638 research outputs found
Liquid-liquid phase transitions in tetrahedrally coordinated fluids via Wertheim theory
No full textNetwork interpenetration has been proposed as a mechanism for generating liquid−liquid phase transitions in one component systems. We introduce a model of four coordinated particles, which explicitly treats the system as a mixture of two interacting interpenetrating networks that can freely exchange particles. This model can be solved within Wertheim’s theory for associating fluids and shows liquid−liquid phase separations (in addition to the gas−liquid) for a wide range of model parameters. We find that originating a liquid−liquid transition requires a small degree of interpenetrability and a preference for intranetwork bonding. Physically, these requirements can be seen as controlling the softness of the particle−particle interaction and the bond flexibility, in full agreement with recent findings [Smallenburg, F.; Filion, L.; Sciortino, F. Nat. Phys. 2014, 10, 653]
Lucien Filion Interview
No full textLucien \u27Red\u27 Filion was born in Beaulac-Garthby, QC, in 1915. His parents were farmers, living off the land. In 1923, Red\u27s family moved to Lewiston, Maine. Red started work at 16 in a Lewiston shoe shop, as a \u27cotton boy\u27, bringing raw cotton to the women working the looms. In this interview he describes conditions in the mills, the great shoe strike of 1937, and his career in various Lewiston factories.https://digitalcommons.usm.maine.edu/fac-interviews-and-lectures/1018/thumbnail.jp
RE: Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome
No full textNo abstract availabl
Biotic disturbance in expanding subarctic forests along the eastern coast of Hudson Bay
No full textThe past and present occurrence of insect disturbance on white spruce (Picea glauca) trees was evaluated at their northern range limit on the eastern coast of Hudson Bay, and its effects on tree growth and population dynamics studied.
Three sites were sampled along an altitudinal gradient. Ring-width chronologies and stem analysis were used to evaluate tree growth. The occurrence of holes in the bark, of resin pockets and blue-stain fungi, and ring-width evidence for growth releases were used to assess the impact of bark beetle.
The white spruce population was established at these sites in the 17th century. Since their establishment, the spruce trees have developed a tree growth form, except at the uppermost site, where severe growth suppression occurred in the 19th century. Bark beetle and blue-stain fungi occurred with different timing and intensity. Their highest occurrence, associated with high mortality rates, was at the lowest site in the late 20th century. In the uppermost sites, biotic disturbance has occurred since the 18th century, associated with evidence for mechanical disturbance.
The simultaneous arrival of white spruce in the area resulted in a synchronous onset of spruce beetle activity driven by tree ageing. Unfavourable climatic conditions affected tree growth severely in the most exposed sites
Correction: Filion, G.J. Analytic Combinatorics for Computing Seeding Probabilities. Algorithms 2018, 11, 3
No full textThe author wishes to make the following correction to this paper [...
Caractérisation de l'agent de biocontrôle Pseudomonas fluorescens LBUM223 par l'étude comparative de son interaction avec deux agents pathogènes de la pomme de terre
No full text"Le mildiou et la gale commune sont deux maladies d'importance chez la pomme de terre pour lesquelles aucune méthode n'est totalement durable pour contrôler les agents pathogènes responsables : Phytophthora infestans et Streptomyces scabies. Dans ce contexte, le biocontrôle, qui est l'utilisation de microorganismes conférant une défense accrue contre des agents phytopathogènes, apparaît comme une alternative écologique de choix. La production d'un composé antimicrobien, l'acide phénazine-1-carboxylique (PCA) par certaines bactéries appartenant aux Pseudomonas spp, isolées au sein du laboratoire, semble être un facteur clé du potentiel de ces mêmes bactéries à être utilisées comme agents de biocontrôle contre ces deux maladies. Pseudomonas fluorescens LBUM223 et son mutant isogénique non producteur de PCA sont utilisés dans cette thèse dans le but d'étudier l'impact de LBUM223 et sa production de PCA sur les transcriptomes de P. infestans et S. scabies. Les analyses transcriptomiques de ces deux agents pathogènes sont réalisées grâce à l'utilisation de la technique de RNA-Seq à la suite de tests de confrontation in vitro et la validdation de l'expression de gènes d'intérêt par RT-qPCR. Les résultats obtenus ont démontré que chacun des deux agents pathogènes a subi des changements importants au niveau de son transcriptome à la suite de l'exposition à LBUM223 ou l'agent de PCA synthétique, impliquant des changements transcriptionnels dans des fonctions métaboliques comme le transport, l'oxydoréduction et la pathogénèse. Mots clés: Pseudomonas fluorescens, Phytophthora infestans, Streptomyces scabies, biocontrôle, RNA-Seq, microbiome, pomme de terre."--Sommaire.statement of responsibility: Roxane Roquigny.Thèse présentée à la Faculté des études supérieures et de la recherche en vue de l’obtention du doctorat en sciences de la vie.thesis: Ph. D. (sciences de la vie) Université de Moncton 2018bibliography: Comprend des références bibliographiques : feuilles 233-247.additional physical form: Également disponible en version électronique. Les pages contenants des informations personnelles ne sont pas reproduites.language: Thèse rédigée en anglais, l'inroduction et les résumés de chaque chapitre sont rédigés en français
A atividade empreendedora segundo o modelo de L. J. Filion - Aplicação em micro e pequenas empresas
No full textEste trabalho foi realizado com o objetivo de pesquisar as características de empreendedores
segundo o Modelo de Atividade Empreendedora desenvolvido pelo Prof. Louis Jacques Filion
e aqui foi detalhado conforme os elementos que o caracterizam.
