239,961 research outputs found
On the Erdős-Pósa property for long holes in C_4-free graphs
No full textWe prove that there exists a function f(k)=O(k^2logk) such that for every C4-free graph G and every k∈N, G either contains k vertex-disjoint holes of length at least 6, or a set X of at most f(k) vertices such that G−X has no hole of length at least 6. This answers a question of Kim and Kwon [Erdős-Pósa property of chordless cycles and its applications. JCTB 2020
SYNTHESIS OF D-GALACTOPYRANOSYL-1,2,6-TRISPHOSPHATES AS A GEOMETRIC ANALOGUE OF D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE
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Naratettix cheondungsanus Hossain & Kwon & Suh & Kwon 2019, sp. nov.
No full textNaratettix cheondungsanus sp. nov. (Figs. 1–11) Description. General coloration whitish yellow with patchy orange patterns on crown, pronotum and scutellum. Coronal suture not distinctly visible, with 2 orange spots between posterior margin of crown and anterior margin of pronotum. Face shiny, without conspicuous spots or streaks; rostrum orange. Eye dark brown. Pronotum with two longitudinal orange stripes, and irregular orange patterns on lateral margins. Scutellum with two irregular orange stripes; scutellar suture prominent. Forewing without brown or castaneous band and orange stripe like other species of this group, but two small dark brown spots on 2nd and 4th apical cells. Hindwing hyaline. Leg and body venter whitish yellow. Second sternal apodeme in male with posterior lobes small, round apically, extended up to middle of 3rd sternite. Male genitalia. Pygofer lobe elongate, broad basally, roundly convex at posterior margin with pointed and slanting downwards posterior angle, numerous setae on near to ventrocaudal surface. Subgenital plate with 4 long macrosetae and row of short rigid setae at upper margin subbasally. Style long with narrow base, with prominent preapical lobe, widened and pointed apex. Connective Y-shaped, short base, with long narrow branches diverging on wide arc. Aedeagal shaft straight, long and tubular, strongly bent laterad with two apices in lateral view; dorsal apodeme short, moderately expanded, with pair of process arising from basolateral part of shaft, subapically bent recurringly; gonopore apical. Length. Males 2.6−2.9 mm, females 2.6−2.9 mm. Type material. Holotype male, Korea, Chungbuk Province: Mt. Cheondeungsan, on Quercus sp., 1.X.2016, Y.J. Kwon; Paratypes, 2 males and 3 females, same data as holotype. Distribution. Korea (Central). Host plant. Quercus sp. Etymology. The specific name is derived from name of the mountain of type locality. Remarks. This species differs from other species in lacking a castaneous brown or orange stripe on the forewing. Its male genitalia are similar to Naratettix ibukisianus but differ from the latter by the characteristic tip of the aedeagal shaft and position of the basolateral process.Published as part of Hossain, Md. Shamim, Kwon, Jin Hyung, Suh, Sang Jae & Kwon, Yong Jung, 2019, Taxonomic revision of the microleafhopper genus Naratettix Matsumura (Homoptera: Cicadellidae: Typhlocybinae) from Korea, pp. 148-158 in Zootaxa 4657 (1) on page 149, DOI: 10.11646/zootaxa.4657.1.6, http://zenodo.org/record/337102
Macrosteles nabiae Kwon, sp. nov.
