109 research outputs found
The cemented total hip
No full textCemented total hip replacement is becoming less popular, particularly on the acetabular side. This is in spite of the fact that in most countries with registries the results of cemented hips are outperforming those of cement less hips. The difference is particular profound in older patients and on the femoral rather than the acetabular side. The author contends that a capable orthopedic surgeon should be able to perform a well cemented total hip replacement. There are a number of steps that add 5– 10 minutes to the operation, but these are not technically difficult. In fact, the author maintains that it is easier to perform a cemented total hip replacement than an uncemented total hip replacement. The steps are logical; component positioning is easy and the subsequent revision, if ever required, is a straight forward procedure. In conclusion, the author believes that cemented total hip replacement is an excellent option in all age groups. There is no evidence in the literature in registry series to counteract this assumption. The procedure does stay slightly longer, but the steps are logical and relatively straight forward. The intermediate and long-term results are excellent, and revision of a failed cemented hip is a straightforward procedure
Personal Identity as a Story: An Evaluation of Marya Schechtman's Narrative Self-Constitution View
No full textabstract: Personal identity stands at the heart of many practical practices such as paying individuals for their work or holding people responsible for their actions. As such, it seems important that theories of personal identity are able to account for the practical implications of personal identity. Mindful of the practical importance of personal identity, Marya Schechtman argues that the only accounts of personal identity that can capture this practical importance are those that address the characterization question \u2014 the question of what makes some feature attributable to a person. She then posits her narrative self-constitution view as an account of personal identity she feels answers the characterization question and is capable of explaining the link between personal identity and certain features of persons. In this paper, I argue that her account ultimately does not serve her purposes as it only focuses on attribution of features and does not, in fact, account for personal identity. Given that her view is exclusively about attribution, I explain, it is not relevant to the conversation on personal identity. Upon making this argument, I describe how the narrative self constitution view may nevertheless be useful as a tool for understanding the phenomenological notion of a sense of self or a self conception. Here I argue against Galen Strawson who holds that a narrative self conception is oftentimes problematic and unnecessary for several practical human functions. I argue that having a narrative sense of self is useful for personal growth insofar as it involves placing emphasis on certain life events, placing those events in context, and seeing one's life as having direction. Ultimately, I argue that a narrative self conception is not as problematic as Strawson thinks and may often be a useful tool for self-improvement
The effect of polymer architecture, composition, and molecular weight on the properties of glycopolymer-based non-viral gene delivery systems
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The effect of molecular weight, compositions and lectin type on the properties of hyperbranched glycopolymers as non-viral gene delivery systems
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Synthesis of gold nanorods using short peptide sequences
No full textGold Nanorods have become increasingly explored materials in recent years for their wide
variety of applications, from thermo-sensitive drug carriers, imaging and tumour detection to
density recordings and molecular rulers. Gold nanorods can be synthesized by several different
methods. However, all the reported methods require Cetrimonium bromide (CTAB) as a
stabilizer. CTAB is a cationic surfactant that directs the growth of gold nanorods but is extremely
toxic and largely limits the applications of synthesized nanorods for biomedical purposes.
Recently, peptide-based self assembled materials have received much attraction and research
suggests peptides can self-assemble into diverse morphologies, including nanorods.
Diphenylalanine is one of the most studied peptide sequences that is known to self assemble into
rods, fibers and needles. These peptide based morphologies are affected by various factors, such
as, the pH value, the type of reducing solvents, peptide, and gold concentrations.
In this study, we are focused on synthesizing gold nanorods using self-assembled peptides as a
template. The replacement of CTAB with a bio-compatible peptides as a template should provide
a better strategy to develop non-toxic nanorods with various potential applications for biomedical
purposes
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