1,720,974 research outputs found
Studies associating blastocystis sp. tocolorectal cancer Vinoth s/o Kumarasamy
No full textCancer has become a vital public health issue around the world. Colorectal cancer (CRC) has become one of the major causes of deaths worldwide. Numerous reports have correlated infectious agents and cancer including CRC. Infectious agents are known to contribute to 20% of CRC. Recent findings have demonstrated the possible correlation between Blastocystis and CRC with many conflicting reports on the question of pathogenicity of different subtypes of Blastocystis. To improve our understanding on the molecular epidemiology of this parasite, we determined the Blastocystis subtypes (STs) and their relative frequency in CRC patients and control groups. Epidemiological studies related to Blastocystis often give poor results due to poor sensitivity of standard methods available to detect Blastocystis genotypes in the stool sample. As such,
prevalence study was conducted using colonic washouts collected from CRC patients and healthy individuals. The mean prevalence of Blastocystis infection was significantly
higher among CRC patients (n=43, 21.08%) compared to healthy control (n=22, 9.95%, p < 0.01) and subtype 3 was predominant (12.75%) among these individuals. We also
investigated immunoglobulin levels in Blastocystis positive patients who were newly diagnosed with CRC as well as those subjected to chemotherapy. We found the high infection in both newly diagnosed CRC patients and chemotherapy patients with the elevation of specific antibodies. One healthy individual who was negative for Blastocystis both by direct microscopy and in in vitro cultures had higher IgM titers
(1:1600) and 4 showed low titres of IgG antibody. A total of 11 healthy individuals were positive for IgG. Significant number of healthy individuals showed the presence of IgA with the exception of one individual who showed the presence at low titers. The finding showed the presence of association between immune response to Blastocystis
antigen and CRC. In addition, we also evaluated the effect of solubilized antigen isolated from five different subtypes of Blastocystis on colon cancer cells, HCT116 and
peripheral blood mononuclear cell (PBMC) proliferation. Evaluation of gene expression of cytokines, nuclear transcription factors and apoptotic genes in colon cancer cell and immune cells in the presence of Blastocystis was carried out. The proliferation analysis and gene expression findings in the present study implicate a possible pathogenic role for subtype 3 Blastocystis. The inhibitory effect was seen to be higher in PBMCs isolated from CRC patients compared to healthy volunteers which suggests that
Blastocystis infection may prevent immune cell propagation to combat the infection. Besides that, the parasite’s influence on the cytotoxic activity of chemotherapy drugs during cancer treatment was also assessed in this study. We designed an in vitro model to specifically analyse the effect of Blastocystis on chemotherapy drug, 5-fluorouracil (5-FU) in colon cancer cells, HCT116 and normal colon fibroblast cells, CCD18-Co. 5-FU caused a dose-dependent increase in the inhibition of cancer cell proliferation. However, the inhibitory effect was reduced in the presence of Blastocystis antigen at 8μM and 10μM of 5-FU. We speculate that Blastocystis antigen could interfere with the efficacy of 5-FU cytotoxicity towards cancer cells. Blastocystis induced expression of inflammatory cytokines, gene transcription factors and angiogenic factors that resulted in resistance of cancer cells against 5-FU. Further validation of the pathogenicity of Blastocystis was carried out using experimental animal models induced with carcinogen, azoxymethane (AOM). Increased crypts formation and increased colorectal dysplasia and elevated level of oxidative damage were observed in the presence of Blastocystis infection. The study underscores the importance of including Blastocystis infection in routine parasitological investigation among CRC patients especially when it can be easily be acquired from contaminated water, food and possibly from animals
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
- …
