694 research outputs found
Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex
No full textCampylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry, livestock, and human disease cases to host-adapted specialized lineages primarily associated with livestock or poultry. Here, we present novel data on the ST403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show that the lineage exhibits a distinctive pattern of intralineage recombination that is accompanied by the presence of lineage-specific restriction-modification systems. Furthermore, we show that the ST403 complex has undergone gene decay at a number of loci. Our data provide a putative link between the lack of association with avian hosts of C. jejuni ST403 and both gene gain and gene loss through nonsense mutations in coding sequences of genes, resulting in pseudogene formation
Chaste/Chaste: Chaste 2024.1
No full textChaste - Cancer Heart And Soft Tissue Environment - main public repository.Joe Pitt-Francis, Gary Mirams, Jonathan Cooper, Fergus Cooper, Dr Maurice Hendrix, Alex Fletcher, jmosborne, Rafel Bordas, MILeach, aydaruatay, Ben Evans, Jochen Kursawe, Twin Karmakharm, Martin Robinson, Kwabena N Amponsah, Thomas Pak, Alberto, Louise Bowler, saradutta, … georgiabeeton. (2024). Chaste/Chaste: Chaste 2024.1 (2024.1). Zenodo. https://doi.org/10.5281/zenodo.1068970
Chaste
No full textChaste - a C++ library for computational physiology and biology simulationsJoe Pitt-Francis, Gary Mirams, Jonathan Cooper, Fergus Cooper, Dr Maurice Hendrix, Alex Fletcher, James Osborne, Rafel Bordas, MILeach, aydaruatay, Ben Evans, Jochen Kursawe, Twin Karmakharm, Kwabena Amponsah, Martin Robinson, Jack, Alberto, Louise Bowler, saradutta, … georgiabeeton. (2024). Chaste (2024.2). Zenodo. https://doi.org/10.5281/zenodo.1394176
Die Römische Republik /
No full textWer sich für antike Geschichte interessiert, greift zu dieser knappen und gut lesbaren Geschichte der Römischen Republik, geschrieben von einem der bekanntesten Althistoriker Deutschlands. Jochen Bleicken (1926-2005) führt den Leser von der Zeit der Etrusker bis zum Ende der Republik, das die Herrschaft Caesars besiegelte. Alle wichtigen Phasen der republikanischen Geschichte entfalten sich: die Ständekämpfe, Aufstieg Roms zur Weltherrschaft - und die zugehörigen ungeheuren kriegerischen Auseinandersetzungen -, Ursachen und Beginn der inneren Krise seit den Gracchen, die Restauration unter Sulla und schließlich: die Auflösung der Republik und die Begründung der Monarchie. Aloys Winterling Jochen Bleicken, 1926-2005, war Professor für Alte Geschichte an der Universität Göttingen und u.a. Mitherausgeber von "Oldenbourg Grundriss der Geschichte" und der HISTORISCHEN ZEITSCHRIFT.Wer sich für antike Geschichte interessiert, greift zu dieser knappen und gut lesbaren Geschichte der Römischen Republik, geschrieben von einem der bekanntesten Althistoriker Deutschlands. Jochen Bleicken (1926-2005) führt den Leser von der Zeit der Etrusker bis zum Ende der Republik, das die Herrschaft Caesars besiegelte. Alle wichtigen Phasen der republikanischen Geschichte entfalten sich: die Ständekämpfe, Aufstieg Roms zur Weltherrschaft - und die zugehörigen ungeheuren kriegerischen Auseinandersetzungen -, Ursachen und Beginn der inneren Krise seit den Gracchen, die Restauration unter Sulla und schließlich: die Auflösung der Republik und die Begründung der Monarchie. Aloys Winterling Jochen Bleicken, 1926-2005, war Professor für Alte Geschichte an der Universität Göttingen und u.a. Mitherausgeber von "Oldenbourg Grundriss der Geschichte" und der HISTORISCHEN ZEITSCHRIFT.Mode of access: Internet via World Wide Web.Description based on online resource; title from PDF title page (publisher's Web site, viewed 08. Jul 2019
Essentials of services marketing / Jochen Wirtz, Christopher Lovelock.
