1,721,037 research outputs found
Rassegna sintetica sullo spazio extracellulare cerebrale determinato con metodiche biochimiche.
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A short review of cognitive and functional neuroimaging studies of cholinergic drugs: implications for therapeutic potential.
No full textMetabolic aspects of aging brain and related disorders.
No full textIn this report we summarize some of our findings obtained with single photon emission computed tomography (SPECT) in man and with 19F nuclear magnetic relaxation (19FNMR) and (14C) deoxyglucose ([14C]DG) techniques in animals. 99Tc-hexamethyl-propyleneamineoxime (99Tc-HM-PAO) SPECT showed a pattern of decreased cerebral perfusion in Alzheimer and Parkinson patients without clinical and instrumental signs of cerebrovascular diseases. Rat cerebral cortex superoxide dismutases (SODs) concentrations, as detected with 19FNMR, increased in an age-related fashion. These increases may constitute a self-protecting mechanism of the brain against the parallel elevations of free radical reactions observed during aging. The specific neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elevated ([14C]DG) uptake in catecholaminergic regions of the mouse brain. These effects could be prevented by pretreatment with l-deprenyl. Our results suggest that excitotoxic mechanisms may participate in the neurotoxic effect of MPTP and they can be abolished by the monoamine-oxidase B (MAO-B) inhibitor
Functional responsiveness of the rat brain dopaminergic system: a study with the 14C-deoxyglucose method
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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