573 research outputs found
A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen
No full textAIMS OF THE STUDY: Maca (Lepidium meyenii Walp) is consumed both as a sports supplement by strength and endurance athletes, and as a natural stimulant to enhance sexual drive. However, whether or not the postulated benefits of maca consumption are of scientific merit is not yet known. The aim of the study was therefore to investigate the effect of 14 days maca supplementation on endurance performance and sexual desire in trained male cyclists.
MATERIALS AND METHODS: Eight participants each completed a 40 km cycling time trial before and after 14 days supplementation with both maca extract (ME) and placebo, in a randomised cross-over design. Subjects also completed a sexual desire inventory during each visit. RESULTS: ME administration significantly improved 40 km cycling time performance compared to the baseline test (P=0.01), but not compared to the placebo trial after supplementation (P>0.05). ME administration significantly improved the self-rated sexual desire score compared to the baseline test (P=0.01), and compared to the placebo trial after supplementation (P=0.03).
CONCLUSIONS: 14 days ME supplementation improved 40 km cycling time trial performance and sexual desire in trained male cyclists. These promising results encourage long-term clinical studies involving more volunteers, to further evaluate the efficacy of ME in athletes and normal individuals and also to explore its possible mechanisms of action
Lepidium meyenii (Maca) in male reproduction
No full textLepidium meyenii (Maca) is an edible root plant that grows in the Andean region of Peru. For centuries, the plant has been used as a dietary supplement for its nutritional and therapeutic properties. Maca are rich in high value nutritional elements and secondary metabolites (macaridine, macamides and glucosinolates) with high biological activity. Several studies demonstrated various biological effects of Maca mainly in the field of fertility. The aim of this review is to summarize the state of knowledge on the properties of Maca on male reproduction. Literature data was performed in PubMed with researches published from 2000 to 2019. The research showed results related to the effects of Maca on the quality and quantity of the semen, sexual behaviour and disorders of the male genital tract. Despite the numerous studies carried out on different animal species, further research is needed to clarify the mechanisms of action of Maca
Custo de Producao de Maca.
No full textO presente estudo procura responder as indagacoes existentes no que diz respeito ao custo de producao da cultura da macieira. Com base em dados coletados na regiao do Alto Vale do Rio do Peixe, SC, determinou-se que o custo do kg de maca produzido em pomar de bom nivel tecnologico gira em torno de 0,02 OTN (precos de novembro de 1987), podendo-se enquadrar a maca como um dos produtos de mais alto custo de producao no Estado
Maca: its uses in menopause
No full textThe Lepidium meyenii plant also known as Peruvian Maca originates from high altitudes in the Andes, and it has a high nutritional content and is extensively used as an herbal supplement for conditions such as sexual dysfunction, semen quality, and menopausal symptoms. This narrative review was conducted to assess the effects of Maca on a variety of conditions but doing emphasis on menopausal symptoms. Studies published in the English and Spanish languages were included in the review. Following the PRISMA guidelines, we identified published studies through an electronic review of the literature searches of PubMed, Medline, ISI, DOAJ, Springer, and Embase. Web of Knowledge, DOAJ, and Google Scholar for original articles written in the English language, and Scielo, Lantidex, Imbiomed-L, Redalyc, and Google Scholar for original articles written in the Spanish language. After reviewing the literature, the information available does not provide enough evidence about the effectiveness of Maca in improving menopausal symptoms
Custo de Producao de Maca.
No full textO presente estudo procura responder as indagacoes existentes no que diz respeito ao custo de producao da cultura da macieira. Com base em dados coletados na regiao do Alto Vale do Rio do Peixe, SC, determinou-se que o custo do kg de maca produzido em pomar de bom nivel tecnologico gira em torno de 0,02 OTN (precos de novembro de 1987), podendo-se enquadrar a maca como um dos produtos de mais alto custo de producao no Estado.Made available in DSpace on 2011-04-09T12:16:05Z (GMT). No. of bitstreams: 1
pab08maio92.pdf: 237437 bytes, checksum: 6a8bc27cf9df0ddfd98bb47c030b812a (MD5)
Previous issue date: 2001-08-2
Subjective effects of Lepidium Meyenii (Maca) extract on wellbeing and sexual performances in patients with mild erectile dysfunction: a randomized, double-blind clinical trial.
No full textLepidium meyenii (Maca) is a cultivated root belonging to the brassica family used in the Andean region for its supposed aphrodisiac properties. We carried out a double-blind clinical trial on 50 Caucasian men affected by mild erectile dysfunction (ED), randomised to treatment with Maca dry extract, 2400 mg, or placebo. The treatment effect on ED and subjective well-being was tested administrating before and after 12 weeks the International Index of Erectile Function (IIEF-5) and the Satisfaction Profile (SAT-P). After 12 weeks of treatment, both Maca- and placebo-treated patients experienced a significant increase in IIEF-5 score (P < 0.05 for both). However, patients taking Maca experienced a more significant increase than those taking placebo (1.6 +/- 1.1 versus 0.5 +/- 0.6, P < 0.001). Both Maca- and placebo-treated subjects experienced a significant improvement in psychological performance-related SAT-P score, but the Maca group higher than that of placebo group (+9 +/- 6 versus +6 +/- 5, P < 0.05). However, only Maca-treated patients experienced a significant improvement in physical and social performance-related SAT-P score compared with the baseline (+7 +/- 6 and +7 +/- 6, both P < 0.05). In conclusion, our data support a small but significant effect of Maca supplementation on subjective perception of general and sexual well-being in adult patients with mild ED
Maca (L. meyenii) for erectile dysfunction: a systematic review and meta-analysis
No full textMaca (Lepidium meyenii) has been reported to improve
erectile function (EF). The purpose of this study was to evaluate the clinical
evidence for or against maca as a therapy for erectile dysfunction (ED) in men.
