25,317 research outputs found
Exploration of radiotherapy-related insufficiency fractures and risk factors of patients diagnosed with gynaecological cancer treated with radiotherapy: a service evaluation
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Hands-off and hands-on casting consistency of amputee below knee sockets using magnetic resonance imaging
No full textResidual limb shape capturing (Casting) consistency has a great influence on the quality of socket fit. Magnetic Resonance Imaging was used to establish a reliable reference grid for inter cast and intra cast shape and volume consistency of two common casting methods, Hands-off and Hands-on. Design: Residual limbs were cast for twelve people with a unilateral below knee amputation and scanned twice for each casting concept. Subsequently, all four volume images of each amputee were semi-automatically segmented and registered to a common coordinate system using the tibia and then the shape and volume differences were calculated. Results: The results show that both casting methods have intra cast volume consistency and there is no significant volume difference between the two methods. Inter and intra cast mean volume differences were not clinically significant based on the volume of one sock criteria. Neither the Hands-off nor the Hands-on method resulted in a consistent residual limb shape as the coefficient of variation of shape differences was high. Conclusion: The resultant shape of the residual limb in the Hands-off casting was variable but the differences were not clinically significant. For the Hands-on casting, shape differences were equal to the maximum acceptable limit for a poor socket fit
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Hands-Off Options
No full textExecutives' use of inside information and price manipulation to boost their trading profits hurts public investors. Each extra dollar pocketed by managers comes at the expense of public shareholders. This Article suggests that firms use what the author calls "hands-off" options-options that are cashed out according to a fixed, gradual, and pre-announced schedule. By removing executives' control over the timing of unwinding, such options would make it impossible for executives to sell on inside information. Because this hands-off approach would reduce executives' ability to boost their pay under shareholders' radar screens, managers are likely to resist its adoption. Boards, in turn, may be reluctant to insist on a hands-off arrangement in the face of managers' objections. Thus, institutional investors -- who in the past have had some success in improving executive pay arrangements -- should strongly encourage firms to adopt the hands-off approach.Version of Recor
The laying on of hands in the New Testament.
No full textThis study investigates the procedural techniques, significance and the tangible effects of the laying on of hands in the New Testament. The introductory chapter reviews critically previous contributions to the subject of the laying on of hands in the New Testament and establishes the purpose and delimitations of this study and the methodology used. The next two chapters are devoted to a study of the background of the New Testament practice of the laying on of hands. The investigation is conducted in the Old Testament and contemporary Judaism (Chapter Two) and in the Graeco-Roman and Near-Eastern literature (Chapter Three). Chapters Four through Seven are exegetical, each discussing a particular use of the laying on of hands in the New Testament. Chapter Four examines the function of the gesture in healing. Special attention is given to the inner process of transfer of power through physical contact. A comparative study of Jesus' method of healing with similar practices of his contemporaries challenges the idea that the origin of the healing touch is Hellenistic. The custom of blessing with the laying on of hands, as practised by Jesus, is examined in Chapter Five in terms of origin, significance and the form of the gesture. The next chapter is devoted to the use of the laying on of hands for the reception of the Holy Spirit. In addition to the exegetical analysis of the relevant pericopes, an attempt is made to explain the circumstances which led to the birth of this distinctive Christian practice. Chapter Seven examines the use of the laying on of hands in ordination and commissioning. It discusses the significance of the gesture, argues for the Jewish origin of the Christian rite and opposes the view that in the post-Pauline period charismata are tied to an office and thus institutionalised. In the final section of the thesis, an attempt is made to gauge the possibility of any uniformity in the significance of the various New Testament uses of the laying on of hands
Hands-on Science
No full textIn the Society of our days there is a major increasing need of an in depth quality education in Science and Technology. Science teaching at school should be generalised aiming not only the sound establishment of a “Science” culture in our societies but also to guarantee a steady basis for the improvement of Science and its technological applications. Urgent actions should be taken in this direction. By initiative of the author the “Hands-on Science” (H-Sci) network was created. The European Commission under the program Socrates, Comenius 3 action (project nº. 110157-CP-1-2003-1-PT-COMENIUS-C3) supports the network
A comparison of hands off versus hands on techniques on perineal trauma during birth in nulliparous women
No full textBackground & Objective: Perineal trauma usually occurs during childbirth and associated with short and long term complication for women. Blood loss, urinary, fecal and sexual incontinence are effects of after childbirth complications of perineal trauma. These can cause maternal and newborn morbidity. This study wanted to compare the effectiveness of two techniques for perineum protection “hand off” versus “hand on” (Ritgen) during childbirth from view points of frequency, degree and suture of perineal trauma.