No full text<i>Macrosteles nabiae</i> Kwon, sp. nov. <p>(Plate 3, figs. 10–19)</p> <p> <b>Length (including tegmen).</b> Male: 3.0– 3.4 mm; female: 3.5–4.0 mm.</p> <p>Pale yellow; head with 3 pairs of black spots, not merged; a short black longitudinal band between ocelli and eyes. Ocelli red and large, 0.5 times own diameter from corresponding eye.</p> <p>Male abdomen. 2nd acrotergite with trunk comparatively small and near horizontal, comparatively small, lateral processes usually longer than trunk width; neck very slender, about as long as trunk width. 2nd tergal apodeme reaching near 2/3 of tergite posteriorly. 1st sternal apodeme with posterior lobes slightly longer than wide. 2nd sternal apodeme with posterior lobes about 1.5 times as long as basal width.</p> <p>Male genitalia. Aedeagus with long apical appendages, nearly parallel, strongly curved dorsad in ventral view.</p> <p> <b>Holotype:</b> Korea, Daegu, 13.vii. 1984, Coll. Y.J. Kwon (KPNU). Paratype: 4 males, 10 females, same data as holotype; 1 male, same locality, 8.x.1984, Coll. Y.J. Kwon (KPNU); 2 males, same locality, 10.x.1984, Coll. Y.J. Kwon (KPNU); 1 male, Japan, Kyushu, Fukuoka, Tajima, 29.v.1958, Coll. Y. Miyatake (BMNH); CHINA: 1 male, 2 females, <b>Shanxi Prov.</b>, Jiaocheng County, Pangquangou Township, 26.vii.2006, Coll. Yang Zhaofu; 1 male, <b>Heilongjiang Prov.</b>, Mt. Mi, Peide County, 100m, 2.ix.2001, Coll. Sun Qiang; 2 males, 4 females, <b>Shandong Prov.</b>, Yantai City, Mt. Kunyu, 11.vii.2001, Coll. Qin Daozheng & Liu Zhenjiang; 2 males, 3 females, <b>Shaanxi Prov.</b>, Yangling County, vi.1986, Coll. Zhang Yalin; 1 male, <b>Xinjiang Autonomous Region</b>, Zhaosu City, Mohe Landscape, 30.vii.2006, Coll. Kang Juxia; 9 males, 20 females, <b>Xinjiang Autonomous Region</b>, 187 Corps, 7.viii.2002, Coll. Huang Min (NWAFU).</p> <p> <b>Distribution.</b> China, Korea and Japan.</p> <p> <b>Remarks.</b> This species has been confused with <i>M. laevis</i>, but can be differentiated from the latter by the characters of the male abdomen: 2nd acrotergite with trunk horizontal and 2nd tergal apodemes with posterior lobes not extending beyond posterior margin of tergite.</p> <p> <b>Etymology.</b> The specific epithet “ <i>nabi</i> ” is derived from the name of Dr. Kwon’s daughter, Nabi.</p>Published as part of <i>Yalin, Zhang, Lin, Lu & Kwon, Yong Jung, 2013, Review of the Leafhopper Genus Macrosteles Fieber (Hemiptera: Cicadellidae: Deltocephalinae) from China, pp. 361-392 in Zootaxa 3700 (3)</i> on page 373, DOI: 10.11646/zootaxa.3700.3.3, <a href="http://zenodo.org/record/248993">http://zenodo.org/record/248993</a>
Performance of optical burst switching in time division multiplexed wavelength-routing networks
No full textIn this paper, we propose an optical burst switching architecture in time division multiplexed wavelength-routing networks, in which an edge OBS node requests time slots necessary to optical bursts to the time division multiplexed wavelength-routing network. Our scheme is attempt to improve the burst contention resolution and optical channel utilization
Limassolla koreana Hossain & Kwon & Suh & Kwon 2019, sp. nov.
No full text<i>Limassolla koreana</i> sp. nov. <p>(Figs. 12 ‾23, 47‾50)</p> <p> <b>Description.</b> Body slender, general coloration milky white to yellowish white, mottled with conspicuous orange to yellowish orange patches on crown, pronotum, scutellum and forewing. Crown subtriangularly produced anterad, with two yellowish white stripes on anterior margin, and prominent stripe along midline. Face shiny, pale yellow to whitish, without any spot or streak; rostrum orange, with dark brown apex. Pronotum and scutellum with irregular whitish stripes; scutellum with dark brown spot near apex, with big triangular white stripe, two distinct whitish longitudinal patches at posterior corners. Forewing subhyaline, with orange to yellowish orange patterns, and several black to dark brown spots on costal margin. Hindwing subhyaline. Venter and legs concolorous, whitish. Second sternal apodeme with posterior lobes large, parallel sided, ovoid at apex, reaching to hind margin of 5th sternite.</p> <p> <b>Male genitalia.</b> Pygofer with apical margin dorso-caudad; dorsal margin slightly concave; ventral margin armed with long slender process, arising from caudoventral side, directed dorsally, gently tapered apically. Subgenital plate short and broad, with small apical part, with 2 macrosetae subbasally. Aedeagal shaft almost straight, narrowing terminally, armed with 3 apical slender processes, comprising terminal one directing apically, and two subterminal ones directing basally; gonopore subapical on ventral surface. Style long, slightly curved, with several microsetae medially; apex with sharp angled edge subapically. Connective Y-shaped, with small central lobe.