153 research outputs found
An atypical case of iatrogenic LAD dissection following PCI: Diagnostic and management challenges
No full textIatrogenic coronary artery dissection is listed among the rare complications of interventional cardiology procedures, such as diagnostic angiography and percutaneous coronary intervention (PCI), which are worldwide routine in clinical practice. Although extremely infrequent, they can lead to severe myocardial injury and even to death. In the following case, we present an iatrogenic left anterior descending coronary artery (LAD) dissection, which led to an ischemic dilated cardiopathy. This case was radiologically and clinically worthy of note for the atypical site of dissection, the lack of symptoms although the ischemic damage and the global management requiring a multidisciplinary approach
: Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4
No full textTrattato di Medicina Interna : Le Sindromi Renali.
No full textIn un'epoca di globalizzazione, il sapere medico non può far agio sulla cultura internazionale di spicco nell'avanzamento della medicina, ma nel contempo non può astrarsi dal contesto territoriale in cui avviene l'esercizio della professione medica.
In considerazione di ciò, il "Teodori 2004 - Trattato Italiano di Medicina Interna", nella sua VIIa edizione, si è arricchito di 30 nuovi capitoli ed aggiornato secondo i più recenti dettami della medicina, con Autori altamente qualificati nella materia. Inoltre ha preso in considerazione aspetti epidemiologici-clinico-terapeutici particolarmente attintenti alla realtaà della patologia internistica in Italia.
Questa simbiosi di universalità dello scibile e di aderenza alla situazione clinica del nostro territorio, costituisce un punto di froza dell'opera che accrescerà il successo editoriale che essa ha sempre avuto.
È per queste sue preorogative che ci sentiamo di proporre all'attenzione del corpo docente universitario, degli studenti delle Facoltà Mediche, dei medici professionisti, l'adozione di questo trattato come testo di acculturamento e di formazione per la laurea in Medicina e Chirurgia, nonché per l'esercizio pratico della professione medica.
Convinti della validità di questo "Trattato" quale opera innovatrice nella trattatistica medica italiana, sospinti dalle continue richieste di realizzare un'opera rinnovata, sicuri di interpretare la volontà del Prof. Ugo Teodori e desiderosi che il suo nome non venga dimenticato come testimonianza di gratitudine e di fedeltà ai suoi insegnamenti, ci siamo assunti l'impegno di affrontare la preparazione di questa nuova edizione.
La nuova opera ha richiesto grande impegno organizzativo e la piena disponibilità da parte dei Coordinatori e degli oltre 250 Collaboratori che hanno accettato anche limiti di spazio per contenere il testo in due volumi. A tutti un vivo ringraziamento.
Un particolare ringraziamento va rivolto al nostro staff redazionale per aver curato con la cunsueta professionalità e in piena collaborazione con gli Autori la realizzazione dell'opera.
È pertanto con orgoglio che presentiamo il "Teodori 2004-Trattato Italiano di Medicina Interna" che per la sua completezza, organicità, aggiornamento e riferimenti bibliografici, si colloca tra le migliori opere della letteratura scientifica internazionale.
Tra i pregi dell'opera non va, peraltro, trascurato il costo veramente interessante per il suo acquisto
Multilevel symmetrized Toeplitz structures and spectral distribution results for the related matrix sequences
No full textIn recent years, motivated by computational purposes, the singular value and spectral features of the symmetrization of Toeplitz matrices generated by a Lebesgue integrable function have been studied. Indeed, under the assumptions that f belongs to L-1 ([-pi, pi]) and it has real Fourier coefficients, the spectral and singular value distribution of the matrix-sequence {YnTn[f]}(n), has been identified, where n is the matrix size, Y-n is the anti-identity matrix, and T-n [f] is the Toeplitz matrix generated by f. In this note, the authors consider the multilevel Toeplitz matrix T-n [f] generated by f is an element of L-1 ([-pi, pi](k)), n being a multi-index identifying the matrix-size, and they prove spectral and singular value distribution results for the matrixsequence {YnTn [f]}(n) with Y-n being the corresponding tensorization of the anti-identity matrix.</p
Autosomal dominant polycystic kidney disease: from genes to cilium.
