867 research outputs found
Recent Advances in Multiple Myeloma
No full textOncology & Hematology Review (US) are delighted to introduce our new Editor-in-Chief, Shaji K Kumar, consultant in the Division of Hematology at Mayo Clinic, and Professor of Medicine in the College of Medicine, Mayo Clinic, Rochester, Minnesota, US. In a recent interview, Dr Kumar discussed the latest advances in multiple myeloma, one of his major research interests.</jats:p
sj-docx-1-tah-10.1177_20406207221082043 – Supplemental material for The impact of bortezomib-based induction in newly diagnosed multiple myeloma with chromosome 1q21 gain
No full textSupplemental material, sj-docx-1-tah-10.1177_20406207221082043 for The impact of bortezomib-based induction in newly diagnosed multiple myeloma with chromosome 1q21 gain by Hoi Ki Karen Tang, Chi Yeung Fung, Gareth J. Morgan, Shaji Kumar, Lisa Siu, Ho Wan Alvin Ip, Sze Fai Yip, Ka Ngai Harry Lau, Chi Kuen Lau, Harold Lee, Kwan Hung Leung, Bonnie Kho, Howard Wong, Cheong Ngai, Yu Yan Hwang, Joycelyn Sim, Yok Lam Kwong and Chor Sang Chim in Therapeutic Advances in Hematology</p
Tiphia (Tiphia) shajii Hanima & Girish Kumar 2022, sp. nov.
No full text38. Tiphia (Tiphia) shajii Hanima & Girish Kumar sp. nov. (Figs 496–508) urn:lsid:zoobank.org:act: 0B9D306B-2647-46DA-99E7-7B983507E9C4 Type material. Holotype, ♂, INDIA: Kerala, Kozhikode district, Manipuram (11°24′45″N & 75°56′20″E, 61m), 16.v.2019, Coll. C. Binoy, (ZSIK) Regd. No. ZSI / WGRC /IR/INV.18086. Paratypes: 2♂ same collection data as that of holotype, (ZSIK) Regd. Nos. ZSI / WGRC /IR/INV.18087–18088; 1♂, Wayanad district, Muthanga, Machikudi (11°40′24″N & 76°17′21″N, 913 m), 19.ii.2021, Coll. K.A. Subramanian & Party, (ZSIK) Regd. No. ZSI / WGRC / IR/INV.18911. Diagnosis. Dorsal side of propodeum transversely rugose; Gs 5 without orifice beneath edge of lateral denticle; Gs 6 with short, sparse setae; mandible without preapical denticle; Gt 1 without anterior transverse carina; fore wing with marginal cell distinctly less than second cubital cell in apical extension; tegula translucent; areola with basal width 2 × its apical width, median length 2 × its apical width. Description. Holotype, ♂. Body length 8.7 mm. Paratypes, ♂. Body Length 7.2–8.4 mm. Colour. Black with tegula amber translucent with basal portion black (Fig. 500); wings slightly yellowish infumate (Fig. 503). Head. Head coarsely and adjacently punctate at lower frontal area except below anterior ocellus and upper frontal area with sparsely arranged punctures (Fig. 497); HW 1.96 × least distance between eyes; mandible without preapical denticle (Fig. 498); clypeus with its median extension very slightly emarginated; clypeal disk with minute punctures basally and remaining portion with coarse contiguous punctures (Fig. 498); POD 2.2 × LOD and 1.03 × OOD; scape shiny, with coarse setigerous punctures, pedicel basally with deep punctures and other flagellomeres with thick setae (Fig. 502); length of scape: pedicel: Fu 1: Fu 2: Fu 3: Fu 4: Fu 5: Fu 6: Fu 7: Fu 8: Fu 9: Fu 10: Fu 11 = 0.307: 0.129: 0.193: 0.198: 0.205: 0.205: 0.206: 0.204: 0.209: 0.208: 0.203: 0.192: 0.322 (Fig. 502). Mesosoma. Dorsal side of pronotum anteriorly with obscurely ridged carina, most of the area with punctures and posteriorly (except lateral corner) with impunctate area (Fig. 500); lateral side of pronotum with distinct transdiscal groove, aciculations above the groove and ridges below the groove (Fig. 501); length of tegula 1.39× as long as its middle width (Fig. 500); mesoscutum with its notauli not connected to anteriomedian escarpment, most punctures sparsely placed (Fig. 500); scutellum with irregular sparse punctures (Fig. 500); metanotum mixed with large and small scattered punctures (Fig. 500); dorsal side of propodeum including areola coarsely rugose (Fig. 500); mesopleuron with coarse punctures (Fig. 501); lateral side of propodeum with oblique rugulae (Fig. 501); posterior side of propodeum strongly rugulose reticulate; fore wing with marginal cell distinctly less in apical extension than second cubital cell (Fig. 503). Length of mesosoma: 2.60 mm. Metasoma. All tergites smooth and shiny with punctures (Fig. 504); Gt 1 without anterior transverse carina (Fig. 504); Gs 5 with tooth like projected denticle (Fig. 505); Gs 6 with short, sparse setae (Fig. 505). Length of metasoma: 4.50 mm. Genitalia. Paramere shaped like spatula and covered with long and short setae; digitus basally broad and curved at apex; cuspis with punctures and setae and with a beak like apical part; aedeagus with rounded apical portion (Figs 506–508). Female. Unknown. Discussion. As per the key of Allen 1975, this new species comes close to T. (T.) madrasa Allen in having dorsal side of propodeum entirely and deeply transversely rugose; Gs 5 without orifice beneath edge of lateral denticle; Gs 6 with short, sparse setae; mandible without preapical denticle; Gt 1 without anterior transverse carina but this new species distinctly differs from T. (T.) madrasa in the following characters: fore wing with marginal cell distinctly less than second cubital cell in apical extension (in T. (T.) madrasa, fore wing with marginal cell greatly longer than second cubital cell in apical extension); tegula mostly orange brown colored without shagreened sculpture (in T. (T.) madrasa, tegula black with broadly shagreened sculpture); areola with basal width 2 × apical width and median length 2 × apical width (in T. (T.) madrasa, areola with basal width and median length only slightly longer than apical width). Distribution. India: Kerala. Etymology. The species is named in honor of Dr. C.P. Shaji for his dedication to the study of natural history and taxonomy of Indian freshwater fishes.Published as part of Hanima, Raveendran K. P., Kumar, Girish & Hegde, Vishwanath D., 2022, Additions to the knowledge on the genus Tiphia Fabricius (Hymenoptera: Tiphiidae: Tiphiinae) from India with the description of ten new species, pp. 1-106 in Zootaxa 5204 (1) on pages 94-96, DOI: 10.11646/zootaxa.5204.1.1, http://zenodo.org/record/728519
