237 research outputs found
Journal of a tour through the Highlands of Scotland during the summer of MDCCCXXIX.
No full textPrivately printed for the author by J. Johnstone, Edinburgh; 500 copies only.Added t.-p., engr.: A tour through Scotland.Mode of access: Internet
Idiopathic intracranial hypertension, hormones, and 11ß-hydroxysteroid dehydrogenases
No full textKeira A Markey,1 Maria Uldall,2 Hannah Botfield,1 Liam D Cato,1 Mohammed A L Miah,1 Ghaniah Hassan-Smith,1 Rigmor H Jensen,2 Ana M Gonzalez,1 Alexandra J Sinclair1 1Neurometabolism, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; 2Danish Headache Center, Clinic of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark Abstract: Idiopathic intracranial hypertension (IIH) results in raised intracranial pressure (ICP) leading to papilledema, visual dysfunction, and headaches. Obese females of reproductive age are predominantly affected, but the underlying pathological mechanisms behind IIH remain unknown. This review provides an overview of pathogenic factors that could result in IIH with particular focus on hormones and the impact of obesity, including its role in neuroendocrine signaling and driving inflammation. Despite occurring almost exclusively in obese women, there have been a few studies evaluating the mechanisms by which hormones and adipokines exert their effects on ICP regulation in IIH. Research involving 11ß-hydroxysteroid dehydrogenase type 1, a modulator of glucocorticoids, suggests a potential role in IIH. Improved understanding of the complex interplay between adipose signaling factors such as adipokines, steroid hormones, and ICP regulation may be key to the understanding and future management of IIH. Keywords: 11beta-hydroxysteroid dehydrogenase type 1, steroid and adipokines, obesity, lepti
Compte-rendu d’un entretien effectué avec Christophe Botfield, conseiller pédagogique du service d’éducation physique et du sport du canton de Vaud
No full textL’onglet « EPS à domicile COVID-19 » du site du SEPS contient divers thèmes par ordre alphabétique (coordination, danse, divers, endurance, étirements, liens, relaxation, renforcement musculaire, théorie), dans lesquels sont déposés des documents pédagogiques avec l’intitulé de l’activité ainsi que le cycle visé. Ces documents ont diverses formes : documents écrits, capsules vidéo, défis à effectuer, notammen
Time-resolved measurements of sugar-binding-induced conformational changes in the melibiose permease from Escherichia coli
No full textThe melibiose permease (MelB) of E.coli functions as a secondary-active symporter by using the electrochemical H+, Na+, or Li+ gradient to accumulate, e.g., melibiose [review in Pourcher et al. 1990a]. The global and primary objective of this thesis was to apply pre-steady state methods for the investigation of reaction rates of individual steps in the cycle of MelB. Especially the melibiose binding induced transition was investigated by the solid-supported membrane (SSM) technique [Seifert et al. 1993] in combination with a rapid solution exchange system [Pintchovius and Fendler 1999] and with the Stopped-flow technique [Roughton 1934]. To approach this goal, either wild-type or mutated MelB were purified and reconstituted into liposomes as described [Pourcher et al. 1995]. Although the orientation of the proteins is a critical factor for the activity of MelB, it was, so far, unknown. To determine the orientation of the proteins in the liposomes, single Cys mutants R139C and R141C [Abdel-Dayem et al. 2003] were selectively labeled with 3-(N-maleimidylpropionyl)biocytin (MPB) and analyzed by SDS-PAGE and Western Blot. The assay indicated that most of the proteins are inside-out (ISO) oriented permitting to relate the pre-steady state electrical and fluorescence signals to the reverse transport activity of MelB. The melibiose induced electrical signal was investigated in wild-type MelB with the SSM technique. The transporter was activated by a substrate concentration jump, and transient currents were measured. When the transporter was preincubated with Na+ at saturating concentrations, a charge translocation in the protein upon melibiose binding could still be observed. This result demonstrates that binding of the uncharged substrate melibiose triggers a charge displacement in the protein. Further