No full textIncludes bibliographical references and indexes.(xxxii, 670 pages) :Essentials of Services Marketing, 3e, is meant for courses directed at undergraduate and polytechnic students, especially those heading for a career in the service sector, whether at the executive or management level. It delivers streamlined coverage of services marketing topics with an exciting global outlook with visual learning aids and clear language. It has been designed so that instructors can make selective use of chapters and cases to teach courses of different lengths and formats in either services marketing or services management
Bayesian inference reveals stochastic amplification of gene expression oscillations during embryonic neurogenesis
No full textThe control and downstream interpretation of gene expression dynamics is crucial in many biological contexts. For example, gene expression oscillations have been proposed to control the timing of cell differentiation during embryonic neurogenesis. However, mathematical analysis of gene expression dynamics may be hindered by sparse data and parameter uncertainty. Here, we combine Bayesian inference and quantitative experimental data on mouse and zebrafish neurogenesis to explore mechanisms controlling aperiodic and oscillatory gene expression dynamics during cell differentiation. We find that quantitatively accurate model predictions are possible despite high parameter uncertainty. We identify examples of stochastic amplification, where oscillations are enhanced by intrinsic noise and we show how such oscillations can be initiated by changes in biophysical parameters. We further consider mechanisms that may enable the down-stream interpretation of dynamic gene expression. Our analysis illustrates how quantitative modelling can help unravel fundamental mechanisms of dynamic gene regulation.Non UBCUnreviewedAuthor affiliation: University of ManchesterPostdoctora
Analysis, interpretation, and the local dimension of economic transformation: What went wrong and why?
No full textTransformation has been put in motion by a variety of both endogenous and exogenous forces. Although not any process was under the control of those countries, their choice of goals and instruments was anyway particularly great, at least theoretically. However, transformation was implemented as a rather narrowly defined and technically circumscribed problem-solving process aiming at applying sound general principles of economics and management to reach well-defined goals. It turned out to generate new problems and resulted in different outcomes in different countries and, within individual countries, in different territories. This paper treats transformation as innovation and considers that it had to deal with different dimensions, including both general principles and local features, opportunities, and constraints, and both analysis based on problem-solving, and interpretation of the new situation. These dimensions should have been managed simultaneously, but failed to do so. The paper provides a general explanation for the failure in managing simultaneously the various components of transformation and considers what the 2008 international crisis has revealed of the implementation of 20 years of transformation.Transformation, Local development, Reform, Analysis, Interpretation, Crisis, Washington Consensus, Innovation
Quantitative approaches to investigating epithelial morphogenesis
No full textMorphogenesis - the generation of biological shape and form - is fascinating, and its study promises to shed light on a wide range of developmental defects and inform strategies for the artificial growth of organs. Recently, the experimental study of morphogenesis has thrived due to a rise in quantitative methods.The resulting avalanche of quantitative data requires us to rethink the scientific method. We need to design quantitative hypotheses through mathematical models, make quantitative experimental predictions, devise methods for quantitative data analysis, and design methods for quantitative inference using models and data. This thesis aims to enable this transition for the integrative analysis of morphogenesis in epithelia, one of the major tissue types in animals. We begin by conducting the first systematic numerical analysis of a widely used cell-based model of epithelia, the vertex model, and estimate to what extent quantitative model predictions may be influenced by parameter values and implementation details. We then apply this model to a key question in developmental biology by constructing a quantitative theory for tissue size control in the embryonic epidermis of the fruit fly Drosophila, using the model to predict the outcomes of future experiments. Subsequently, we devise a method for estimating mechanical parameters of vertex models from imaging data and quantifying the uncertainty associated with such estimates. Finally, we propose a novel algorithm for robust cell tracking in live-imaging microscopy videos of epithelial tissues that illustrates how graph theoretic concepts may be used to overcome challenges in quantitative data analysis. Together, the contributions in this thesis will enable the quantitative study of epithelia for a wide range of applications
Jochen Gerz // Jean Louis Garnell
No full textAlbertini's brief descriptions of Garnell's and Gerz's photo and text based works focus on the temporal and spatial limitations of language and image. Includes short texts by both artists
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