1,721,055 research outputs found
Recent Trends in Antitumor Gold(III) Complexes: innovative cytotoxic metallodrugs for cancer treatment
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The interaction of the antitumor complexes Na[trans-RuCl4(DMSO)(Im)] and Na[trans-RuCl4(DMSO)(Ind)] with apotransferrin: a spectroscopic study
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Interplay of crystallography, Raman microspectroscopy and electrospray mass spectrometry for studying the reaction between ruthenium complexes and proteins
No full textRuthenium complexes are evaluated as prospective pharmaceutical agents and have emerged as promising alternatives to Platinum compounds for anticancer chemotherapy. Due to the large interest of this class of compounds for bioinorganic chemistry and biomedical applications, it is demanding to investigate their reactivity with proteins. The reaction between NAMI-A and AziRu, two structurally related Ru(III) compounds with antitumor activity, and the model proteins hen egg white lysozyme, HEWL, and bovine pancreatic ribonuclease, RNase A, was investigated through electrospray ionization mass spectrometry, Raman microscopy, UV-visible absorption spectroscopy and X-ray crystallography [1-3]. In all cases, formation of stable metal-protein adducts was unambiguously demonstrated. Similarly, the product of the reaction between the paddle-wheel tetrakis(acetato)chlorido diruthenium(II,III) complex, [Ru2(μ-O2CCH3)4Cl], and HEWL has been characterized [4]. Taken together, the results of these works suggest that the combined used of X-ray crystallography, Raman microspectroscopy and electrospray mass spectrometry is a valuable tool for examining in detail the protein metalation process.
[1] A. Vergara, G. D’Errico, D. Montesarchio, G. Mangiapia, L. Paduano, A. Merlino. Inorg Chem. 2013, 52(8):4157-9. [2] A. Vergara, D. Montesarchio, I. Russo Krauss, L. Paduano, A. Merlino. Inorg Chem 2013, 52(19):10714-10716. [3] L. Messori, A. Merlino. Dalton Trans 2014, 43, 6128-31.[4] L. Messori, T. Marzo, R. N. Fernandes Sanches, H.-U.-Rehman, D. de Oliveira Silva, A. Merlino. Angewandte Chemie Int. Ed. 2014, DOI: 10.1002/anie.201403337 and 10.1002/ange.20140333
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Evidence of a metal-synergistic anion bond in Thallium(III) transferrin
No full textThe 205Tl and 13C NMR spectra of Tl(III)-substituted transferrin have been recorded. Insight has been gained into the metal binding mode of the synerbistic anion carbonate
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