1,721,058 research outputs found
Differential effects of beta-blockers in patients with heart failure - A prospective, randomized, double-blind comparison of the long-term effects of metoprolol versus carvedilol
Full text linkBackground-Both metoprolol and carvedilol produce hemodynamic and clinical benefits in patients with chronic heart failure; carvedilol exerts greater antiadrenergic effects than metoprolol, but it is unknown whether this pharmacological difference results in hemodynamic and clinical differences between the 3 drugs. Methods and Results-We randomized 150 patients with heart failure (left ventricular election fraction less than or equal to 0.35) to double-blind treatment with either metoprolol or carvedilol. When compared with metoprolol (124+/-55 mg/d), patients treated with carvedilol (49+/-18 mg/d) showed larger increases in left ventricular ejection fraction at rest (+10.9+/-11.0 versus +7.2+/-7.7 U, P=0.038) and in left ventricular stroke volume and stroke work during exercise (both P<0.05) after 13 to 15 months of treatment. In addition, carvedilol produced greater decreases in mean pulmonary artery pressure and pulmonary wedge pressure, both at rest and during exercise, than metoprolol (all P<0.05), In contrast, the metoprolol group showed greater increases in maximal exercise capacity than the carvedilol group (P=0.035), but the 3 drugs improved symptoms, submaximal exercise tolerance, and quality of life to a similar degree. After a mean of 23+/-11 months of follow-up, 21 patients in the metoprolol group and 17 patients in the carvedilol group died or underwent urgent transplantation. Conclusions-The present study demonstrates that during long-term therapy, carvedilol improves cardiac performance to a greater extent than metoprolol when administered to patients with heart failure in the doses shown to be effective in clinical trials. These differences were likely related to a greater antiadrenergic activity of carvedilol
Lunghezza dei telomeri e numero delle cellule progenitrici endoteliali: nuovi fattori di rischio e di progressione delle malattie cardiovascolari.
No full textComparisonin terms of handling and performance between two new leads for left ventricular pacing through coronary sinus Medtronic 4191 and Guidant easy-track
No full textValutazione ecocardiografica prima della terapia resincronizzante: quali parametri tra i numerosi proposti dalla letteratura predicono il reverse remodeling
No full textEfficacy and tolerability of long-term beta-blocker therapy in the patients with heart failure and concomitant diabetes mellitus
No full textDoes radiofrequency ablation improbe qualità of life also in patients with class 2 indication?
No full textComparisonin terms of handling and performance between two new leads for left ventricular pacing through coronary sinus Medtronic 4191 and Guidant easy-track
No full textRuolo attuale degli inotropi non digitalici nel trattamento acuto e cronico dell’insufficienza cardiaca.
No full textImportance of operator experience in reducing fluoro-time during biventricular device implantation
No full textProprietà elastiche dell'aorta ascendente in una popolazione di pazienti con deficit di alfa1-antitripsina (genotipo ZZ).
No full text- …
