1,721,088 research outputs found
Transformation of canine lymphoma/leukemia to more aggressive diseases : anecdotes or reality?
Full text linkTransformation is the evolution of an indolent lymphoma/leukemia to an aggressive
lymphoma, typically harboring a very poor prognosis. This phenomenon is well described
in humans, but underestimated in dogs although recognized as a possible evolution
of indolent lymphomas/leukemias. In canine chronic leukemias, blast crisis (mainly in
myeloid) and Richter syndrome (transformation into a high grade lymphoma) (mainly in
B-cell lymphocytic leukemia) have been reported. Transformation is a possible event
also in canine low grade lymphomas, although rare. The increased knowledge has also
generated new questions and posed challenges that need to be addressed to improve
outcome, including the recognition of the clinical characteristics at diagnosis associated
with a higher risk of transformation in an attempt of anticipating the typical evolution
Canine medium macronucleated cell/ marginal zone lymphoma: description of 16 cases (2001-2008).
No full textFlow Cytometric Evaluation Of Morphological Features And Antigenic Pattern In Canine Lymphoma
No full textAdjuvant gemcitabine after surgical removal of aggressive malignant mammary tumors in dogs
No full text
Canine macronucleated cell/marginal zone lymphoma : description of 16 cases (2001-2008)
No full textCanine medium macronucleated cell/marginal lymphomas (MZL) are indolent lymphomas arising from the marginal zone of B-cell follicles. The aim of this retrospective study is to gain informations about clinical features, treatments’ options and outcome of dogs with MZL.
Materials and Methods: 16 dogs with a cytological/ histopathological diagnosis of MZL. Clinical, laboratory and follow-up data were collected.
Results. The splenic form predominated (50.0%, 8 cases), followed by nodal (31.2%, 5 cases) and disseminated (18.8%, 3 cases) subtypes. The great majority of dogs had stage IV disease (62.5%). Among splenic MZL, 4 dogs underwent splenectomy and adjuvant chemotherapy, 3 dogs were treated by means of chemotherapy, and 1 dog underwent surgery only. The 3 longest survivals were recorded in dogs with splenic MZL treated by means of surgery and adjuvant chemotherapy. All dogs with nodal MZL were treated with systemic chemotherapy; 4 (80.0%) achieved complete remission and 1 partial remission. Two out of the 3 dogs with disseminated MZL had the shortest survival. During the disease course, 2 (12.5%) dogs transformed into high-grade centroblastic lymphoma. Median survival for all dogs was 549 days.
Conclusions and clinical importance. Anatomic origin of MZL may delineate tumors with distinct biological behavior in dogs. Splenic MZL appears indolent and may benefit from splenectomy, possibly followed by systemic chemotherapy. Nodal and disseminated MZL seems to be clinically aggressive, possibly requiring dose-intense chemotherapeutic strategies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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