analysis showed that the charge displacement is neither related to extra Na+ binding to the transporter, nor to the displacement of already bound Na+ within MelB. Electrogenic melibiose binding is explained by a conformational change with concomitant displacement of charged amino acid side chains and/or a reorientation of helix dipoles. A kinetic model is suggested, in which Na+ and melibiose binding are distinct electrogenic processes associated with approximately the same charge displacement. Melibiose binding is fast in the presence of Na+ (k > 50 s-1). Furthermore, two previously identified transport deficient mutants of loop 4-5, R141C and E142C [Abdel-Dayem et al. 2002, Séry 2002], were purified and extensively studied with the SSM. Whereas the electrical signals from control cysteine-less mutant showed a bi-exponential time course of decay, those from R141C or E142C consisted of only a single fast exponential component, and the slow decaying component associated with substrate translocation was missing. The electrical signals evoked by a melibiose concentration jump in the presence of Na+ were much smaller than the corresponding signals in C-less MelB. Furthermore, R141C lost the stimulating effect of melibiose on Na+ binding. Steady-state Trp fluorescence spectroscopy revealed impaired conformational changes after melibiose binding in the mutants and fluorescence resonance energy transfer (FRET) measurements indicated that the mutants still show cooperative modification of their sugar binding sites by Na+. These data suggest that loop 4-5 contributes to the coordinated interactions between the ion- and sugar binding site and participates in conformational changes after melibiose binding that are essential for the subsequent obligatory coupled translocation of substrates. By using the Stopped-flow technique, three different approaches were followed. First, the intrinsic Trp fluorescence of MelB, known to increase upon melibiose binding [Mus-Veteau et al. 1995], revealed a signal with a T 1 of ~15 ms in C-less. This time constant is of the same order of magnitude as that determined with the SSM method suggesting that Trp fluorescence and electrical signal are related processes. Conformation for this assumption came from the fact that the activation energies Ea for both processes are similar (around 45 KJ/mol). Second, by using the fluorescent sugar analog Dns2-S-Gal, which monitors events close to the sugar binding site [Maehrel et al. 1998], a signal with a T 1 of ~18 ms was recorded upon Na+ addition. Finally, the fluorescent dye MIANS was used to selectively label the single Cys mutant E365C of loop 10-11. Stopped-flow measurements revealed a melibiose-induced fluorescent signal with a T 1 of 45 ms. Since electrical measurements with the MIANS-labeled E365C excluded the possibility that the label is responsible for the slower kinetics, the conformational change detected by the MIANS fluorescence was assigned to a slow transition in the cycle of MelB after melibiose binding. Ea was determined to be 96 KJ/mol corroborating, thus, the hypothesis of a different process. In conclusion, it was possible to correlate the electrical and fluorescence signals to partial reactions of the transport cycle and to determine their rate constants. According to this new model, the melibiose-induced signal detected with the Trp and electrical measurements corresponds to a step preceding the carriers’ reorientation (3 3*, k ~ 65s-1), and the melibiose-induced signal detected with the MIANS fluorescence to the reorientation itself (3* 4, k ~ 20s-1).Um die Aufnahme und Abgabe von organischen Substraten und Ionen in die Zelle zu ermöglichen, besitzt die Plasmamembran eine Reihe von verschiedenen Transportsystemen. Die Melibiose Permease (MelB) in der zytoplasmatischen Membran von Escherichia Coli ist ein solches Transportsystem und gehört zur Familie der Glykosid-Pentosid-Hexuronid-Transporter. MelB besteht aus 473 Aminosäuren und hat ein Molekulargewicht von 53 kDa. Das Protein ist sehr hydrophob (70% apolar) und hat zwölf Transmembrandomänen mit alpha-helikaler Konformation [Botfield et al. 1992, Gwizdek et al. 1997, Hacksel et al. 2002, Pourcher et al. 1990a]. Der Transport verschiedenster Substrate durch biologische Membranen ist an bereits existierende Gradienten anderer