No full textAutosomal dominant polycystic kidney disease (ADPKD) is a quite frequent monogenic hereditary disease. The incidence has been reported to range between 1:400 and 1:1000 life births. The disease is caused by a mutation of the PKD1 gene in 85% of the cases and by a mutation of the PKD2 gene in the remaining 15%. The main characteristic of this condition is the development of renal cysts. Observations regarding various cystic kidney diseases sustained by mutations of different genes are steadily converging to a common point. This unifying element is the primary cilium. The cilium, which has long been considered a mere biological oddity, has lately become the focus of intense scientific attention because it may turn out to be the key to the understanding of cystic degeneration. The cilia can be regarded as sensors projecting out of the cell. In particular in the kidney they are located in an ideal place to capture information from the tubular lumen. One of the roles the cilia may play is the reception of chemical signals. An alternative hypothesis attributes to the cilia the role of mechanosensors capable of detecting variations of the urine flux in the tubular lumen. The cilium projects itself into the lumen where it can readily capture variations in the external environment and transmit them to the cell by as yet undefined pathways. This is the still largely unexplored frontier that will provide the elements needed to understand and treat renal cystic diseases
Coincident chronic inflammatory demyelinating polyneuropathy and focal segmental glomerulosclerosis: a common autoimmunity?
No full textA 40-year-old male developed swallowing difficulties, loss of strength, and imbalance. On admission, the patient exhibited bifacial, extremity weakness, ataxia, impaired sensation, and areflexia. Electrophysiology and nerve biopsy suggested demyelination. Spinal fluid revealed increased protein content. Plasmapheresis showed benefit, but neuropathy relapsed. At second recurrence, urine analysis showed heavy proteinuria. Renal biopsy revealed focal segmental glomerulosclerosis (FSGS). Methylprednisolone and oral cyclophosphamide were given. Long-term steroids and immunoglobulin showed steady benefit. Concurrence of chronic inflammatory demyelinating polyneuropathy and FSGS suggests synergistic cellular and humoral autoimmune mechanisms related to either cross-reactivity within antigenic targets or mimicry between neural and renal epitopes
Input Allocation for the Propeller-Based Overactuated Platform ROSPO
No full textWe apply input allocation to a redundantly actuated platform driven by tilting aerodynamic propulsion units: the ROtor graSPing Omnidirectional (ROSPO). This platform represents a novel testbed for redundancy allocation designs in propeller-driven platforms. The control solution is based on a hierarchical architecture, made of a high-level controller for trajectory tracking, and a nonlinear input allocation algorithm. The algorithm exploits the input redundancy to take into account soft constraints associated with physical saturation limits of the actuators, and also induce reduced energy consumption. The actuator dynamics is fully taken into account in the framework and a rigorous proof of asymptotic tracking of time-varying references is guaranteed despite the impossibility of an instantaneous force execution. The experiments on the ROSPO platform clearly show the practicability and effectiveness of the proposed approach, as well as its scalability with different degrees of overactuation levels
A control architecture for multiple drones operated via multimodal interaction in search & rescue mission
No full textAn architecture suitable for the control of multiple unmanned aerial vehicles deployed in Search & Rescue missions is presented in this paper. In the proposed system, a single colocated human operator is able to coordinate the actions of a set of robots in order to retrieve relevant information of the environment. This work is framed in the context of the SHERPA project whose goal is to develop a mixed ground and aerial robotic platform to support search and rescue activities in alpine scenario. Differently from typical human-drone interaction settings, here the operator is not fully dedicated to the drones, but involved in search and rescue tasks, hence only able to provide sparse and incomplete instructions to the robots. In this work, the domain, the interaction framework and the executive system for the autonomous action execution are discussed. The overall system has been tested in a real world mission with two drones equipped with on-board cameras
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