324,547 research outputs found
Better Reporting of Intraoperative Adverse Events with focus on abdominal surgery
No full textContains fulltext :
305545.pdf (Publisher’s version ) (Open Access)Radboud University, 23 mei 2024Promotor : Goor, H. van Co-promotores : Dell-Kuster, S., Broek, R.P.G ten234 p
MAKING PUPPETS AS A STIMULATION FOR PREPARING A SHOW IN KINDERGARTEN
No full textZaključno delo z naslovom Izdelava lutk kot spodbuda za pripravo predstave v vrtcu je sestavljeno iz teoretičnega in praktičnega dela.
V teoretičnem delu smo predstavili različne vrste lutk in simbolno igro, kajti pri otrocih poteka vse preko igre. Na podlagi strokovne literature smo opisali vpliv lutke na otroka in opredelili simbolno igro v vrtcu.
Praktični del smo izvajali v vrtcu, v drugem starostnem obdobju. Zasnovan je bil iz priprav, katerih cilj je bil spodbuditi otroke k samostojni lutkovni predstavi. Naš namen je bil otrokom predstaviti različne tehnike lutk in jih pripraviti do spontane igre z njimi. Otroci so lutke spoznali, se z njimi naučili rokovati, sami so si izmislili zgodbico in pripravili vse potrebno za lutkovno predstavo. Na koncu so otroci uprizorili lutkovno predstavo, katere vir je bila otrokova domišljija.The final thesis entitled Making puppets as a stimulation for preparing a show in kindergarten consists of a theoretical and a practical part.
In the theoretical part, we presented different types of puppets and symbolic playsince children learn through play. Based on scientific literature, we described the influence of the puppet on the child and defined symbolic game in kindergarten.
The practical part was carried out in kindergarten, in the second age group. It was designed from the preparations of which the goal was to encourage children to stage an independent puppet show. Our intention was to introduce the various puppet techniques and encourage children to play with the puppets spontaneously. Children became familiar with the puppets and have learned how to use them, they invented a story and prepared everything necessary for the puppet show. At the end, children staged the puppet show, the source of which was a child\u27s imagination
The Rokitansky-Kuster-Hauser syndrome with chromosome XO/XX mosaicism (single pelvic kidney)
No full textA case of Rokitansky-Kuster-Hauser syndrome and Turner syndrome association is reported. Alongside vaginal aplasia and rudimentary uterus (typical of Rokitansky-Kuster-Hauser), the patient in fact presented XX/XO type chromosome mosaicism with 20% positivity of sexual chromatin. The rarity of the association between phenotypical features identifying Rokitansky-Kuster-Hauser syndrome and gross genetic changes suggested that the case deserved reporting. A depth urological diagnosis also pointed to the existence of a large solitary pelvic kidney
Decreasing of COD in wastewater with Fenton\u27s reagent
No full textCilj magistrske naloge je bil ugotoviti, ali je z uporabo Fentonovega reagenta mogoče znižati onesnaženost odpadne vode z organskimi spojinami, izraženo s kemijsko potrebo po kisiku (KPK). Fentonov reagent pomeni reakcijo med železovimi ioni Fe2+ in vodikovim peroksidom, pri čemer nastanejo visoko reaktivni hidroksilni radikali, ki razgrajujejo organske spojine.
Pripravili smo sintetične vzorce odpadne vode s huminsko kislino in tioureo. V nadaljevanju smo čistili tudi realno kompostno izcedno vodo. Eksperimente smo izvajali pri različnih pogojih Fentonove reakcije, tako da smo spreminjali maso FeSO4 × 7H2O, ki smo ga uporabili kot vir Fe2+, razmerje med reagenti, čas trajanja reakcije in pH-vrednost. Učinek čiščenja smo v glavnem spremljali z merjenjem KPK, absorbance in motnosti.
Ugotovili smo, da je bila Fentonova reakcija primerna za čiščenje sintetičnih vzorcev odpadne vode s huminsko kislino in kompostne izcedne vode, medtem ko za sintetične vzorce odpadne vode s tioureo znižanja KPK nismo dosegli. Najbolj učinkovito znižanje KPK je pri obdelavi sintetične odpadne vode s huminsko kislino znašalo 97,40 %, dosegli pa smo ga pri pogojih reakcije: "mFeSO4 × 7H2O " = 0,2 g, "nFeSO4 × 7H2O∶ nH2O2 " = 1 : 3, pH = 3, t = 60 min. Najučinkovitejše znižanje KPK pri obdelavi kompostne izcedne vode je doseglo 64,08 % pri pogojih reakcije: "mFeSO4 × 7H2O " = 0,6 g, "nFeSO4 × 7H2O∶ nH2O2 " = 1 : 5, pH = 4,5, t = 30 min.The aim of the master thesis was to determine whether the use of Fenton\u27s reagent can reduce pollution of wastewater with organic compounds, expressed as the chemical oxygen demand (COD). Fenton\u27s reagent means the reaction between iron ions Fe2+ and hydrogen peroxide, whereby highly reactive hydroxyl radicals, which decompose organic compounds are formed.
