors, combination of two HuMabs could potentially offer an advantage for a yet to emerge C. difficile strain, which is a steady threat for patients at high risk of CDI. However, as actoxumab development was halted, passive immunotherapy with actoxumab/bezlotoxumab is actually impracticable. Future research will be needed to assess HuMab combination as a therapeutic strategy in clinical and microbiological cure of CDI
Sul ruolo dell'ombudsman nella tutela del diritto di accesso (e sulla concreta efficacia del rimedio) = The role of the Italian ombudsman when it intervenes to protect the access right (and the effectiveness of this as a remedy)
No full textNell’articolo, l’a. analizza il ruolo del difensore civico italiano nella tutela del diritto
di accesso documentale e civico, evidenziando le criticità che emergono (anche sul
piano processuale) dalla lettura delle norme che ne regolano l’azione. Nella parte
finale, l’a. dà conto dell’efficacia concreta del rimedio alla luce delle più recenti
relazioni annuali redatte dai difensori civici regionali.In the article, the author analyzes the italian ombudsman role when it intervenes to
protect the access right to documents. Critical issues that arise from the application of
the rules that govern its actions are also highlighted in the paper. In the latter part of
the paper, the author assesses the actual effectiveness of this as remedy, in light of the
most recent annual reports drafted by the italian ombudsmen
Violazione di legge formale - procedurale: brevi riflessioni in tema di dequotazione dei vizi e rapporti con l'art. 21 octies - L. 241/90
No full textAutorizzazione alla realizzazione di strutture sanitarie, verifica di compatibilità regionale e silenzio assenso tra pubbliche amministrazioni
No full textCon la sentenza in rassegna, il T.A.R. Puglia afferma che, nell’ambito del procedimento comunale prodromico alla emanazione dell’eventuale provvedimento di autorizzazione alla realizzazione di una struttura sanitaria, in caso di inerzia della Regione tenuta a effettuare la verifica di compatibilità, non trova applicazione l’art. 17-bis, L. n. 241/1990, perché le due amministrazioni (Comune e Regione) non si pongono in un rapporto di autorità concertante e concertata. Sebbene se ne condivida l’esito (si ritiene, infatti, che l’art. 17-bis, L. n. 241/1990 sia inapplicabile al rapporto de quo), la sentenza in commento lascia perplessi sotto il profilo argomentativo. In altre parole, sembra che il Collegio ben avrebbe potuto escludere l’applicabilità dell’art. 17-bis seguendo un altro tipo di ragionamento, anche alla luce di una recente giurisprudenza del Consiglio di Stato che è espressamente intervenuta sull’argomento
Appendice giurisprudenziale a Mari G., L’obbligo di provvedere e i rimedi preventivi e successivi alla relativa violazione (artt. 2 e 20 l. n. 241 del 1990 e s.m.i.)
No full text
Brevi note sull’obbligo di provvedere della p.A. alla luce del “nuovo” art. 2 della L. 7 agosto, 1990, n. 241
No full textSobolev embedding into BMO and weak- for 1-dimensional probability measure
No full textWe characterize rearrangement invariant spaces with respect to a suitable
one dimensional probability e.g. log-concave measure) such
that the Sobolev embedding into BMO space holds
where is the
space of functions with bounded mean oscillation with respect to . We
investigate the embedding in weak- too
Existence results for nonlinear elliptic equations related to Gauss measure in a limit case
No full textThe aim of this paper is to prove existence results for nonlinear
elliptic equations whose the prototype is −div (|u|^(p−2)u )= g φ in
a open subset Ω of R^n, , u = 0 on \partial Omega , where p ≥2, the function φ( x) =
(2π)^ (n/2) exp (−|x|^2 /2) is the density of Gauss measure and g \in L^1 (log L)^(1/2)
This condition on the function g is sharp in the class of Zygmund spaces
Sobolev embedding into BMO and weak-L ∞ for 1-dimensional probability measure.
No full textWe characterize rearrangement invariant spaces X with respect to a suitable 1-dimensional probability μ (e.g. log-concave measure) such that the Sobolev embedding
‖u‖BMO(R,μ)≤C(‖u′‖X+‖u‖L1(R,μ)) holds for any function u∈L1(R,μ), whose real-valued weakly derivative u′u′ belongs to X . Here BMO(R,μ) is the space of functions with bounded mean oscillation with respect to μ . We investigate the embedding in weak-L∞(R,μ), too
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