Substrate oder Ionen gekoppelt (sekundärer Transport). So nutzt zum Beispiel MelB den durch andere Systeme geschaffenen elektrochemischen Natriumgradienten, um akkumulierend ein Substrat (zum Beispiel alpha-Galaktoside wie Melibiose oder beta-Galaktoside wie Methyl-1-thio-beta-D-galaktopyranosid) in die Zelle zu befördern. MelB kann als kotransportierende Ionen neben Natrium auch Lithium und Protonen verwenden [Bassilana et al. 1985, Lopilato et al. 1978, Pourcher et al. 1995, Tsuchiya et al. 1978, Tsuchiya et al. 1980, Tsuchiya et al. 1983, Tsuchiya & Wilson 1978, Wilson & Wilson 1987]. Die Kosubstrate binden an den Transporter mit einer Stoichiometrie von 1:1. Des weiteren erhöht die Bindung des Kations die Affinität des Transporters für den Zucker, wobei Na+ und Li+ bessere Aktivatoren als H+ sind. MelB katalysiert die gekoppelte Translokation von Na+ (H+ oder Li+) und Zuckern ebenfalls mit einer Stoichiometrie von 1:1. Die Substratbindung an der Außenseite und die Substratdissoziation ins Zytoplasma erfolgen geordnet, d. h. Na+ bindet zuerst gefolgt von Zucker, wohingegen der Zucker zuerst dissoziiert gefolgt von Na+ [Bassilana et al. 1987, Damiano-Forano et al. 1986, 1988, Pourcher et al. 1990a]. Dabei erhöht das Membranepotential den aktiven Transport, indem es die Rate der Na+-Dissoziation in das Zytoplasma erhöht. Wenn Melibiose in der Zelle ist, wird es von der alpha-Galaktosidase in Glukose und Galaktose gespalten, die beide von der Zelle verstoffwechselt werden und der Energieproduktion dienen. MelB ist ein besonders interessantes Protein für die Untersuchung des Transport-mechanismus, da es verschiedene Zucker und Kationen als Substrate nutzt. Außerdem läßt das Protein sich in großen Mengen herstellen, aufreinigen und in Liposomen rekonstituieren [Pourcher et al. 1995]. Die Melibiose Permease besitzt strukturelle und funktionelle Homologie zu anderen Na+-/Substrat-Kotransportern, die bei biologisch und medizinisch relevanten Prozessen wichtige Funktionen einnehmen. Trotz ihrer Bedeutung sind die Kenntnisse zur Struktur und Funktionsweise dieser Transportproteine sehr begrenzt und deren Aufklärung bleibt weiterhin eine große Herausforderung. MelB dient dabei als Modell, die zugrundeliegenden molekularen Mechanismen sekundär aktiver Na+-Kotransporter besser zu verstehen. Damit können generelle Prinzipien zur Funktionsweise formuliert werden, die auch auf eukaryotische Transporter angewandt werden können, die bei pathophysiologischen Prozessen eine Rolle spielen. Bisher wurden hauptsächlich stationäre Messungen durchgeführt, die einen Einblick in den Gesamtreaktionsmechanismus von MelB gegeben haben [Pourcher et al. 1990a]. Vor kurzem wurden elektrogene Vorgänge, die durch die Aktivität von MelB verursacht worden sind, zum ersten Mal untersucht [Ganea et. al. 2001]. Hierzu wurden Proteoliposomen, die den gereinigten MelB-Transporter enthielten, auf eine festkörperunterstützte Membran (SSM) adsorbiert. Diese Technik ist besonders interessant, da mit Hilfe eines schnellen Lösungs-wechsels Konzentrationssprünge von nahezu jedem beliebigen Substrat an der SSM durchgeführt werden können. Bei dieser ersten Charakterisierung wurde festgestellt, daß die Na+-Bindung an MelB eine Ladungsverschiebung innerhalb des Proteins auslöst, die sich in einer schnell abfallenden Komponente eines transienten Stromsignals widerspiegelt. Mehrere Zwischenschritte innerhalb des Reaktionszyklus wurden bisher nicht oder nur ungenügend charakterisiert. Deswegen bestand die grundlegende Zielsetzung dieser Arbeit darin, vorstationäre, oder pre-steady state Methoden, zur Untersuchung einzusetzen. Diese erlauben es, Reaktionsgeschwindigkeitskonstanten von einzelnen Schritten im Reaktions-zyklus von MelB aufzulösen. Um dieses Ziel zu erreichen, wurden der Wildtyp und verschiedene mutierte Transporter solubilisiert, aufgereinigt und anschließend in Liposomen rekonstitutiert, wie es bereits für MelB beschrieben worden ist [Pourcher et al. 1995, Rigaud et al. 1995]. Die Methode der Aufreinigung und Rekonstitution hat den Vorteil, daß man ohne Wechselwirkung mit anderen zellulären Proteinen die Eigenschaften von MelB untersuchen kann. Die Proteoliposomen wurden in dieser Arbeit hauptsächlich mit der SSM und der Stopped-Flow-Technik untersucht. ..
6
No full textSILVER CORNET BAND. !
s.