We searched 11 databases for randomized controlled trials (RCTs)
comparing any type of maca with a placebo in the treatment of ED in men. The
primary endpoint was EF, while the secondary endpoints were quality of life and
adverse events. Risk of bias (ROB) was assessed using the Cochrane ROB tool 2.0.
Study selection, data extraction, and assessment were independently performed by
two researchers. RevMan 5.4.1 software (Cochrane Collaboration, 2020) was used
for data aggregation, and the Grades of Recommendation, Assessment, Development
and Evaluation (GRADE) assessment was used to evaluate the quality of the study
outcomes. Only two RCTs met all the inclusion criteria. These RCTs
examined the effects of maca on EF in patients with mild ED. One RCT showed a
positive effect of maca on EF, whereas the other RCT did not. The results of the
meta-analysis indicate that maca has positive effects on EF in men with mild ED
(n = 79, MDs 1.13: 0.64 to 1.61, p = 0.01; p < 0.0001).
Our comprehensive review found limited evidence for the benefits of
maca in improving EF. Several limitations, including the total number of studies
and their sample sizes, were insufficient to draw firm conclusions. Further
studies are needed
Maca (<it>L. meyenii</it>) for improving sexual function: a systematic review
No full textAbstract Background Maca (Lepidium meyenii) is an Andean plant of the brassica (mustard) family. Preparations from maca root have been reported to improve sexual function. The aim of this review was to assess the clinical evidence for or against the effectiveness of the maca plant as a treatment for sexual dysfunction. Methods We searched 17 databases from their inception to April 2010 and included all randomised clinical trials (RCTs) of any type of maca compared to a placebo for the treatment of healthy people or human patients with sexual dysfunction. The risk of bias for each study was assessed using Cochrane criteria, and statistical pooling of data was performed where possible. The selection of studies, data extraction, and validations were performed independently by two authors. Discrepancies were resolved through discussion by the two authors. Results Four RCTs met all the inclusion criteria. Two RCTs suggested a significant positive effect of maca on sexual dysfunction or sexual desire in healthy menopausal women or healthy adult men, respectively, while the other RCT failed to show any effects in healthy cyclists. The further RCT assessed the effects of maca in patients with erectile dysfunction using the International Index of Erectile Dysfunction-5 and showed significant effects. Conclusion The results of our systematic review provide limited evidence for the effectiveness of maca in improving sexual function. However, the total number of trials, the total sample size, and the average methodological quality of the primary studies were too limited to draw firm conclusions. More rigorous studies are warranted.</p
Maca (Lepidium meyenii Walp.) inhibits HIV-1 infection through the activity of thiadiazole alkaloids in viral integration
No full text"Ethnopharmacology relevance: Lepidium meyenii Walp. (maca) has been traditionally used for centuries in the Central Andes region both as food and as medicine. In the last decades, its fertility enhancer properties have gained importance, with the majority of the scientific literature related to this topic. However, other traditional uses are less known as metabolic or infectious diseases.
Aim of the study: The main purpose of this study is to investigate the anti-infectious activity of L. meyenii, spe- cifically in HIV-1 infection. There are previous reports of the transcriptional related activity of L. meyenii extracts in human T lymphocytes via transcription factors as NF-κB. Since T lymphocytes are the main target of HIV-1 infection and NF-κB is strongly involved in HIV-1 transcription, L. meyenii could display antiviral activity.
Material and methods: Chromatography and spectroscopy techniques were used to isolate and identify the compounds in the active extracts. An antiviral assay system based on recombinant viruses was used to evaluate the anti-HIV activity. Cell toxicity was tested for all the extracts and compounds. Viral entry was studied using VSV-HIV chimera viruses and reverse transcription and viral integration were studied by qPCR of viral DNA in infected cells. Finally, viral transcription was studied in primary lymphocytes transfected with HIV-1 or NF-κB luciferase reporter plasmids.