We prepared synthetic wastewater samples containing humic acid and thiourea. Hereinafter, we also cleaned a real compost leachate. Experiments were carried out under different conditions of Fenton\u27s reaction by varying the ratio of the reagents, the reaction time, the pH value and the mass of FeSO4 × 7H2O, which was used as a source of Fe2+. The cleaning efficiency was mainly monitored by measuring COD, absorbance and turbidity.
We have found that Fenton\u27s reaction was suitable for treatment of synthetic wastewater containing humic acid and for treatment of compost leachate, while in the case of synthetic wastewater containing thiourea COD reduction was not achieved. The maximum reduction of COD for the treatment of wastewater containing humic acid stood at 97.40%, achieved at following conditions: "mFeSO4 × 7H2O " = 0,2 g, "nFeSO4 × 7H2O∶ nH2O2 " = 1 : 3, pH = 3, t = 60 min. The maximum reduction of COD for the treatment of compost leachate has reached 64.08 % at the reaction conditions: "mFeSO4 × 7H2O " = 0,6 g, "nFeSO4 × 7H2O∶ nH2O2 " = 1 : 5, pH = 4,5, t = 30 min
SHOX duplications found in some cases with type I Mayer-Rokitansky-Kuster-Hauser syndrome
No full textPurpose: The Mayer-Rokitansky-Kuster-Hauser syndrome is defined as congenital aplasia of mullerian ducts derived structures in females with a normal female chromosomal and gonadal sex. Most cases with Mayer-Rokitansky-Kuster-Hauser syndrome are sporadic, although familial cases have been reported. The genetic basis of Mayer-Rokitansky-Kuster-Hauser syndrome is largely unknown and seems heterogeneous, and a small number of cases were found to have mutations in the WNT4 gene. The aim of this study was to identify possible recurrent submicroscopic imbalances in a cohort of familial and sporadic cases with Mayer-Rokitansky-Kuster-Hauser syndrome. Methods: Multiplex ligation-dependent probe amplification was used to screen the subtelomeric sequences of all chromosomes in 30 patients with Mayer-Rokitansky-Kuster-Hauser syndrome (sporadic, n = 27 and familial, n = 3). Segregation analysis and pyrosequencing were applied to validate the MLPA results in the informative family. Results: Partial duplication of the Xpter pseudoautosomal region 1 containing the short stature homeobox (SHOX) gene was detected in five patients with Mayer-Rokitansky-Kuster-Hauser syndrome (familial, n = 3 and sporadic, n = 2) and not in 53 healthy controls. The duplications were not overlapping, and SHOX was never entirely duplicated. Haplotyping in the informative family revealed that SHOX gene duplication was inherited from the unaffected father and was absent in two healthy sisters. Conclusions: Partial duplication of SHOX gene is found in some cases with both familial and sporadic Mayer-Rokitansky-Kuster-Hauser type I syndrome
THE INFLUENCE OF INTERMOLECULAR VAN DER WAALS FORCES ON THE FORMATION OF ASSOCIATED MOLECULES
No full textNamen diplomske naloge je preučiti vpliv van der Waalsovih sil na tvorbo asociiranih molekul. V ta namen smo izbrali površinsko aktivne snovi, ki imajo amfifilne lastnosti in vplivajo na povšinske in medfazne napetosti ter pri določeni koncentraciji, imenovani kritična micelna koncentracija (CMC), tvorijo molekulske skupke, ki jim pravimo micele. Kritično micelno koncentracijo smo določili trem površinsko aktivnim snovem: heksadeciltrimetilamonijevemu bromidu, tetradeciltrimetilamonijevemu bromidu in n dodeciltrimetilamonijevemu bromidu. Eksperimente smo izvajali pri temperaturah 25 °C, 30 °C in 35 °C s klasično konduktometrično metodo. Na osnovi rezultatov smo analizirali vpliv van der Waalsovih sil na proces asociacije molekul v micele.
Za izbrano temperaturno območje smo ugotovili, da vrednosti kritične micelne koncentracije rastejo s povišanjem temperature in da se z višanjem števila C atomov v molekuli površinsko aktivne snovi kritične micelne koncentracije znižujejo. Po izračunu stopnje ionizacije micele α, stopnje vezave protiiona β in standardne Gibbsove proste energije pri micelizaciji 〖∆G〗_mic^°, smo ugotovili, da so vrednosti standardne Gibbsove proste energije pri micelizaciji v vseh primerih negativne in s podaljševanjem alkilne verige v molekuli padajo, kar si razlagamo kot krepitev privlačnih van der Waalsovih sil, ki posledično povzročijo nastanek micele pri nižji vrednosti kritične micelne koncentracije.The aim of the diploma thesis was to investigate the influence of van der Waals forces on formation of the associated molecules. For this purpose we chose surface active agents, which have amphiphilic properties and they affect on surface and interface tensions and on the certain concentration, called critical micelle concentration (CMC), they form molecular assemblies, known as micelles. We determined critical micelle concentration to three surfactants: hexadecyltrimethylammonium bromide, tetradecyltrimethylammonium bromide and n-dodecyltrimethylammonium bromide. We executed the experiment at temperatures 25 °C, 30 °C and 35 °C with clasic conductometry method. On the basis of the results, we analysed the influence of van der Waals forces on the process of association of molecules to micelles.