Papers of incorporation are be-1
ing made out to incorporate the
Palo Alto Silver Cornet Band.
There will be 500 shares issued of
which the members will probably
take 10 shares each. Thc remaining shares will be sold at a dollar
a share.
Thc Band will own its own instruments, as a whole, aud thus
make good security lor all outstanding stock. After the organization gets thoroughly established
it is the intention to buy in all
this stock which will put the
corporation on a solid foundation.
An instructor will be employed at
once aud the Band expects to be
practicing in earnest by next
week.
The officers, directors, and the
members and the instruments they
play arc as follows. .
OFFICERS.
President—E. A. Hettinger.
Secretary—W. Werry.
Treasurer—H. I). Botfield.
Leader—H. Downing.
Librarian—Bert Quinu.
DIRECTORS.
E. A. Heitinger VV. Werry
H. D. Botfield H.'Uowning
G. L- Merguire Mr. Simpson
E. Wilson.
MEMBERS AND T1JE INSTRCMENTS
THEY MAXirCLATE.
E. A. Hettinger—Comet.
G. L. Merguire— "
H. Downing— "
H. Hanson— "
E. Bushuell — Alto.
Bert Quinrj— "
G. Rosebrook — Tenor.
G. -.Parkinson— "
W. Werry—
E. C. Thoils—
Mr. Wilson — Baritone.
Mr. Simpson — Tuba.
H. Botfield—Snare Drum.
Ray Starbird—Bass Drum.
Some years _ago the Band was
organized aud made a reputation
that has not been forgotten, brt
owing to some of the members
removing elsewhere they disbanded. The reorganization I
will be a valuable addilion to the
many other attrations of Palo
Alto.
Warranted Garden Hose at!
Parkinson's.
Our fall and winter stock will;
bc here next week. We invite j
your inspection, Fishinan's May-
field.
Try those West Virginia Stogies at L'irkiu's cigar store. *
A Modern
11 room
Dwelling
Bath, Electric Lights, Furnace etc.
Situated
on
• one of
the Principal
Streets
of
Palo Alto
For Sale Cheap
E G DYER & CO
Real Estate- Insurance agents
IDEALS, fitted with "G. & J." Tiers30
i
} We have a complete line
of Photo supplies and
f Ui cycle sundries.
F. "l. crandall
la a ALLH*_j)il and Gasoline
,ith L.ui. Data!, stoves and plumbing, fniscrstly Avenue. Aalo Alio
Order boxes; University P. O. and near P. O. Menlo Park
5 to $3,-)
An ideal p.nee for City people who wi*h
pi ens am out-o.-tuv._t quarlcrs for the summer
at R-ayn-Mc Riles
wmam
Board *
and taht*-PA10 ALTO HOTEL
Rooms
Its the skill 01 putting together
as much as thc proper ingredients
that makes a prescription right.
Better go to the
Palace Pharmacy.
Dr. II. D. Kellogg,
Manager
oms ■**-*:
MrVWs
JWN ^^^
Can accomodate clerks and mechanic..
Call or address
Mrs. C. Keene, paVLto
HAY, GRAIN AND
FRENCH STEAM LAUNDRYI:«.:
Satisfactory Work at Reasonable Rates
MOUROT & CO. - Redwood City,
Agenle for Tlie F. Thac-as Turieian D, lug and Cleaning Work. 27 Tenth
Street, San Francisco.
MILLSTUFFS
G. W. LA PEIRE i SON
COAL
NATURAL ICE
Palo Alio Feed, Fuel and Express Go.
Alm» Street, Opposite .the 8. P. Brclgt1 Depc
F, L. "WORRELL, PROP
Dealers in-
ThrCinet Burj»e__of Milesbutyri, Pa.,
Bavi* DeWitt'a Karly Kici-re are tho Imjsi
pijifi that he ever used in hit? family fer ,
forty year, pant of houpekeepinj*. They j
cure constipation, siek headache anil j
atomai-h and liver trim.-!,-**. Small
PALO BLTO JWUTUflL
LDING & L
Association
Incorporated 189*.*
^S. BUTLER.. Pre.i-*rDl
ii* Mary Gar--., Vice President
Bank of Pnlo Alto_ „ _..Treasurer
i-xtrph Hnt.htn*OD_ Atiofnty
! art. hall u!_ck «_ Secretary
D1R1.CTOKS—1>- L. Sloan, J. S. Butler, G.
