1,720,995 research outputs found
Hyper IgE syndrome : a case report
No full textBackground and aims: The hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, rash, and recurrent bacterial infections of the skin and lung. Methods: We report a case of a 13-year old boy from Sri-Lanka. The boy has been suffering from atopic dermatitis since first months of life, and from recurrent allergic asthma since the age of 2. Pustular lesions with a tendency toward formation of multiple abscesses appeared all from August 2011 and were always treated with antibiotic therapy. Results: In June 2012, the child was admitted to our department due to fever and abdominal pain that started 5 days prior to admission. Blood test results: PCR = 93,4 mg/L (normal value < 10 mg/L), Mycoplasma Pneumoniae serological Immunoglobulin (Ig) M positive, Ig E level = 10,428 UI/mL (normal value < 100 UI/mL). Mantoux test was negative. Chest X-ray showed a consolidation area, which looked like a pulmonary abscess. CT imaging confirmed the diagnosis. Clinical and radiological improvement was not achieved despite antibiotic treatment with ceftazidime and clarithromycin. The abscess was drained and Methicillin resistant (MRSA) Staphilococcus aureus was isolated. Considering the clinical features, IgE values and etiology of abscess, a diagnosis of Hyper-IgE syndrome was stated. Antibiotic therapy with vancomycin was started, and clinical condition improved. Identification of STAT3 mutation is still ongoing. Conclusion: complications of pulmonary infections are the most common causes of death in hyper-Ig E syndrome. Introduction of comprehensive treatment, including prophylaxis, decreases the recurrences
La comunicazione del rischio nei momenti di crisi nell’area della salute pubblica : aspetti teorico- pratici
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Management of Nonceliac Gluten Sensitivity by Gastroenterology Specialists : Data from an Italian Survey
Full text linkBackground and Aim. Nonceliac gluten sensitivity is syndrome characterized by symptoms disappearing after a gluten-free diet. Its existence is still argument of discussion among specialists. Our aim was to evaluate the knowledge about nonceliac gluten sensitivity among gastroenterology specialists. Methods. During October 2013 a questionnaire was sent through a medical newsletter to Italian gastroenterologists. Twelve questions investigated their knowledge on nonceliac gluten sensitivity, including their diagnostic and therapeutic approach. Results. A total of 212 gastroenterologists filled in the questionnaire. The 98.6% were aware of the existence of a syndrome called "nonceliac gluten sensitivity" and 77% believe in its existence. However, only 56% gave a correct definition of the term. The majority of specialists diagnosed gluten sensitive patients and the number of diagnoses was not statistically different from that of celiac disease. Moreover, a gluten-free diet was prescribed by 64% of the specialists and among them the 73% noted an increase of gluten sensitive patients attending their outpatient services. Conclusions. Our study indicated that most of the specialists recognize nonceliac gluten sensitivity and prescribe gluten-free diet, although 44% of the specialists are not able to give its correct definition; underlining the necessity of medical education on this topic is needed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
La notizia medico-scientifica e i media
No full textIn contrasto con la necessità del pubblico di avere sempre più informazioni sulla salute, spesso la relazione giornalisti-scienziati non appare facile per la complessita del metodo scientifico e del suo gerg
Complex rearrangement involving 9p deletion and duplication in a syndromic patient : Genotype/phenotype correlation and review of the literature
Full text linkWe describe a 7-year-old boy with a complex rearrangement involving the whole short arm of chromosome 9 defined by means of molecular cytogenetic techniques. The rearrangement is characterized by a 18.3Mb terminal deletion associated with the inverted duplication of the adjacent 21,5Mb region. The patient shows developmental delay, psychomotor retardation, hypotonia. Other typical features of 9p deletion (genital disorders, midface hypoplasia, long philtrum) and of the 9p duplication (brachycephaly, down slanting palpebral fissures and bulbous nasal tip) are present. Interestingly, he does not show trigonocephaly that is the most prominent dysmorphism associated with the deletion of the short arm of chromosome 9. Patient's phenotype and the underlying flanking opposite 9p imbalances are compared with that of reported patients and the proposed critical regions for 9p deletion and 9p duplication syndromes
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