2,421 research outputs found

    Letter from Cy Donner to Michi Weglyn, June 2, 1967

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    A letter from Cy Donner to Michi Weglyn encouraging her to come out to California to talk to producers about two shows called "Youthquake" and "Pretty Talk".These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn

    Kuo-2014-Genetics-Fig3

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    These primary data are summarized and discussed in Kuo et al., Genetics (2014). Data in this file are from the P{wa} assay, first published in Adams et al., Science (2002), DOI: 10.1126/science.1077198 . The first tab has counts of progeny from each vial. As in other uses of this assay, only daughters that did not recieve the transposase chromosome (Cy+) were scored. Since the Df(3R)ED6058 chromosome has w+ on it, only progeny that recieved a Sbchromosome were scored. f red = frequency of red-eyed flies f yellow = frequency of yellow-eyed flies The last tab has molecular analysis of synthesis and/or deletion in the yellow-eyed daughters. Each row represents presence (+) or absence (-) of a PCR product in white-eyed sons of yellow-eyed progeny. Each yellow-eyed progeny came from a different vials (f numbers are Fancm, c numbers are control). Distance of furthers primer from left or right end of the element is indicated. Primers used are listed

    Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia

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    The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria were compared: first time for SCT, aged 15-59 years; first or second complete remission at SCT; bone marrow or peripheral blood as stem cell source; and HLA phenotypically matched donor. Median age of the patients was 34 years, and patients who received VP/CY/TBI were younger (28 years vs. 34 years, P = 0.02). Cumulative incidences of relapse and non-relapse mortality (NRM) were higher for patients who received CY/TBI (P = 0.01 for relapse, P < 0.01 for NRM). After a median follow-up period of 36.9 months, 5-year overall survival (OS) rates were 82.2% in the VP/CY/TBI group and 55.2% in the CY/TBI group. OS, and disease-free survival (DFS) in the VP/CY/TBI group were shown to be significantly better by multivariate analysis [hazard ratio: 0.21 (95% confidence interval: 0.06-0.49) for DFS, hazard ratio: 0.25 (95% confidence interval: 0.08-0.59) for OS]. VP/CY/TBI was associated with a lower relapse rate and no increase in NRM, resulting in better survival than that in CY/TBI for adult ALL patients
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