77,187 research outputs found
Li han lin quan ji: si shi er juan, mu lu si juan, nian pu. v.1
No full text[李白].綫裝, 1函.框20.3x14.8公分, 9行18字, 小字雙行同. 白口, 左右雙邊, 單白魚尾. 版心中鐫"李集"及卷次, 下鐫葉次.書根印有"李翰林集"前有王樨登序, 李陽冰《李翰林詩序》, 樂史《別集序》, 宋敏求後序, 曾鞏後序, 毛漸題跋.書中樂史《別集序》載"李翰林歌詩李陽冰纂為草堂集十卷史又別收歌詩十卷與草堂集互有得失因校勘排為二十卷號曰李翰林集"With: 李翰林年譜 / 薛仲邕編 ; 舊唐書列傳 ; 新唐書列傳 ; 李翰林墓誌銘 / 李華 ; 碣記 / 劉全 ; 碑陰記 / 蘇軾.Xian zhuang, 1 han.Kuang 20.3 x 14.8 gong fen, 9 hang 18 zi, xiao zi shuang hang tong. Bai kou, zuo you shuang bian, dan bai yu wei. Ban xin zhong juan "Li ji"ji juan ci, xia juan ye ci.Shu gen yin you "Li han lin ji"Qian you Wang Xideng xu, Li Yangbing "Li han lin shi xu", Yue Shi "Bie ji xu", Song Minqiu hou xu, Zeng Gong hou xu, Mao Jian ti ba.Shu zhong Yue Shi "Bie ji xu" zai "Li han lin ge shi Li Yangbing zuan wei Cao tang ji shi juan shi you bie shou ge shi shi juan yu Cao tang ji hu you de shi yin jiao kan pai wei er shi juan hao yue Li han lin ji"[Li Bai].With: Li han lin nian pu / Xue Zhongyong bian ; Jiu Tang shu lie zhuan ; Xin Tang shu lie zhuan ; Li han lin mu zhi ming / Li Hua ; Jie ji / Liu Quan ; Bei yin ji / Su Shi
Han lin shuo chang zhuan ji dai
No full textLive recording.Possibly reproduced from other commercial recording or radio broadcast (Pending for review)Electronic reproduction from Rulan Chao Pian Betamax collection.Performing group: 漢霖民俗說唱藝術團.Sung in Chinese.Performing group: han lin min su shuo chang yi shu tuan
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
No full textGlutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional state modeling, we demonstrate that a kinetic scheme consisting of two sequential and reversible steps of release–machinery assembly and a final step of synaptic vesicle (SV) fusion reproduces STP and its diversity among synapses. Analyzing transmission at the calyx of Held synapses reveals that differences in synaptic strength and STP are not primarily caused by variable fusion probability (p(fusion)) but are determined by the fraction of docked synaptic vesicles equipped with a mature release machinery. Our simulations show that traditional quantal analysis methods do not necessarily report p(fusion) of SVs with a mature release machinery but reflect both p(fusion) and the distribution between mature and immature priming states at rest. Thus, the approach holds promise for a better mechanistic dissection of the roles of presynaptic proteins in the sequence of SV docking, two-step priming, and fusion. It suggests a mechanism for activity-induced redistribution of synaptic efficacy
Presynaptic Ca2+ influx and vesicle exocytosis at the mouse endbulb of Held: A comparison of two auditory nerve terminals.
No full textNon-technical summary The release of neurotransmitter from presynaptic nerve endings is triggered by Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) that open when an action potential (AP) invades the presynaptic terminal. The functional properties of VGCCs expressed in presynaptic terminals remain elusive because most terminals are too small to be accessible to electrophysiological recordings. We performed direct presynaptic recordings to characterize Ca2+ channels and transmitter release in a large mammalian presynaptic terminal, the endbulb of Held. Endbulb terminals are formed by the endings of auditory nerve fibres that contact bushy cells located in the anterior ventral cochlear nucleus. We find that endbulb terminals are endowed with >1000 readily releasable vesicles and express an average number of >6000 VGCCs. About half of the VGCCs open during a single AP. Thus, multiple Ca2+ channels control the release of a single transmitter vesicle at the endbulb of Held
Similar Intracellular Ca2+ Requirements for Inactivation and Facilitation of Voltage-Gated Ca2+ Channels in a Glutamatergic Mammalian Nerve Terminal