W. Mofhcr, MfM Mary Garcn. Norfis H.
Smith, W, w. Trucfdalc. W B. NorrU, C. A.
Moshcr, Joseph flutchinso-.
A series of free Shares
is Issued QUARTERLY
Giving to Investors the Fut' ...-.riiings
of ttie AssociatiO'
Loans made on Mortgages for lilding
pnrposes
INTEREST Paid in quarterly diTidends
on term deposit 8
Call at the o(-c* of the Secretary for full
Information,
Provisions, Crockery.Glass-
ware,\Vood & Willow-ware
WHEAT, CORN, BRAN & BARLEY
Fresh Butter and Eggs a Specialty
GIVE US A CALL IN OUR
NEW STORE ON RAMONA STREET
Palo Alto Mayfield
■ii."lmi'-*re«t in'rssaulM.-I'alacc lMiAr'm PalO AltO 1 railSIfir LO
«cy. w. II. Ealloat.
The fashion
f. a. mu-iikb, Pri.*- rit-tor,
■****--■ n'-rt-.— _L ■_______*__ Ns-tt Trurb fur PlAtiv Tloslnc
&_aa-vi_a.gr * .-Parlors i
BAGGAGE PROMPTLY DELIVERED
(special Attention to Ft-rnHure Uo-ing,
All work .-arefntly anJ neatly don*
fcy i x\ i ru-iH-fd norknien.
U*. §, NLA DP,
N'-»! to the Palo Alio Bask. I'ruprl-ior
OP PICK:
Varrer.it. are. ■••!•__-*■ Milliard Parlo
;do not lose your vote
Notice of Registration of Voters
Ot-** of the County Clcrt v
of Santa Clara County, Cal.
NOTICE IS HEREBY GIVEN THAT ALL CITIZENS WHO
ARE NOT NOW ON THE GREAT REGISTER 01-
I Santa Clara County and who wish to vote at the General Election
j to be held November 8, 1898, must register before the 15th
[day of August, 1898. and all voters who have voted in Santa Clara
county since April 13, 1S96, but have removed from the precinct last
voted iu. must have their registration changed before October 12,189s
Further notice is hereby given that affidavits for registration
and for change of precinct may be sworn to before any Deputy County
Clerk in the different towns and precincts of this county without charge
Voters whose names are now on the Great Register of this
county need not register unless since thc date of such legist ration they
have changed their places of residence.
ALL VOTERS are requested lo see that they are registered in
the right precinct before registration closes.
HENRY A. PFISTER, County Clerk.
Dated, July 20,189?. • 7-22-t
An altered-specificity mutation in a human POU domain demonstrates functional analogy between the POU-specific subdomain and phage lambda repressor.
No full text16
No full textCENTURY EDITION PALO ALTO -LIVE OAK
XeaMng Business flhctx of palo Rlto
ATTORNEYS ami NOTARIES
1'UBI.IC-
8. W. (Iiarles
<■. «i. Wigle -
W. K. Norris
BARBEKS-
•I. U. Lorkin
W. C Wfani
SkuteBros.
IIILLIAKIIS-
Farrain &. Slade
l/mis ttraut
BLACKSMITHS—
Mullen & Harms
(',. E. t lilcri'st
BOOKSELLERS ANDSTATIONEUS
Merguire Bros.
; 11. W. Simkins
BRICK und CEMENT WORK—
Its. Downar
A. McLachlan
BUILDING MATERIALS—
Parkinson Lumber and<
J—'. liiirdwamiii. :__
CVCLER1ES-
Orr & Peterson
F. L. (Vandall
' W. H. llusted
DENTISTS- . •
Dr. a W. Decker
Dr. H. D. Dodge
Dr. 0. B: little
druggists—
B. P. Hall
Edw. 0. Webb Jr.
DRY GOODS—
Mrs. (!. (latrander
Ferguson & Co.
FEED AND FUEL—
F. U Worrell
J. K. Plannelly
Downing & Son
t'URNITURK—
F. W. Sherman & Cx>.
C K. Spaulding
Tacoma Mill Co. ~" — ■-
CANDY MANUFACTURERS—
The Spa, Ernest Wilson
A. N. Umphreys
CONTRACTORS AND BUILDEKS-
11. U rpham
G. I-iumKiAtt-r
J. W.'Wells
G. W. Mosher
E. A. Hettinger
GROCERS—
J. C. Black & Son
G. W. La lMere & Son
Earle & ('.
