1,721,048 research outputs found
Marangoni convection of a viscous fluid over a vibrating plate
No full textThis research presents a new insight into Marangoni convection through investigating, both numerically and analytically, the surface tension driven instability activated by a coupled effect of a vibrating plate and viscous dissipation. A horizontal, thin fluid layer is bounded from below by an impermeable, adiabatic plate that vibrates in the horizontal direction. The upper boundary is modelled by a free surface subject to a thermal boundary condition of the third kind (Robin). The internal heat generation due to viscous dissipation yields a vertical, potentially unstable temperature gradient. The linear stability analysis of the stationary terms of the basic state is performed. The perturbed flow, in the form of plane waves, is superimposed onto the basic state. The obtained system of ordinary differential equations is solved numerically by means of the Runge-Kutta method coupled with the shooting method. For the two limiting cases, the isothermal upper boundary and adiabatic upper boundary, the analytical solutions of the eigenvalue problem are obtained. The values of the critical parameter, which identifies the threshold for the onset of Marangoni convection, are presented
Knowledge and behavior in relation to HIV/STI in Students: Results of a pilot study at the University of Munich
No full textKuznetsov A, V, Kouznetsov L, Zippel SA, Ruzicka T, Krämer A. Knowledge and behavior in relation to HIV/STI in Students: Results of a pilot study at the University of Munich. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT. 2009;7:169-170
Drug Release in Biological Tissues, Chapter 3
No full textProblems involving the release of a drug from a polymeric gel matrix into biological tissues
arise in a number of scientific and bioengineering disciplines. Important technological areas
include drug-eluting stents for the prevention of restenosis [1–6], therapeutic contact lenses
to increase the ocular bioavailability of ophthalmic drugs [7,8] and dermal and transdermal
drug delivery [9–11]
Transdermal Drug Delivery and Percutaneous Absorption: Mathematical Modeling Perspectives, Chapter 10
No full textSystemic delivery of drugs by percutaneous permeation (transdermal drug delivery, TDD)
offers several advantages compared to oral release or hypodermic injection. Because TDD’s
controlled release rate can provide a constant concentration for a long period of time and
improved patient compliance, TDD has been shown to be an attractive alternative to oral
administration [1]. The most advanced delivery systems (electroporation and cavitational
ultrasound) enhance transdermal delivery through a strong and reversible disruption of
the stratum corneum (SC), without damaging the deeper tissues
HIV/STI - Prevalence of knowledge, Sexual behaviour and Condom use among German students and among Students from the Commonwealth of Independent States (CIS)
No full textKuznetsov A, V, Kouznetsov L, Ruzicka T, Krämer A. HIV/STI - Prevalence of knowledge, Sexual behaviour and Condom use among German students and among Students from the Commonwealth of Independent States (CIS). JDDG Journal der Deutschen Dermatologischen Gesellschaft. 2011;9:151-151
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Model of drug delivery to populations composed of two cell types
No full textThe rate of drug delivery to cells and the subsequent rate of drug metabolism are dependent on the cell membrane permeability to the drug. In some cases, tissue may be composed of different types of cells that exhibit order of magnitude differences in their membrane permeabilities. This paper presents a brief review of the components of the tissue scale three-compartment pharmacokinetic model of drug delivery to single–cell–type populations. The existing model is extended to consider tissue composed of two different cell types. A case study is presented of infusion mediated delivery of doxorubicin to a tumor that is composed of a drug reactive cell type and of a drug resistive cell type. The membrane permeabilities of the two cell types differ by an order of magnitude. A parametric investigation of the population composition is conducted and it is shown that the drug metabolism of the low permeability cells are negatively influenced by the fraction of the tissue composed of the permeable drug reactive cells. This is because when the population is composed mostly of drug permeable cells, the extracellular space is rapidly depleted of the drug. This has two compounding effects: (i) locally there is simply less drug available to the neighboring drug resistant cells, and (ii) the depletion of the drug from the extracellular space near the vessel-tissue interface leaves less drug to be transported to both cell types farther away from the vessel
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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