For chosen temperature range, we found out, that values of critical micelle concentration increase with increasing temperature and with the extension of the number of C atoms in molecule of surfactant critical micelle concentration decreases. According to calculation of ionization degree α, degree of binding counterion β and standard Gibbs energy of micellization 〖∆G〗_mic^°, we found out, that values of standard Gibbs energy of micellization are in all cases negative and with extending alkyl chain in molecule, decrease, what we explain as enhancement of attractive van der Waals forces, which consequentially cause formation of micelle at lower value of critical micelle concentration
Melt pool detection at wire arc welding
No full textPri izdelavi 3D tiskanih kovinskih izdelkov s postopkom obločnega navarjanja z žico je težko doseči dobro dimenzijsko natančnost zaradi nestacionarnosti varilnega postopka, kar se odraža v valovitosti sten izdelkov in razliki med željeno in dejansko višino navarjenega sloja. Napaka se povečuje z večanjem števila navarjenih slojev. Z namenom povečanja dimenzijske natančnosti postopka smo razvili sistem za snemanje varjenja z visokohitrostno kamero ter algoritem za robustno in hitro zaznavo bazena taline iz dobljenih slik. Analizirali smo možnosti uporabe dobljenih podatkov o bazenu taline kot povratno zanko za krmiljenje varilnega aparata.Achieving good dimensional accuracy for 3D printed objects with the Gas metal arc welding process (Wire-arc additive manufacturing) is difficult because of the non-stationarity of the welding process, which results in object wall waviness and differences between the desired and actual layer height of the welded material. This error is cumulative and rises in proportion to the number of welded layers. To improve the dimensional accuracy of Wire-arc additively manufactured objects, we design a system to record welding using a high speed camera, and design an algorithm for robust and fast melt pool detection from the images. We analyze the possibilities of using this data as a feedback loop for controlling the welding machine parameters in real time
Comparison of web application functional test automation frameworks
No full textSpletne aplikacije se s časom izboljšujejo in imajo vse več funkcionalnosti, kar privede do potrebe po avtomatizaciji testiranja. V diplomskem delu so predstavljeni načini testiranja in življenjski krog testiranja, diplomsko delo pa se osredotoča na avtomatsko funkcionalno testiranje. Izmed množice ogrodij za avtomatizacijo funkcionalnih testov smo izbrali tri ogrodja (Katalon Studio, Ranorex Studio in Telerik Test Studio), s katerimi smo testirali spletno stran. Diplomsko delo vsebuje primerjavo ogrodij ter izdelan odločitveni model. Odločitveni model je kazal minimalne razlike v rezultatih, zato smo izdelali še enega, ki se osredotoča na potrebe posameznika.Web applications are getting better and have more functions than ever, which lead to the need for automated testing. In this thesis testing methods and lifecycle of testing are presented, still, the main focus is on automated functional testing. From a set of frameworks for automating functional tests, we chose three (Katalon Studio, Ranorex Studio and Telerik Test Studio) for testing the web application. The thesis contains a comparison of frameworks and made decision support system. Decision support system pointed out minimal difference in results, therefore we made another decision support system, which has the focus on needs of individuals
NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling
No full textModerate levels of reactive oxygen species (ROS) act as mediators in cellular signalling processes. An important source of cardiac ROS is the highly expressed NADPH oxidase (NOX) family isoform NOX2. However, little is known about whether NOX-derived ROS are protective in the heart.
In this study we show that CD29 (β1-integrin), a cell adhesion receptor highly expressed on cardiac muscle cells, induces NOX-dependent ROS. CD29 is known to be mandatory in cell growth and survival, and non-functional CD29 causes severe heart disease. We demonstrate that NOX2-derived ROS are essential for CD29-induced survival signalling, including the PI3K/PKB and MEK/ERK pathways. Furthermore, CD29-induced NOX-derived ROS are indispensible in the inhibition of the pro-apoptotic kinase GSK-3β, which we uncovered as a downstream target of both the ERK and PKB survival pathways in cardiac muscle cells. These findings clearly add to the growing body of evidence suggesting that moderate ROS levels are beneficial to the cell and highlight the crucial role of NOX2-derived ROS for cell survival in the heart
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