Jordan's Cash Storj
FuUer & Co.
JEWELERS—
H. D. Botfield
1'. I.. Seaman*
LIVERY STABLES—
R. B. Bell's Stables
. 0. N. Reynolds
MEAT AND PISH MARKETS-
(I. J. Carey
James Blake
I. T. Osburn
MERCHANT TAILORS-
F. C. Thiele
A. It. Allison
NEWSPAPERS—
Palo Alto Live Oak
Palo Alto Times "
PAINTERS—
Stroner & Backus
Callahan MacCarthy
PHYSICIANS—
W. W. Gamble, M. D
W. L. Adams, M. D.
C. G. Gordon, M. D.
Howard Black, M. D.
H. H. Pillsbury, M. D.
"iirP: llllshnry, M. Br—
~—Gr E. Hallv M;- D.; ==
PLUMBERS—
IiOuis Dahl
Geo. B. Lucas"
11 A Gairaud
REAL ESTATE—
■'3.3. Morris
John F. Byxbee
• E. G. Dyer & C i.
SHOE DEALERS—
Thoits' Shoe Store
S. ('. Gibson
..MISCELLANEOUS— ...
Bank of Palo Alto
G. H.Parkinson, Cinhler
Palo Alto Hotel
E. M. Allen, Prop.
Marshall Black
Seu'y P. A. HnlMIng mill Loan
' Werry & Son
Transfer und Shipping
Palm Bakery and Royal Coffee C).
V. E. Purkitm, Mgr.
Palo Alto Home Bakery
, Mm. C. E. liurthuluiuuw, Prop.
G. 11. Allen Oil Co.
Daley Express Co.
J. B. IJuloy, Mfc'i-.
Powell & Dean
Piquing Mill
A. M. Carrel
llui-uugf utid S.ulil lory
Curriugu Hep.»sllory
Itestaurant
Win. J'atnek
C. A. Mosher
Express it Ti-aimfer Co,
C. J, Brown
Ca bluet Make
0006
No full text0. X. CONVENTION PROORAM.
The lollowing is an outline of the
program for the County Christian
Endeavor Convention which meets
in Pah. Alto Octolier 21.
Friday, evening at Fraternity
Hall—Reception to visiting Envea-'
vorers.
SATim-AY .IOKNING
Preshylcrian Church, 7 to 8—
"Tbe Morning Watch."
Morning .Session, 9 to 12-Theme:
"Forward. " Music under the direction ol Dr. (i. B. Little.
Convention Chorus—"Loyalty to
Christ." There will also lie several
selections of special music during
the day and evening.
Devotional Exercises—Rev. J.W.
Graybill.
"Welcome"—Marshall Black.
Res-ionsc—Pres. .*.. W. ilili.
PajH-r—Miss Anna Kraser.
Qnwtion Box—Rev. S A. Nesl.it.
Kejiorl of NoniiiilililigCommittee
Pa per—Miss Sorrie L. Cook.
Mission work in Chili—Mrs. Dr.
*" Wagner.
1'iijM'r—Miss Maud Main.
Sunday School be_ Mission Field
—Baric S. Bingham
Detroit Convention.—-Marshall
Black.
Adjournment.
Aftkiisoon Session. 1:80 to ii—
Jos. D. Radford presiding.
Devotional—Rev. I). A. Russell.
Address—Rev. F. II. Mnrr.
(bulk Talk- President Hill.
Our Lookout Committee—Miss
Farwell.
Rest.
Junior Rally. -Miss Edith Hunts
presiding.
Section 1.—Foiwiird movement.
" i Our Boys und Girls for
Christ.
Section II—"Feed My Souls"
Model Intermediate Meeting—W.
G. Alexander presiding.
Three minute reporte by County
Superintendent und Officers.
SATfltllAV KVKM.Ni">.
Methodist Church, 7..SO to 9—
The Passion Play—Dr. D.S. Jordan
illustrated hy sten-opticon views.
Presbyterian Church, 7:.'0 to '.I—
The Holy City—Rev. H. M. Tenny
illustrated by stereoplicon views.
Evening Session, Fraternity Hull
!)—President Hill presiding.
Devotional—G. W. Campbell.
Offertory.
Roll cull" ot societies.