Results: n-Hexane extracts of purple maca displayed anti-HIV activity in an in vitro assay. A bioassay-guided fractionation led to the identification of three thiadiazole alkaloids with antiviral activity. All the compounds were able to inhibit HIV infection of MT-2 cell lines and primary lymphocytes (PBMCs) with IC50 values in the low micromolar range. The mechanism of action differs between the three compounds: one of them showed activity on viral entry, and all the three compounds inhibited viral integration at low concentrations. Remark- ably, none of the compounds inhibited reverse transcription or viral transcription.
inhibit HIV-1 infection in vitro and three active thiadiazole alkaloids were isolated acting mainly on viral integration and viral entry."Instituto de Salud Carlos III, Biomedical Research Networking Centre Infectious DiseasesEuropean Regional Development FundDepto. de Farmacología, Farmacognosia y BotánicaFac. de FarmaciaTRUEpu
Maisto papildo Maca booster poveikis sportininkų organizmo adaptacijai prie fizinių krūvių
No full textSportininkai vis labiau vartoja Vokietijos fi rmoje „Almondi“ gaminamą maisto papildą Maca booster. Pagrindinis šio maisto papildo komponentas yra natūralus augalas peruvinė pipirinė (Lepidium meyenii) (Maca), auganti Andų kalnuose (4000—4500 m virš jūros lygio). Nors šis augalas vartojamas kaip tonizuojamoji medžiaga, mažinanti nuo-vargį, didinanti potenciją ir vaisingumą, gerinanti medžiagų apykaitą, normalizuojanti vegetacinės nervų sistemos funkciją, gerinanti organizmo imuninę būklę, stiprinanti širdies ir kraujagyslių sistemą, didinanti ištvermę esant de-guonies trūkumui ir pan., tačiau moksliniais tyrimais tai dar nepakankamai įrodyta. Taigi tyrimo tikslas — nustatyti, kaip maisto papildas Maca booster veikia sportininkų fi zinį darbingumą, morfologinę ir biocheminę kraujo sudėtį. Buvo tiriama 16 sportininkų, kurių amžius — 20—22 metai. Tiriamieji 20 dienų vartojo po 5 maisto papildo Maca booster kapsules per dieną: po 2 kapsules ryte, 1 — per pietus ir 2 —vakare. Vienoje kapsulėje yra 800 mg sausų peruvinės pipirinės šaknų miltelių. Sportininkai buvo tiriami prieš pradedant jiems vartoti maisto papildą, praėjus 10 ir 20 dienų nuo vartojimo pradžios ir praėjus 20 dienų po šio papildo vartojimo pabaigos. Nustatytas vienkartinis raumenų susitraukimo galingumas (VRSG), anaerobinis alaktatinis raumenų galingumas (AARG), raumenų galingumas atliekant 10 s trukmės krūvį maksimaliomis pastangomis, anaerobinis glikolitinis pajėgumas (AGP). Aerobiniam pajėgumui vertinti taikėme PWC 170 testą. Kraują morfologiniams, biocheminiams ir hormonų tyrimams atlikti ėmėme iš venos. Per eksperimentinį laikotarpį santykinis VRSG padidėjo nuo 25,9 iki 27,4 W / kg (p < 0,05). Santykinis AARG rodiklis per tiriamąjį laikotarpį padidėjo nuo 16,3 ± 0,3 iki 17,3 ± 0,4 W / kg (p < 0,05). 10 s trukmės krūvio maksimaliomis pastangomis darbo galingumo reikšmė didėjo nuo 18,3 ± 0,5 iki 20,3 ± 0,5 W / kg (p < 0,05). Anaerobinis glikoli-tinis pajėgumas (AGP) didėjo nuo 494,8 ± 12,3 W iki 530,1 ± 11,0 W (p < 0,05) o santykinis — nuo 6,4 ± 0,1 iki 6,8 ± 0,1 W / kg (p < 0,05). Laktato koncentracija kraujyje padidėjo nuo 13,6 ± 0,5 iki 15,5 ± 0,6 mmol / l (p < 0,01). Nustatėme, kad 20 dienų vartojant maisto papildą Maca booster PWC 170 padidėjo vidutiniškai 8,8 W (p > 0,05). Nekintant leukocitų kiekiui sportininkų kraujyje, po 10 dienų Maca booster vartojimo padidėjo limfocitų procentas nuo 34,8 iki 39,9% ir skaičius — nuo 2,4 ± 0,2 iki 2,5 ± 0,16 10 9 / l (p < 0,05). Tiriamųjų kraujyje kreatinkinazės, kreatinino, šlapimo rūgšties ir šlapalo koncentracijos poslinkiai per eksperimentinį laikotarpį parodė, kad Maca booster vartojimas gali lemti sportininkų organizmo fi zinių galių didėjimo galimybes. Vartojant Maca booster, jau po 10 dienų buvo pastebėtas testosterono koncentracijos padidėjimas nuo 28,6 ± 1,94 iki 31,95 ± 2,15 μmol / l (p > 0,05). Po 20 dienų šio papildo vartojimo testosterono kiekis statistiškai reikšmingai sumažėjo iki 26,06 ± 1,60 μmol / l.Taigi tyrimas parodė, kad maisto papildas Maca booster teigiamai veikia sportininkų fi zinį pajėgumą įvairiose ener-gijos gamybos zonose ir jų organizmo imuninę būseną.Raktažodžiai: maisto papildai, fizinis išsivystymas, fizinis galingumas, funkcinis pajėgumas
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