</p> <p> <b>Body length.</b> Male 2.8‾ 3.1mm, female 3.0‾ 3.3mm.</p> <p> <b>Type material.</b> Holotype male, Korea: Chungbuk Province, Jincheon, on <i>Diospyros kaki</i>, 14.VIII.2008, Y.J. Kwon; Paratypes, 8 males & 14 females, same data as holotype; Gyeonggi Province: 2 males, Camp Humphreys, 23. VI.2016, H.C. Kim; Jeonnam Province: 9 males & 6 females, Illimsan, on <i>Diospyros kaki</i>, 23.VIII.2018, Y.J. Kwon.</p> <p> <b>Distribution.</b> Korea (South, Central).</p> <p> <b>Host plant.</b> <i>Diospyros kaki</i> (Persimmon).</p> <p> <b>Remarks.</b> This species is similar to <i>L. kakii</i> Chou et Ma, 1981, but differs in having the aedeagus shaft with 3 apical processes. The new species is the second one known to dwell on persimmon trees in Asia, and it is considered as an occasional pest with sporadic occurrence in Korea so far.</p>Published as part of <i>Hossain, Md. Shamim, Kwon, Jin Hyung, Suh, Sang Jae & Kwon, Yong Jung, 2019, Taxonomic revision of the microleafhopper genus Limassolla Dlabola from Korea (Hemiptrea: Cicadellidae: Typhlocybinae), pp. 549-558 in Zootaxa 4603 (3)</i> on page 552, DOI: 10.11646/zootaxa.4603.3.7, <a href="http://zenodo.org/record/2702383">http://zenodo.org/record/2702383</a>
SO MEE KWON
No full text학위논문(박사)--아주대학교 일반대학원 :의학계열,2014. 2TABLE OF CONTENTS
ABSTRACT i
TABLE OF CONTENTS iii
LIST OF FIGURES v
LIST OF TABLES vi
ABBREVIATIONS vii
I. INTORDUCTION 1
A. Background of study 1
B. Cancer genomic study of HCC 3
C. Aims of study 7
II. MATERIALS AND METHODS 10
A. MATERIALS 10
1. Cell-lines 10
2. Human tissues and FFPE samples 10
3. Preparation of RNA and genomic DNA 10
B. METHODS 11
1. Comparative genomic hybridization (CGH) profiling 11
2. Data pre-processing 12
3. DNA copy number profiling based on the T-statistic map (TM) 13
4. cDNA Microarray profiling 14
5. Determination of DNA copy number-dependent transcriptional deregulation 14
6. Validation of the prognostic relevance in the independent data set 15
7. Estimation of genomic DNA copy number by quantitative PCR (qPCR) 16
8. Gene set enrichment analysis 17
9. Short hairpin RNA (shRNA)-mediated knock-down experiment 17
10. Estimation of mRNA expression level using quantitative PCR (qPCR) 20
11. Cell viability and proliferation assay 21
12. Cell invasion assay 22
13. Western Blot analysis 22
14. Statistical analysis 23
III. RESULTS 25
A. Identification of subtype-specific DNA copy number alteration 25
B. Region of Interest at 6p showed subtype-specific DNA copy number alteration and concomitant transcriptional deregulation 32
C. IER3 is a putative biomarker for the ROI at 6p amplicon 33
IV. DISCUSSION 70
V. CONCLUSION 78
VI. REFERENCES 79
국문 요약 91DoctoralIn recent years, cancer heterogeneity, which is essentially inherent in various types of cancer, has been of interest to the cancer genome research. Many studies using various approaches have tried to solve the conundrum of so-called cancer heterogeneity. However, even though many successes have been earned in this area using the genomic analysis, the identification of precise cancer subtypes, which can be informative and useful from the biological and clinical point of view, still remains a challenge. Among the many trials, the multi-layered genomic profiles analysis, in which the genomic copy numbers and gene expression profiles are analyzed by the integrative way to define the chromosomal regions with both genomic copy number variation and concomitant transcriptional deregulation, is posited to provide a promising strategy to identify driver targets. Here, the integrative analysis of the DNA copy numbers and gene expression profiles of hepatocellular carcinoma (HCC) was performed. By comparing DNA copy numbers in HCC subtypes, which have been previously defined based on gene expression pattern, it was found that the HCC subtype showing aggressive phenotype without expressing stemness-related genes had DNA copy number alteration with concordant gene expression changes in the specific chromosomal area at 6p21-24. Among the genes residing at 6p21-24, IER3 was identified as a potential driver. The clinical utility of IER3 copy numbers was demonstrated by validating its clinical correlation in the independent cohorts. In addition, short hairpin RNA-mediated knock-down experiment revealed the functional relevance of IER3 in liver cancer progression. In conclusion, the results of this study suggest that genomic copy number alterations with transcriptional deregulation at 6p21-24 identify an aggressive HCC phenotype and a novel functional biomarker
Scaphomonus naejangsanus Dutta & Kwon & Suh & Kwon 2020, sp. nov.