Presentation ol County Banner
— President Hill.
Looking Backward—History ol
County Union—II minute talk by
ex-president ol the Union.
Installation of officers—R'*v. S.
A. Ncsbit.
Consecration— President UUL.
Mil. pah.
Would you like Something
nice in
•' Here are a few prices
Staple & Fancy
o
o
__
to
Soap?
Coquette RoseJ5c
A Special Leader A Handsome Package [
A good Soap j
Dermal Dewl^
and IOC.
Honeymoon [".. _
Just the thing for large B UOZ
households )
id will wii-h well and LAST
Hall's Drug Store
l Ami ■ ity _t ul _lh. (» I t-i]u_ll*r good
(ci|Hiilly che_i>
All our _t*.|»** arc well Dried nod
G
ROCERIE
S
FULLER & CO.
Garden Hose
*
nil grade.
prion to _uit
*
Opposite Bank
L. DAHL
ELITE MARKET
#
Refrigerated and M17 A T^Q
Home Killed*****-"» 1 >*->
Patronise a Boms Market
oji|losile P. II.
Ceo. J. Carey, Proprietor
Try Our
High GradeGoffeeS
RED STAR
mm LAUNDRY
ofSnnJust. for fir^t-class work.
We are local agents for
Golden Gate Brand
Tomorrow night i* the opening
at Fannin A* Sla.le's for the very
best CLAM CHOWDER. Try it..
a frightful-LUNDer.
will ottoi rau». > «•**>-< »»"•■ SC*IJ* -JJ
OtBrul... B_kl«»'aAI»l_S»l«*, —» *—J ™ j
111. world, will kill !»■* l* - **>-P»*» H*«l
11. Cum Old Sor... P.v.r _.,r...CI«l.. So IU.
S.loo., Con., .1" Skin Kuiplioi... B..I ell.
cur.on.arlh. Only il cl». S_ __-gsSfS*
lead, sold by Hall', Pharmacy.
Agents—H. K. Lougheed. Kncina Hall: H. A. Strout, Pain Alto. The
ollice is at W. C. Difani's barber shop where all orders will receive
mid vou will be conviuccd that no prompt attention. Work call for and delivered, either in Palo Alto
or on the campus.
breakfast is complete without our ,
Java I Mocha Blend ||^ J± GIARAUD
Plumbing and Tinning
Steam and Gas Fitting
•♦--General Contracting--*^
AH work 'hu.f promptly un I Bitti___i-.url.1ly
High street, opposite Post office, Palo Alto,
French Laundry
Wasimix mr K»iuiiie. Carefully AtumM to. LACKS ami LACK LTKTAIM
A SPECIALTY
A P4INTAL « %HI» will littn. our l-mimlry Wbr. ti tOJFOttl (I utii
ADDRK . S P HRRfcCOU »'_N_0 P*«
H. D, BOTFIELD--^ "'^'a,,,;' ;
Watches, Clocks, Jeweler^
Cj_ OCCI"S Optical fioods Musical Sii|.]>liv_ Silverware .
University ave. Palo Alto; Fine Watch and Jewelery Repairing
Earle&Co
Men and masculinities in qualitative research on vasectomy: perpetuation or progress?
No full textAlthough vasectomy is a safe and highly effective method of contraception, uptake is variable globally, with scope for increased engagement in high income nations. Very little qualitative research has been published in recent years to explore men’s perspectives on vasectomy, which represents a key opportunity to better understand and strengthen men’s contribution to reproductive and contraception equality. This paper takes a scoping review approach to identify key findings from the small but important body of qualitative literature. Recent masculinities research argues that, despite some expansion in ways of being masculine, an underpinning ethos of masculinist dominance remains. Extant research on men’s attitudes to vasectomy supports this ambivalent picture, indicating that while there are extending repertoires of masculinity for men to draw on in making sense of vasectomy, many remain underpinned by masculinist narratives. There remains scope for education and health promotion ensuring vasectomy is viewed as a suitable and safe option by more men of reproductive age. Increased uptake of vasectomy may also help shift the longstanding social expectation that women take primary responsibility for contraceptive practices, challenging gender discourses on contraception
0008
No full textLOCAL BRIEFS
H. T. Hops of Han Francisco was
in town Wednesday.
A. P- Flower, of Auroia, III. paid
Palo Alto a vit.it the find of the
week.
Professor and Mrs. Karl G.
