43,352 research outputs found
DFT and TB study of the geometry of hydrogen adsorbed on graphynes
No full textUsing density-functional calculations (DFT) and a tight-binding model, we investigate the origin of distinct favorable geometries which depend on the type of graphyne used. The change in the H geometry is described in terms of the tuning of the hopping between sp(2)-bonded C atoms and sp-bonded C atoms hybridized with the H atoms. We find that the different preferred geometry for each type of graphyne is associated with the electronic effects due to different symmetries rather than a steric effect minimizing the repulsive interaction between the H atoms. The band gaps are significantly tuned as the hopping varies, except in alpha-graphyne, in agreement with the result of our previous DFT study (Koo J et al 2013 J. Phys. Chem. C 117 11960). Our model can be used to describe the geometry and electronic properties of hydrogenated graphynes
Vibration and Aeroelastic Characteristics of advanced Aircrafts in Transonic and Supersonic Region
No full textThis work was supported through funding from the
Korea Ministry of Science and Technology and Korea
Aerospace Industry (KAI). The authors acknowledge the support as the National Research Laboratory
Program and KAI
Computational Analysis of Fluid/Structure Interaction for Flight Vehicle Structures
No full textThis research was supported by the Korea Aerospace Industries, Ltd., the National Research Laboratory Program from the Korea Ministry of Science and Technology, Agency for Defense Development, and Korea Aerospace Research Institute. The authors thank for their supports
Electric inductance sensor-based path recognition for the highly configurable path tracking of service robot
No full textChemoselective, Isomerization-Free Synthesis of N-Acylketimines from N?H Imines
No full textN-Acylketimines were synthesized through a ruthenium-catalyzed generation of N?H ketimines from secondary azides and subsequent acylation with mixed anhydrides under mild conditions. The synthetic scope was broad to give N-acylimines having various functional groups, including those with aliphatic groups that are prone to tautomerization to the corresponding enamides. In addition, various acyl moieties were accommodated. The synthetic utility of this chemoselective imine generation was illustrated by a highly diastereoselective nucleophilic addition of a Grignard reagent to a cyclic N-acylimine. (Figure presented.). ? 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim111Nsciescopu
S. H. Yoon, J. Y. Han, J. Woo, Y. S. Cho, S.-K. Kwon, Y. C. Bae, D. Kim, E. Kim, M.-H. Kim
No full textMetabolic diseases affect various organs including the brain. Accumulation or depletion of substrates frequently leads to brain injury and dysfunction. Deficiency of aminopeptidase P1, a cytosolic proline-specific peptidase encoded by the Xpnpep1 gene, causes an inborn error of metabolism (IEM) characterized by peptiduria in humans. We previously reported that knockout of aminopeptidase P1 in mice causes neurodevelopmental disorders and peptiduria. However, little is known about the pathophysiological role of aminopeptidase P1 in the brain. Here, we show that loss of aminopeptidase P1 causes behavioral and neurological deficits in mice. Mice deficient in aminopeptidase P1 (Xpnpep1-/- ) display abnormally enhanced locomotor activities in both the home cage and open-field box. The aminopeptidase P1 deficiency in mice also resulted in severe impairments in novel-object recognition, the Morris water maze task, and contextual, but not cued, fear memory. These behavioral dysfunctions were accompanied by epileptiform electroencephalogram activity and neurodegeneration in the hippocampus. However, mice with a heterozygous mutation for aminopeptidase P1 (Xpnpep1+/- ) exhibited normal behaviors and brain structure. These results suggest that loss of aminopeptidase P1 leads to behavioral, cognitive and neurological deficits. This study may provide insight into new pathogenic mechanisms for brain dysfunction related to IEMs. © 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society11sciescopu
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