11 research outputs found
Docetaxel Vs. Vinorelbine in Elderly Patients With Advanced Non–Small-Cell Lung Cancer: A Hellenic Oncology Research Group Randomized Phase III Study
No full textSerum Levels of Surfactant Proteins in Patients with Combined Pulmonary Fibrosis and Emphysema (CPFE).
No full textEmphysema and idiopathic pulmonary fibrosis (IPF) present either per se or coexist in combined pulmonary fibrosis and emphysema (CPFE). Serum surfactant proteins (SPs) A, B, C and D levels may reflect lung damage. We evaluated serum SP levels in healthy controls, emphysema, IPF, and CPFE patients and their associations to disease severity and survival.122 consecutive patients (31 emphysema, 62 IPF, and 29 CPFE) and 25 healthy controls underwent PFTs, ABG-measurements, 6MWT and chest HRCT. Serum levels of SPs were measured. Patients were followed-up for 1-year.SP-A and SP-D levels differed between groups (p = 0.006 and p<0.001 respectively). In post-hoc analysis, SP-A levels differed only between controls and CPFE (p<0.05) and CPFE and emphysema (p<0.05). SP-D differed between controls and IPF or CPFE (p<0.001 for both comparisons). In IPF SP-B correlated to pulmonary function while SP-A, correlated to the Composite Physiological Index (CPI). Controls current smokers had higher SP-A and SP-D levels compared to non-smokers (p = 0.026 and p = 0.023 respectively). SP-D levels were higher in CPFE patients with extended emphysema (p = 0.042). In patients with IPF, SP-B levels at the upper quartile of its range (≥26 ng/mL) presented a weak association with reduced survival (p = 0.05).In conclusion, serum SP-A and SP-D levels were higher where fibrosis exists or coexists and related to disease severity, suggesting that serum SPs relate to alveolar damage in fibrotic lungs and may reflect either local overproduction or overleakage. The weak association between high levels of SP-B and survival needs further validation in clinical trials
Composite Physiological Index (CPI) correlations to A. SP-A, B. SP-B, C. SP-C and D: SP-D.
No full textLevel of statistical significance after correction for multiple correlation analysis was set at p < 0.023.</p
Kaplan-Meier curve showing survival of patients with IPF according to the levels of SP-B.
No full textKaplan-Meier curve showing survival of patients with IPF according to the levels of SP-B.</p
Serum surfactant protein levels in control subjects according to current smoking habit (current non-smokers N = 16 and current smokers N = 9).
No full textA. SP-A, B. SP-B, C. SP-C, D. SP-D.</p
Serum Levels of Surfactant Proteins in Patients with Combined Pulmonary Fibrosis and Emphysema (CPFE) - Table 2
No full textSerum Levels of Surfactant Proteins in Patients with Combined Pulmonary Fibrosis and Emphysema (CPFE) - Table
Serum Surfactant Protein levels in CPFE patients according to the extent of emphysematous lesions.
No full textSerum Surfactant Protein levels in CPFE patients according to the extent of emphysematous lesions.</p
Flow chart showing subjects who were finally included to the study.
No full textFlow chart showing subjects who were finally included to the study.</p
Serum surfactant protein levels in the different study groups.
No full textA. SP-A, B. SP-B, C. SP-C, D. SP-D.</p