Methods: This randomized clinical trial study carried out 70 nulliparus women that expecting normal birth of a singleton. They were randomly selected and divided in hands off and hands on (N = 35) groups. In the “hands on” method, midwife put pressure on the baby’s head and support (‘guard”) the perineum; then lateral flexion is used to facilitate delivery of the shoulders, and in the “ hands off” method, midwife keep her hands poised, not touching the head or perineum, allowing spontaneous delivery of the shoulders. We analyzed data with descriptive statistical methods, t-test, chi-squer, mann whitney and non parametric tests by SPSS.
Results: Rates of intact perineum was significantly higher in the “hands off” group (50%, 40%, p=0.48). The first and second degree tears were significantly lower in the “hands off” group (40.6%, 50%, vs., 9.4%, 10%, p= 0.48). We did not observe any significant differences in the rate of lacerations in the anterior regions of the perineum and frequency of suture between the two groups.
Conclusions: The hands off technique in the second stage of labour increases the likelihood of an intact perineum
Transmission of helminth eggs through hands in a high-risk community.
No full textBACKGROUND: The role that hands play in the transmission of Ascaris is not well understood. METHODS: A newly developed method to quantify the presence helminth eggs on hands was tested among a group of farmers in Vietnam. High turbidity in hand rinse samples meant that the adopted sugar solution had to be replaced by zinc sulphate as a flotation solution. RESULTS: The survey found 34% (31/90) of study participant hands' were positive for helminth eggs, though concentrations were low and ranged from 0-10 eggs/2 hands. The use of fresh excreta in agriculture was the only variable that showed an association with the concentrations of eggs found on hands. CONCLUSIONS: The results highlight the need to promote handwashing with soap to prevent the transmission of soil-transmitted helminth infections
Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington’s disease
No full textHD (Huntington's disease) is caused by a polyQ (polyglutamine) expansion in the huntingtin protein, which leads to protein misfolding and aggregation of this protein. Abnormal copper accumulation in the HD brain was first reported more than 15 years ago. Recent findings show that copper-regulatory genes are induced during HD and copper binds to an N-terminal fragment of huntingtin, supporting the involvement of abnormal copper metabolism in HD. We have demonstrated that in vitro copper accelerates the fibrillization of an N-terminal fragment of huntingtin with an expanded polyQ stretch (httExon1). As we found that copper also increases polyQ aggregation and toxicity in mammalian cells expressing httExon1, we investigated further whether overexpression of genes involved in copper metabolism, notably MTs (metallothioneins) known to bind copper, protect against httExon1 toxicity. Using a yeast model of HD, we have shown that overexpression of several genes involved in copper metabolism reduces polyQ-mediated toxicity. Overexpression of MT-3 in mammalian cells significantly reduced polyQ aggregation and toxicity. We propose that copper-binding and/or -chaperoning proteins, especially MTs, are potential therapeutic targets for HD
mTOR’s role in ageing: protein synthesis or autophagy?
No full textThe molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways
The effect of handwashing with water or soap on bacterial contamination of hands.
No full textHandwashing is thought to be effective for the prevention of transmission of diarrhoea pathogens. However it is not conclusive that handwashing with soap is more effective at reducing contamination with bacteria associated with diarrhoea than using water only. In this study 20 volunteers contaminated their hands deliberately by touching door handles and railings in public spaces. They were then allocated at random to (1) handwashing with water, (2) handwashing with non-antibacterial soap and (3) no handwashing. Each volunteer underwent this procedure 24 times, yielding 480 samples overall. Bacteria of potential faecal origin (mostly Enterococcus and Enterobacter spp.) were found after no handwashing in 44% of samples. Handwashing with water alone reduced the presence of bacteria to 23% (p < 0.001). Handwashing with plain soap and water reduced the presence of bacteria to 8% (comparison of both handwashing arms: p < 0.001). The effect did not appear to depend on the bacteria species. Handwashing with non-antibacterial soap and water is more effective for the removal of bacteria of potential faecal origin from hands than handwashing with water alone and should therefore be more useful for the prevention of transmission of diarrhoeal diseases
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