No full textVoltage-gated Ca (2+) channels (VGCCs) of the P/Q-type, which are expressed at a majority of mammalian nerve terminals, show two types of Ca (2+)-dependent feedback regulation-inactivation (CDI) and facilitation (CDF). Because of the nonlinear relationship between Ca (2+) influx and transmitter release, CDI and CDF are powerful regulators of synaptic strength. To what extent VGCCs inactivate or facilitate during spike trains depends on the dynamics of free Ca (2+) ([Ca2+](i)) and the Ca2+ sensitivity of CDI and CDF, which has not been determined in nerve terminals. In this report, we took advantage of the large size of a rat auditory glutamatergic synapse-the calyx of Held-and combined voltage-clamp recordings of presynaptic Ca (2+) currents (I-Ca(v)) with UV-light flash-induced Ca (2+) uncaging and presynaptic Ca (2+) imaging to study the Ca (2+) requirements for CDI and CDF. We find that nearly half of the presynaptic VGCCs inactivate during 100 ms voltage steps and require several seconds to recover. This inactivation is caused neither by depletion of Ca (2+) ions from the synaptic cleft nor by metabotropic feedback inhibition, because it is resistant to blockade of metabotropic and ionotropic glutamate receptors. Facilitation of I-Ca(V) induced by repetitive depolarizations or preconditioning voltage steps decays within tens of milliseconds. Since Ca (2+) buffers only weakly affect CDI and CDF, we conclude that the Ca (2+) sensors are closely associated with the channel. CDI and CDF can be induced by intracellular photo release of Ca (2+) resulting in (Ca2+](i); elevations in the low micromolar range, implying a surprisingly high affinity of the Ca (2+) sensors
Dr. Lin Sun, CAU, March 2013
No full textThis video is a conversation with Dr. Lin Sun. Dr. Sun talks about an exhibit at the Woodruff Library titled "At The Boundary." Jordan Moore, AUC Woodruff Library, is the interviewer
Author response image 1.
No full textNeurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential. We combined capacitance measurements and pH-imaging via pH-sensitive vesicular protein marker (anti-synaptotagmin2-cypHer5E), and compared the retrieval kinetics of membranes and vesicular proteins at the calyx of Held synapse. Membrane and Syt2 were retrieved with a similar time course when slow endocytosis was elicited. When fast endocytosis was elicited, Syt2 was still retrieved together with the membrane, but endocytosed organelle re-acidification was slowed down, which provides strong evidence for two distinct endocytotic pathways. Strikingly, CaM inhibitors or the inhibition of the Ca2+-calmodulin-Munc13-1 signaling pathway only impaired the uptake of Syt2 while leaving membrane retrieval intact, indicating different recycling mechanisms for membranes and vesicle proteins. Our data identify a novel mechanism of stimulus-and Ca2+-dependent regulation of coordinated endocytosis of synaptic membranes and vesicle proteins
Tz-Lin Hsu Piano Recital Program Notes
No full textThis is the Program Notes of Tz-Lin Hsu\ue2s piano recital held on May 20th, 2020. The recital program includes Johann Sebastian Bach\ue2s The Well-Tempered Clavier, Book 1, Prelude and Fugue No. 17 in A-flat Major, BWV 862; Ludwig van Beethoven\ue2s Sonata No. 7 in D Major, Op. 10, No. 3, Jakob Ludwig Felix Mendelssohn Bartholdy\ue2s Fantasy in F-sharp minor, Op. 28; and Ignacy Jan Paderewski\ue2s Th\uc3\ua8me vari\uc3\ua8 in A Major, Op. 16, No. 3. The program notes will briefly introduce these four composers\ue2 lives, their compositional backgrounds, and the structure of each work, including the tonal organization and thematic materials
Shang han ming li lun
No full text張仲景述 ; 王叔和撰次 ; 成無己注解 ; 吳勉學閱 ; 徐鎔校. 傷寒明理論 : 四卷 / 成無己撰 ; 吳勉學閱 ; 徐鎔校.綫裝.框20x13.5公分, 10行20字, 小字雙行同. 白口, 四周單邊(間或左右雙邊), 單黑魚尾. 版心上鐫題名, 中鐫卷次, 下鐫葉次.書名頁刻"張仲景著傷寒論, 張卿子先生手定, 成無己註, 附諸名家, 大文堂藏板"《中國中醫古籍總目》(00671)著錄清廣州大文堂刻本.卷前附附: 醫林列傳 -- 論圖.鈐"莊兆祥印", "莊兆祥"Xian zhuang.Kuang 20 x 13.5 gong fen, 10 hang 20 zi, xiao zi shuang hang tong. Bai kou, si zhou dan bian (jian huo zuo you shuang bian), dan hei yu wei. Ban xin shang juan ti ming, zhong juan juan ci, xia juan ye ci.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Zhang Zhongjing shu ; Wang Shuhe zhuan ci ; Cheng Wuji zhu jie ; Wu Mianxue yue ; Xu Rong jiao. Shang han ming li lun : si juan / Cheng Wuji zhuan ; Wu Mianxue yue ; Xu Rong jiao.Juan qian fu fu: Yi lin lie zhuan -- Lun tu.Qian "Zhuang Zhaoxiang yin", "Zhuang Zhaoxiang
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