2,228 research outputs found
Engineering estimation of the fatigue limit of wrought and defective additively manufactured metals for different load ratios
No full textAn empirical bi-parametric model based on the Vickers hardness HV and a proper microstructural length parameter, l, was proposed to estimate the fully reversed threshold-Stress Intensity Factor for long cracks of wrought and additively manufactured (AM) alloys. In this paper, the model has been extended to positive load ratios (R ≅ 0 and ≅ 0.5). Afterwards, experimental results generated from testing AM specimens containing natural defects were taken from the literature and were compared successfully with the estimation based on the El Haddad Smith Topper and the Atzori Lazzarin Meneghetti models defined solely on the basis of the HV and l
Tra ecdotica e comparatistica: le riviste e la fondazione della filologia romanza : atti del Convegno annuale della Scuola di dottorato europea in filologia romanza, Siena, 3-4 ottobre 2006
No full textIl volume pubblica gli atti del Convegno Annuale della Scuola di dottorato Europea in Filologia romanza tenutosi a Siena, 3-4 ottobre 2006.
Indice: M. L. Meneghetti, Presentazione. PARTE PRIMA: SAGGI. M. Zink, «Romania»: la naissance de la philologie romane en France - R. Antonelli, Dalla «Rivista di Filologia romanza» agli «Studj romanzi»: la tradizione italiana - G. Lucchini, Ascoli e l'«Archivio glottologico italiano» - G. Holtus, Gli indirizzi e l'attività principale della «Zeitschrift für romanische Philologie» nei suoi primi decenni - L. Formisano, Le riviste degli anni '70-'90 del XIX secolo e il dibattito sull'epica romanza - M. Arbor Aldea - P. L. Gradín, La dimensión europea de la lírica gallego-portuguesa en los inicios de la Filología Románica - A. Varvaro, La linguistica nelle riviste di Filologia Romanza tra 1870 e 1880. PARTE SECONDA: DOCUMENTI. S. Morgana, Il Proemio all'«Archivio Glottologico Italiano» - Prospectus di "Romania" - Prospect della «Zeitschrift für romanische Philologie» - Dall'epistolario Monaci-De Lollis. Indici.The volume contains Proceedings of the Annual Conference of the Scuola di dottorato Europea in Filologia romanza (Siena, 3-4 October 2006).
Index: M. L. Meneghetti, Presentazione. PARTE PRIMA: SAGGI. M. Zink, «Romania»: la naissance de la philologie romane en France - R. Antonelli, Dalla «Rivista di Filologia romanza» agli «Studj romanzi»: la tradizione italiana - G. Lucchini, Ascoli e l'«Archivio glottologico italiano» - G. Holtus, Gli indirizzi e l'attività principale della «Zeitschrift für romanische Philologie» nei suoi primi decenni - L. Formisano, Le riviste degli anni '70-'90 del XIX secolo e il dibattito sull'epica romanza - M. Arbor Aldea - P. L. Gradín, La dimensión europea de la lírica gallego-portuguesa en los inicios de la Filología Románica - A. Varvaro, La linguistica nelle riviste di Filologia Romanza tra 1870 e 1880. PARTE SECONDA: DOCUMENTI. S. Morgana, Il Proemio all'«Archivio Glottologico Italiano» - Prospectus di "Romania" - Prospect della «Zeitschrift für romanische Philologie» - Dall'epistolario Monaci-De Lollis. Indici
Dante conteso
No full textIndice del volume: Presentazione di Maria Luisa Meneghetti - Maria Luisa Meneghetti, La vexata quaestio della paternità del Fiore: una suggestione francese per la mise en page del suo testimone manoscritto? - Sandro Bertelli, Il frammento Laurenziano del Detto d’Amore (ms. Ashburnham 1234bis) - Adriana De Tullio, Riccardo Viel, Sulla traccia del Fiore: stratigrafie linguistiche ed ecdotiche - Luca Azzetta, Filologia ed esegesi intorno all’Epistola a Cangrande - Sabina Marinetti, Appunti sulla contesa delle egloghe, con una nota sulle intitolazioni nello Zibaldone Laurenziano - H. Wayne Storey, La questione della lettera di frate Ilar
Realtà, realismo, straniamento : Auerbach e il romanzo cavalleresco fino a Cervantes
No full textAuerbach’s research, besides exploring the three main fields the author explicitly names (i.e. the succession of different and differently grounded forms of realism in literary fiction, the alternate splitting and melting of styles, the link between literary work and a Christian vision of the world), in various chapters of Mimesis, and particularly in chs. 2, 6, 12, 14 and 20, is also focused, albeit only implicitly, on the developments of a further distinctive feature in Western literature, which is the emergence of subjectivity in the representation of reality. Focusing mainly on the chapter on courtly romance (ch. 6) and on the Quijote (ch. 14), this essay will examine Auerbach’s interpreting work on texts that adopt, in different ways, a ‘subjective point of view’; this kind of interpretation is, in part, unexpectedly similar to the approach of other critics and theorists of literature contemporary to Auerbach, like Bachtin, Américo Castro and Viktor Šklovskij
Benzothiadiazole derivatives endowed with STAT3 inhibition
No full textBENZOTHIADIAZOLE DERIVATIVES ENDOWED WITH STAT3
INHIBITION
Arianna Gelain (1), Matteo Mori (1), Ettore Gilardoni (1), Luca Regazzoni (1), Alessandro Pedretti (1),
Diego Colombo (2), Gary Parkinson (3), Akira Asai (4), Fiorella Meneghetti (1), Stefania Villa (1)
1) Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milan, Italy
2) Department of Medical Biotechnology and Translational Medicine, University of Milan, via C. Saldini 50, 20133 Milan,
Italy
3) Department of Pharmaceutical and Biological Chemistry – UCL School of Pharmacy, University College London, 29/39
Brunswick Square, WC1N 1AX London, United Kingdom
4) Center for Drug Discovery – Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku,
422-8526 Shizuoka, Japan
Signal Transducer and Activator of Transcription 3 (STAT3) is a latent cytoplasmic protein over-expressed in
various cancer cell lines1,2. As a part of our ongoing research focused on compounds showing STAT3 SH2
domain inhibiting activity3,4, by a virtual screening approach, we identified 5,6-dimethyl-1H,3H
-2,1,3-benzothiadiazole-2,2-dioxide (1) as potential inhibitor. Several derivatives were synthesized (Figure 1)
and tested. Since compound 1 exhibited the most interesting activity (IC50 = 15.8 ± 0.6 μM by
AlphaScreen-based assay), we decided to investigate the mechanism of its activity by liquid chromatography,
MS and UV studies, discovering compound 1 unexpected interaction also with cysteine residues5.
