1,721,009 research outputs found
Scoring the Space Terror: Music in Science Fiction Cinema during the Italian Economic Miracle
No full textScience fiction became a fashionable ingredient in Italian culture during the 1960s. Once the country entered the economic boom, or “miracle” (c. 1958–1963), the times were ripe for a new cultural sensibility about science’s promises (and threats) to grow. Italian cinema was highly affected by this phenomenon. Rather than developing into a neatly defined genre, sci-fi elements were incorporated into existing genres triggering a variety of configurations in both auteur and popular cinema. In such processes of cross-genre syncretism, music and sound exerted a key role. Our article examines how sound contributed, both from a production and a dramaturgical standpoint, to shaping a highly diversified, “vernacular” sci-fi imagery in Italian cinema. Our analyses include examples from autochthone domestic sci-fi B-movies as well as from comedy and auteur cinema, over a timeframe spanning 1958 to 1965
2',3'-Isopropylidene group, a molecular scaffold to study the activity of adenosine and adenylate deaminase on adenosine analogues modified in the ribose moiety
No full text2',3'-Isopropylidene group can be used as a molecular scaffold for the introduction of modifications at 5' and 1' positions of adenosine and these modified nucleosides are used to evaluate the biocatalytic activity of adenosine and adenylate deaminase
Sintesi di 1-C-metil ribofuranosidi, intermedi per la preparazione di 1'-C-metil ribonucleosidi
No full textDeaminating Enzymes of the Purine Cycle as Biocatalysts for Chemo-enzymatic Synthesis and Transformation of Antiviral Agents Structurally Related to Purine Nucleosides
No full textPurine nucleosides that are modified in the base or the furanose moiety and carbocyclonucleosides or acyclonucleosides often present antiviral activity. Their preparation can involve biocatalytic procedures, including use of deaminating enzymes of the purine cycle such as adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA). These enzymes, that are able to catalyze the hydrolytic deamination of various purine nucleosides and analogues, can be actually considered as valuable biocatalysts in nucleoside chemistry. Applications to the chemo-enzymatic preparation and transformation of compounds endowed with antiviral activity will be reviewed and discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Enzyme-assisted introduction and cleavage of protecting groups in nucleoside chemistry
No full textSynthetic transformations of natural nucleosides and carbocyclic or acyclic analogues require careful choice of methods for introduction/removal of suitable protecting groups. Problems related to chemo-, regio- and stereoselectivity of such transformations, a particularly relevant aspect in nucleoside chemistry, can be adequately solved using a biocatalytic approach. This chapter will illustrate the state of the art in the enzyme-assisted protection/deprotection procedures either in a hydrolytic mode or taking advantage of reactions that can be carried out in organic solvents by suitable lipases
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Synthesis of deuterated isotopomers of 7 alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids.
No full textDeuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from [2,2,3,4,4,6-H-2(6)]-cholesterol and (20S)-[7,7,21,21-H-2(4)]-3beta-(tert-butyldimethylsilyl)oxy-20-methylpregna-5-en-21-ol, respectively
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