No full text<i>Scaphomonus naejangsanus</i> sp. nov. <p>(Figs. 1–12)</p> <p> <b>Description.</b> Genearal coloration ochraceous, with reddish bands. Head with thin arcuate and piceous submargial band anteriorly, with transverse arcuate band between eyes, narrowly margined with piceous, orange red patch. Face with thin arcuate and piceous submarginal band. Pronotum with anterior orange and posterior submarginal brown transverse bands. Forewings ochraceous, with hyaline spots and piceous areas. Head including eyes slightly narrower than pronotum. Crown triangularly produced, distinctly longer medially than next to eyes, 0.8 times as long as width between eyes. Ocelli situated on anterior margin of crown, separated from eye by distance equal to its own diameter. Frontoclypeus narrow, nearly 1.6 times longer than width between antennal pits; transclypeal suture distinct. Anteclypeus slightly expanded apically, with apex following normal curve of genae. Lora almost as wide as anteclypeus basally. Pronotum approximately 1.4 times as long as crown; lateral margin carinate; anterior margin roundly produced; posterior margin slightly concave. Scutellum nearly as long as pronotum, with transverse suture slightly curved and prominent.</p> <p>Second sternal apodeme in male with posterior lobes long and well developed, convergent distally, reaching 4th sternite.</p> <p> <b>Male genitalia.</b> Pygofer slightly longer than wide in lateral view, apparently extended beyond apex of subgenital plates, with numerous long macrosetae in distal half; hind margin subobliquely rounded. Subgenital plates strongly tapering in apical 1/3 to narrowly rounded apex, with a lateral row of stout macrosetae and additional hair like setae. Styles approximately 2.7 times as long as wide basally; preapical lobe prominent, with setose hairs; apophysis gently tapered to narrowly rounded apex. Connective Y-shaped, with arms nearly twice longer than stem, produced lobe-likely on dorsal side in lateral view. Aedeagal shaft slender, wider at base, nearly twice longer than connective, pointed apically, gently curved at distal 1/ 3 in lateral view; gonopore subapical, on dorsal side.</p> <p> <b>Female genitalia.</b> Posterior margin of abdominal sternum VII deeply concave, with dark patch and slender triangular projection medially.</p> <p> <b>Body length.</b> Male 4.6-4.7mm; female 4.9-5.0mm.</p> <p> <b>Type material.</b> Holotype, male, Korea, Jeonbuk Province, Naejangsan, 14.VIII.1981, coll. Y.J. Kwon. Paratypes: 1 female, same data as holotype; 1 female, Gyeongbuk Province, Palgongsan, 23.IX.1984; 1 female, Gyeonggi Province, Gwangneung, 12.VIII.1994, all same collector.</p> <p> <b>Host plant.</b> Unknown.</p> <p> <b>Etymology.</b> The name of the species is derived from the locality of the holotype.</p> <p> <b>Remarks.</b> This new species resembles <i>Scaphomonus indicus</i> (Distant) but can be readily differentiated from the latter by the shape of the subgenital plates and aedeagal shaft.</p>Published as part of <i>Dutta, Nirmal Kumar, Kwon, Jin Hyung, Suh, Sang Jae & Kwon, Yong Jung, 2020, First record of the leafhopper genus Scaphomonus Viraktamath from Korea, with description of one new species (Hemiptera: Cicadellidae: Deltocephalinae), pp. 191-195 in Zootaxa 4747 (1)</i> on page 194, DOI: 10.11646/zootaxa.4747.1.9, <a href="http://zenodo.org/record/3693539">http://zenodo.org/record/3693539</a>
Hacia un sistema de detección automá - tica de talento deportivo: una aplicación al Tae Kwon Do
No full textEl Tae Kwon Do es un arte marcial coreano reconocido como deporte olímpico, para el cual se han desarrollado
diferentes herramientas desde la ingeniería, principalmente enfocadas en mejorar la capacidad de los competidores. Sin embargo, existe una brecha en el proceso de selección de atletas de
alto rendimiento. Por ello, está investigación se enfocó en desarrollar un sistema basado en la información de la clasificación
de los deportistas de la Federación Ecuatoriana de Tae Kwon
Do, utilizando los métodos wrapper y embedded y los algoritmos Decision Tree y Support Vector Machine para la valoración
de los diferentes factores considerados en dicha clasificación. La
principal contribución de este trabajo es proporcionar un sistema de apoyo objetivo para la selección de dichos atletas.Tae Kwon Do is a Korean martial art included as an Olympic sport, where several tools have been deve
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loped from the engineering point of view,mainly focused on improving the capacity of the athletes. Nevertheless, there is
a breach in the selection process of high performance athletes. For this reason, this research was focused on developing
a system based on the information of the classification for the athletes in the Tae Kwon Do Ecuadorian Federation by
using the wrapper and embedded modes and the Decision Tree and Support Vector Machines machine learning algo
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rithms. These algorithms and modes were used to assess the different factors considered in this classification. The main
contribution of this work is to provide a support system for the selection of these athletes
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