Figure 1 . Benzothiadiazole-2,2-dioxide derivatives set
References
1) Darnell, J. Jr Science, 1997, 277, 1630-1635
2) Turkson, J. and Jove R. Oncogene, 2000, 19, 6613-6626
3) Meneghetti, F.; Villa, S.; Masciocchi, D.; Barlocco, D.; Toma, L.; Han, D.C.; Kwon, B.M.; Ogo, N.; Asai, A.; Legnani, L.;
Gelain, A. European J. Org. Chem. 2015, 2015, 4907–4912
4) Porta, F.; Facchetti, G.; Ferri, N.; Gelain, A.; Meneghetti, F.; Villa, S.; Barlocco, D.; Masciocchi, D.; Asai, A.; Miyoshi,
N.; Marchianò, S.; Kwon, B.M.; Jin, Y.; Gandin, V.; Marzano, C.; Rimoldi, Eur. J. Med. Chem. 2017, 131, 196–206
5) Mori, M.; Gilardoni, E.; Regazzoni, L.; Pedretti, A.; Colombo, D.; Parkinson, G.; Asai, A,; Meneghetti, F.; Villa, S.;
Gelain, A., Molecules 2020, 25(15), 3509
Funerale di Egidio Meneghetti. Marzo 1961
No full textRaccolta di 6 fotografie del funerale di Egidio Meneghetti, fondatore con Marchesi, Saggin e Trentin del primo Comitato di Liberazione Nazionale Regionale Veneto (C.L.N.R.V.) l\u278 settembre del 1943, medaglia d\u27argento al Valor militare. Morto a Padova il 14 marzo 1961.Raccolta di 6 fotografie del funerale di Egidio Meneghetti, fondatore con Marchesi, Saggin e Trentin del primo Comitato di Liberazione Nazionale Regionale Veneto (C.L.N.R.V.) l\u278 settembre del 1943, medaglia d\u27argento al Valor militare. Morto a Padova il 14 marzo 1961
Correction to: The use of Versius CMR for pelvic surgery: a multicentric analysis of surgical setup and early outcomes (World Journal of Urology, (2024), 42, 1, (31), 10.1007/s00345-023-04730-3)
No full textIn this article, the author name Iacopo Meneghetti was incorrectly published as Jacopo Meneghetti. Now, the original article has been corrected
High-cycle fatigue crack paths in specimens having different stress concentration features
No full textThis paper summarises an attempt to study the high-cycle fatigue cracking behaviour in specimens of low carbon steel
weakened by U-notches. The specimens were tested under uniaxial fatigue loading with a load ratio equal to 0.1, and the
considered Kt values, calculated with respect to the gross area, ranged from 3.8 up to about 25. The generated crack paths
were quite irregular showing a propagation occurring in alternate trans- and intra-crystalline mode: in many cases, this
made difficult to unambiguously measure orientation and length of Stage 1 planes. In spite of these experimental difficulties,
the observed material cracking behaviour seemed to suggest that a Stage 1-like process could always be assumed to be
representative of the crack initiation phenomenon, and this held true independently of the notch sharpness. In light of the
fact that, at a mesoscopic level, crack initiations never occurred on material planes parallel to the notch bisector, we
attempted to investigate whether it was possible to use a critical plane approach to estimate high-cycle fatigue damage
in notched components under uniaxial fatigue loading. In more detail, the generated results have initially been re-analysed
by using the Modified Wo ̈ hler Curve Method re-interpreted in terms of the Theory of Critical Distances [Susmel L. A unifying
approach to estimate the high-cycle fatigue strength of notched components subjected to both uniaxial and multiaxial
cyclic loadings. Fatigue Fract Eng Mater Struct 2004;27:391–411]. The accuracy in predicting the high-cycle fatigue behaviour
of the considered multiaxial fatigue method was then compared to the accuracy of two other uniaxial approaches: the
classical one by Smith and Miller [Smith RA, Miller KJ. Prediction of fatigue regimes in notched components. Int J Mech
Sci 1978;20:201–206] and the one recently proposed by Atzori and co-workers [Atzori B, Lazzarin P, Meneghetti G. A
unified treatment of the mode I fatigue limit of components containing notches or defects. Int J Fract 2005;133:61–87]
and based on the use of some classic LEFM concepts. In particular, this comparison was performed considering virtual
specimens having the same geometries as the ones investigated in the present study, but assuming that they were made
of materials having mechanical properties known from the literature. This exercise allowed us to see that the high-cycle
fatigue damage in notched specimens under uniaxial fatigue loading can satisfactorily be predicted not only using Mode
I-crack based methods, but also using multiaxial fatigue criteria modelling the crack initiation phenomenon
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