Rendtorf are .ponding a part of
their honeymoon here.
Professor A. G. Newcomer und
family are 8]»cnding the . innim -r
visiting relatives in Illinois, *4
Rev. W. I>. Bishop iaoerapins
his residence on Waverly street
during tlie summer months.
The members erf the high »cbool
rliitn 'jive the graduates jt nc-ep-
tion at Nortree Hull this evening,
The Workmen gar, an enjoyable
''Smoker" to memb. »of Om* order
and friend.- last Tue.-da;. evening.
Miss E. IS. Pearson has purelms-
ed a lot in block 77 adjoining the
property nf Mis.-. Mary Garen and
will build a small bottte thereon.
Town Marshal Truer-dale is doing
a commendable work in cutting
down the poisonoak which abounds
in tome ofour streets,
A number oi Palo Alto people!
will attend the Methodist picnic at
f-unw't Park. Saturday an excursion leave. San Francisco in thr*
morning.
*Siekle Grinder**. mnething new,
will sharpen a >"i foot knife in 10
minute.-.at ('ami's Harness Carriage and Implement Repository.
Robes and blankets from LOO up
for tbe next 15 days n- Cai :<;'-.
WOULD NOT SUFFER SO AGAIN
FOR FIFTY TIMES ITS PRICE.
I awnk' last night with KVCH
pains in mv stomach. 1 never
felt to badly m all my life. When
I came down to work thi- morning
1 felt st. weak I could lardh walk.
I went to Miller .V Mel i.n.lvV drug
store and the. recomm. nded Cham-
lierlainV Colic, Colera nnd Diarrhoea Uemetlv, It worked like breakfast ia complete without ont
[Eil'Sit lllS. Java & Mocha Blend
hie. I shall ind Ik- ivitl, out it in
mv home ln-rt-nllt-r. fttr 1 should u,,t
care u> endure tbe siiff.-rinj's ,,f lust We "* local agents for
night iiL-iiiti i"t liiiv times its price.
— (i. II. Wilson, I.i v.| vmiili. llur.-
rirZi,^i"'±\."\l'v. Golden Gate Brand
Hall.
MM Co. Violet Ammonia
Staple & Fancy
o
o
o
a
•25c. a pint
A delightful toilet rt
At present we hare a limited supply
of the hall pint trial size for 15c.
Silil only at
6
_ Hall's Drug Store
ROCERIE
S
FULLER & CO.
Garden Hose
Opposite Bank
__£ "" ra''"* ^k-
/V^ I>ri - t.. suit vr~
-—--L. DAHL
C«ILDREISIS
Fine Stock at the Low
REPAIRING Strictly First Class at (jil)SOlVS
TSL.e( nife RED STAR 521 H5
est Prices. 0 IUuO
and you will be convinced that no
Agents—H. K. Lougheed, Enciim Hall: li. A. Strrnit, 1'a.u Alto. The
office is at VV. C. Difani's barber shop where all orders will receive
prompt attention. Work call for and delivered, either in Palo Alto
or on tbe campus.
L. A.GIARAUD
Plumbing and Tinning
Steam and Gas Fitting
*v_ General Contracting^--*
All work done pro,,it.l.y nii-l aati»taetoriaIl.v
I High street, opposite Post office, Palo Alto.
EASTMAN KODAKS
t,l pii-ttirt'
Pocket K„.lak.
l'x-2 * 8
Falcon Kodak, sin oi picture
:',.x:l. *••'•
Folding Pocket, siz,*>i picture
•..x:i| *w
8.xS. *•■'
Folding Bolls Kyi-, si/.,- „i l'it-
iiiii- VA.x'.'A *10
■ Cartriilj.''- Kodaks, sine of pic-
ttir,- btS f-8
5x7 *:'""'
K. I.. t'KANHAI.1. ,_
Pill-bury BUg. Opp, Depot| University ave. Palo Alto, - me
P LARRECOU
French Laundry
YVuhing for F»m..-*** Canffii'ly A
I
A IM.WTA.L « *-HO *
.ACKS ami LACE tTKTA.S*'
g ettr I ■orsitry W*gi.n toyour 4w
ADDRESS f» URMICOU
Grocers
H. D. BOTFIELD^^
& Watches, Clock, Jewelery
Optical I'.o-ils Mit-ira! Snppli.-- -Un
Watch and Jewelery Repairin
- …