Foram analisados conceitos de empreendedor e empreendedorismo conforme diversos autores
e verificou-se a importância das micro e pequenas empresas para o desenvolvimento da
economia, gerando emprego e renda para grande parte da população economicamente ativa.
Para avaliar o modelo foram realizadas entrevistas com cinco empreendedores considerados
de sucesso e que se estabeleceram em setores de negócio diferentes, porém, todos em
pequenas empresas. Eles foram submetidos a uma entrevista que se baseou em um
questionário com as questões definidas no modelo de Filion.
Como conclusão, pode se dizer que os casos estudados apresentaram uma boa reaplicação do
modelo, especialmente para empreendedores que iniciaram seu negócio já com alguma
experiência profissional
Quittance de Jean-Baptiste Filion et Marie-Louise Parent à Herman W. Ryland
No full text4 pages, copie manuscriteCe document est un acte notarié rédigé par le notaire Jacques VoyerQuittance de Jean-Baptiste Filion et Marie-Louise Parent à Herman W. Ryland pour le paiement de 25 livres sur l'achat des droits de Marie-Louise Parent, l'héritière d'un cinquième de la succession de [Marie-] Reine-Geneviève Avis[se] et Pierre Maheu, dans trois terres que Maheu et Avis[se] ont données, sous réserve, à [A. -L. ] Juchereau Duchesnay. Greffe de Jacques Voyer
Erasing no-man's land by thermodynamically stabilizing the liquid-liquid transition in tetrahedral particles
No full textOne of the most controversial hypotheses for explaining the origin of the thermodynamic anomalies characterizing liquid water postulates the presence of a metastable second-order liquid-liquid critical point located in the 'no-man's land'. In this scenario, two liquids with distinct local structure emerge near the critical temperature. Unfortunately, as spontaneous crystallization is rapid in this region, experimental support for this hypothesis relies on significant extrapolations, either from the metastable liquid or from amorphous solid water. Although the liquid-liquid transition is expected to feature in many tetrahedrally coordinated liquids, including silicon, carbon and silica, even numerical studies of atomic and molecular models have been unable to conclusively prove the existence of this transition. Here we provide such evidence for a model in which it is possible to continuously tune the softness of the interparticle interaction and the flexibility of the bonds, the key ingredients controlling the existence of the critical point. We show that conditions exist where the full coexistence is thermodynamically stable with respect to crystallization. Our work offers a basis for designing colloidal analogues of water exhibiting liquid-liquid transitions in equilibrium, opening the way for experimental confirmation of the original hypothesis
Regulatory monokines in multiple sclerosis and the effects of IL-10 and IFN-ß1a on their levels.
No full textMultiple Sclerosis (MS) is a chronic, autoimmune disease of the central nervous system. MS is believed to be a Th1 inflammatory disease, speculated to be mediated by CD4+ T lymphocytes. The specific contribution of monokines to disease has not been extensively studied in MS. I thus hypothesize that Th1 regulatory monokine levels are elevated in MS patients, and these increased levels correlate to disease severity. This project deals with the quantitation of regulatory monokine mRNA and protein levels in MS patients and their subsequent comparison to healthy control levels. The influence of cytokine-directed immunotherapy, specifically IFN-beta1a and IL-10, on these monokine levels is also addressed. Highly enriched monocytes were isolated and separately cultured for 24 hours in the presence of RPMI media alone, or supplemented with IFN-beta1a or IL-10. Protein and mRNA levels were determined for various monokines by intracellular staining, ELISA, and Riboquant RNase Protection Assay. Increased monokine levels of IL-1, IL-6, IL-12, and TNF-alpha were found to correlate significantly with increased MS disease severity as compared to healthy control levels. IL-10 and IFN-gamma were also detected in MS patient samples, however these levels did not differ significantly from healthy control levels. IL-10 24-hour exposure was found to significantly reduce all elevated MS patient monokine levels. IFN-beta1a showed minimal effects in reducing elevated MS patient monokine levels, and in certain patients boosted their Th1 and proinflammatory monokine levels. These findings suggest a role for monocytes and monokines in the immunopathogenesis of MS, and also indicate further study into IL-10 as a potential MS therapy may be warranted
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