1,721,096 research outputs found
Le prospettive di sviluppo dell’Area Flegrea nella percezione dei policy maker locali
No full textIl capitolo analizza le principali politiche di sviluppo attuabili nell'area flegrea nella percezione dei policy maker locali intervistati nell'ambito del progetto di ricerca coordinato dal Prof. L. Cantone (gli 8 sindaci dei comuni ed i 4 presidenti di circoscrizione di Napoli afferenti all'area flegrea, come definita nell'ambito del progetto)
EPIGENETIC MARKERS IN ENVIRONMENTAL AND OCCUPATIONAL STUDIES
Full text linkIn the last few years, several investigations have examined the relation between exposure to environmental/occupational and epigenetics and identified several toxicants that modify epigenetic marks. Environmental and occupational exposure to inhalable particulate matter (PM) has been associated with increased risk of lung cancer. Epidemiologic and in-vivo studies suggest that the metal components of PM may be responsible for PM health effects, including lung cancer. Recent in-vitro studies have shown that carcinogenic metals cause DNA methylation and posttranslational epigenetic modifications of histone proteins, thus derailing the normal programming of gene expression . However, whether metals in inhalable air particles induce alterations of histone modifications and DNA methylation in human subjects has never been evaluated. However, whether metals in inhalable air particles induce alterations of histone modifications and DNA methylation in human subjects has never been evaluated.
In the present work, we investigated both short- and long-term effects of particle exposure on histone modifications and DNA methylation in workers with well-characterized exposure to a wide range of PM level in a foundry steel plant.
We measured Histone 3 Lysine 4 (H3K4) dimethylation and Histone 3 Lysine 9 (H3K9) acetylation and DNA methylation in Alu and long interspersed nuclear element-1 (LINE-1) repetitive elements – as a surrogate of genome-wide methylation content – in peripheral blood leukocytes from foundry workers with well-characterized exposure.
Our results indicate that exposure to some metal components of PM, including nickel and arsenic , increased H3K4 dimethylation and H3K9 acetylation in blood leukocytes from a population of healthy steel workers. These changes in the genomic levels of histone modifications may produce aberrant activation of gene expression which may help explain the carcinogenic properties of inhalable nickel and arsenic.
We showed also, for the first time, that PM exposure is associated with altered blood DNA methylation patterns that reproduce epigenetic changes found in cardiovascular disease, including decreased methylation in Alu and LINE-1 repetitive elements.
Further studies are required to directly link these changes with exposure-related increases in the risk of cancer, as well as to identify specific genes and pathways that are affected by the exposure-related changes in histone modifications and DNA methylation
Correction: Normalization strategy for the LC-MS bioanalysis of protein kinetics assays via internal proteolytic analyte utilized as control standard: application in studies of HIV-1 protease cleavage of HIV-1 Gag polyprotein in HIV maturation inhibition research
No full textCorrection for ‘Normalization strategy for the LC-MS bioanalysis of protein kinetics assays via internal proteolytic analyte utilized as control standard: application in studies of HIV-1 protease cleavage of HIV-1 Gag polyprotein in HIV maturation inhibition research’ by Joseph L. Cantone et al., Anal. Methods, 2017, DOI: 10.1039/c7ay01666b.</p
The role of experience in the branding strategies
No full textIn the last years, some marketing studies have focused on understanding brand experience, defined as the customer responses evoked by brand-related stimuli. The aim of this paper is to analyze in-depth the role of the brand experience in consumer-brand relationships, studying this concept and measuring the antecedents and the consequences of it. Coherently, it’s set up a conceptual model for examined the relationships among four brand constructs: brand experience, brand knowledge, word-of-month, brand preference. An empirical research has been camped out to measure: 1. brand experience as perceived by youth Italian consumers for thirteen product categories; 2. the strength of the relationships among brand experience, its antecedents and consequences, as recognized in conceptual model; 3. if and how the brand experience has effects on its consequences more positively for a selected group of brands, defined experiential brands
Valore delle relazioni con i clienti e vantaggio competitivo delle imprese
No full textIl contributo analizza il ruolo della gestione strategica delle relazioni con i clienti nel perseguimento del vantaggio competitivo delle impres
Gestione strategica delle relazione con i clienti e vantaggio competitivo delle imprese
No full textIl paper analizza il ruolo della gestione strategica delle relazioni con i clienti nel perseguimento del vantaggio competitivo delle imprese
Le relazioni tra il comportamento d’acquisto del consumatore e le basi cognitive del valore di marca
No full textIl paper analizza le relazioni tra il comportamento d’acquisto del consumatore e le basi cognitive del valore di marca. A tal fine, nel lavoro è stata effettuata una ricerca empirica su un campione di consumatori di marche di scarpe sportive e servizi di telefonia mobile a valore aggiunto (VAS), finalizzato a valutare le correlazioni esistenti tra i principali descrittori elementari dei due costrutti analizzati prima citati
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Strategie di sviluppo delle destinazioni turistiche e ruolo della marca territoriale
No full textL'articolo tratta il tema della creazione e gestione della marca delle destinazioni turistiche
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