492 research outputs found
Renal Cancer
No full textRenal cell carcinoma (RCC) is a tumor where new biological knowledge has changed the landscape: indeed, antiangiogenic agents and immunotherapy are changing the natural history of disease. New discoveries in targeted therapy are paralleled by those in immunotherapy: the treatment paradigm continues to evolve.
The currently available drugs do not benefit every patient equally. Biological factors particular to certain individuals have a clear effect on this variation in response.
Given the increasing number of treatment options but without the same benefit for every patient, the patient selection in the future will be the key. Predictive biomarkers are required for treatment personalization.
Multidisciplinarity is important also for the emerging role of cytoreductive nephrectomy and metastasectomy in selected cases.
The future is represented by new drugs, new combinations, and the development of precision therapy
The economic advantage of allergen immunotherapy over drug treatment in respiratory allergy
No full textTRATTAMENTO DELLA CHERATITE ERPETICA SPERIMENTALE CON ANTICORPI POLICLONALI E MONOCLONALI
No full textL'ARTICOLO DESCRIVE I RISULTATI DEL TRATTAMENTO DELLA CHERATITE ERPETICA SPERIMENTALE CON ANTICORPI POLICLONALI E MONOCLONALI NEL MODELLO ANIMALE
EMORRAGIE MACULARI SPONTANEE NELLA MIOPIA
No full textIL LAVORO DESCRIVE ALCUNI CASI CLINICI AFFETTI DA EMORRAGIE MACULARI SPONTANEE DI ORIGINE COROIDEALE E NON LEGATE A FENOMENI DI NEOVASCOLARIZZAZIONE SOTTORETINICA IN PAZIENTI CON MIOPIA DEGENERATIVA
The molecular tumor board: a tool for the governance of precision oncology in the real world
No full textClinical oncology is going through a period of profound change. Targeted therapy, and more recently immunotherapy, have revolutionized the natural history and outcomes of many solid tumors. Clinical oncology is now indissoluble from molecular oncology, a rapidly evolving field. This profound transformation is the rationale for molecular tumor board (MTB) implementation. MTBs represent a resource for the development of precision oncology and clinical practice implementation is a complex and important challenge for the future of clinical and molecular oncology. Economic sustainability of genomic tests, access to drugs or clinical trials according to the MTB recommendation, and expanded use of existing anticancer drugs are required for MTBs to become a useful tool for the governance of precision oncology in the real world. This is an ongoing process, with establishment of MTBs the first step. Continuing to work in collaboration with scientific societies, MTBs are poised to become a homogeneous and well-structured reality that can make the care pathway of the patient with cancer more efficient, with the ultimate goal to offer personalized therapy based on the most advanced scientific knowledge
Functional anatomy of the Eustachian tube.
No full textThe Eustachian tube (ET) is divided in 3 portions: a bony portion, a cartilaginous portion, and a junctional portion. From an anatomical-functional point of view, the bony portion of ET is the region of ventilation and clearance of secretions, and is lined by pseudostratified, ciliated, columnar epithelium, with an anti-gravitational direction of the drainage. The ET in the bony portion is in a state of forced opening. The cartilaginous portion is instead the heart of this dynamic system tube, because the mechanism of opening and closing of the tube is at this level. ET is normally closed, and it opens only during swallowing, being essential for good functioning of the middle ear, because it provides ventilation from the nasopharynx to the middle ear, and, at the same time, clearance of secretions from the middle ear-mastoid unit to the nasopharynx. Moreover, the ET protects the middle ear against nasopharyngeal pressure variations, ascending secretions, and microorganisms. The ability to develop all these functions makes the tube a complex organ
RETINOPATIA DIABETICA NELLA TALASSEMIA: STUDIO LONGITUDINALE IN PAZIENTI AFFETTI DA BETA-TALASSEMIA MAIOR E DIABETE SECONDARIO INSULINO-DIPENDENTE
No full textL'ARTICOLO DESCRIVE LE CARATTERISTICHE CLINICHE ED EPIDEMIOLOGICHE DELLA RETINOPATIA DIABETICA IN PAZIENTI AFFETTI DA BETA-TALASSEMIA MAIOR E DIABETE SECONDARIO INSULINO-DIPENDENT
Functional anatomy of the Eustachian tube
No full textThe Eustachian tube (ET) is divided in 3 portions: a bony portion, a cartilaginous portion, and a junctional portion. From an anatomical-functional point of view, the bony portion of ET is the region of ventilation and clearance of secretions, and is lined by pseudostratified, ciliated, columnar epithelium, with an anti-gravitational direction of the drainage. The ET in the bony portion is in a state of forced opening. The cartilaginous portion is instead the heart of this dynamic system tube, because the mechanism of opening and closing of the tube is at this level. ET is normally closed, and it opens only during swallowing, being essential for good functioning of the middle ear, because it provides ventilation from the nasopharynx to the middle ear, and, at the same time, clearance of secretions from the middle ear-mastoid unit to the nasopharynx. Moreover, the ET protects the middle ear against nasopharyngeal pressure variations, ascending secretions, and microorganisms. The ability to develop all these functions makes the tube a complex organ
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