Short-term intense Bcr-Abl kinase inhibition with nilotinib is adequate to trigger cell death in BCR-ABL(+) cells
No full textD.K. Hiwase, D.L. White, V.A. Saunders, S. Kumar, J.V. Melo and T.P. Hughe
Guidelines for non-transplant chemotherapy for treatment of systemic AL amyloidosis: EHA-ISA working group
No full textBackground: This guideline has been developed jointly by the European Society of Haematology and International Society of Amyloidosis recommending non-transplant chemotherapy treatment for patients with AL amyloidosis. Methods: A review of literature and grading of evidence as well as expert recommendations by the ESH and ISA guideline committees. Results and Conclusions: The recommendations of this committee suggest that treatment follows the clinical presentation which determines treatment tolerance tempered by potential side effects to select and modify use of drugs in AL amyloidosis. All patients with AL amyloidosis should be considered for clinical trials where available. Daratumumab-VCD is recommended from most untreated patients (VCD or VMDex if daratumumab is unavailable). At relapse, the two guiding principles are the depth and duration of initial response, use of a class of agents not previously exposed as well as the limitation imposed by patients’ fitness/frailty and end organ damage. Targeted agents like venetoclax need urgent prospective evaluation. Future prospective trials should include advanced stage patients to allow for evidence-based treatment decisions. Therapies targeting amyloid fibrils or those reducing the proteotoxicity of amyloidogenic light chains/oligomers are urgently needed
Differential cytopathology and kinetics of measles oncolysis in T=two primary B-cell malignancies provides mechanistic insights
No full textClinical trials using vaccine measles virus (MV) as anticancer therapy are already underway. We compared the oncolytic potential of MV in two B-cell malignancies; adult acute lymphoblastic leukemia (ALL, an aggressive leukemia) and chronic lymphocytic leukemia (CLL, an indolent leukemia overexpressing Bcl-2) using patient-derived material. In vitro, distinct cytopathological effects were observed between MV-infected primary ALL and CLL cells, with large multinucleated syncytia forming in ALL cultures compared to minimal cell-to-cell fusion in infected CLL cells. Cell viability and immunoblotting studies confirmed rapid cell death in MV-infected ALL cultures and slower MV oncolysis of CLL cells. In cell lines, overexpression of Bcl-2 diminished MV-induced cell death providing a possible mechanism for the slower kinetic of MV oncolysis in CLL. In vivo, intratumoral MV treatment of established subcutaneous ALL xenografts had striking antitumor activity leading to complete resolution of all tumors. The antitumor activity of MV was also evident in disseminated ALL xenograft models. In summary, both ALL and CLL are targets for MV-mediated lysis albeit with different kinetics. The marked sensitivity of both primary ALL cells and ALL xenografts to MV oncolysis highlights the tremendous potential of MV as a novel replicating-virus therapy for adult AL
Holistic treatment of chronic myeloid leukaemia with adjuvant homoeopathic therapy: A case report
No full textIntroduction: Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder of haematopoietic stem cell. Case Summary: This is a case of a 28-year-old female having CML for 1½ years, on regular allopathic medication. The patient was suffering from ulceration in the oral cavity, frequent offensive loose stools with melena and prolonged menstrual cycle with heavy bleeding for 3 weeks. After analysing the constitutional make-up of the patient, Platinum metallicum 200C was prescribed. Over a period of 3 months, the patient reported improvement in weakness, nausea, sleeplessness, irritability, heavy menstruation, loose black stools and backache. Until the last follow-up while submitting this report, the patient was on the maintenance dose of Imatinib along with homoeopathic medication
Contextual Form Based Coding as a Tool in Urban Design Process-chalai, Thiruvananthapuram as a Case
No full textAbstractThe present urbanized world is on a vogue to remold its impression and character into someone else's. The new impressions often carries a complete disconnect from its roots which gradually loses its self and identity and never has a sustenance. In this context Form Based Coding(FBC) as a tool in Urban Design Process aids to come up with solutions whichstrongly holds the people to their community and closelyassociated with culture through the physical spaces they areassociated with. The paper has made an effort to analyze theprocess of FBC as a genuine tool to establish the association ofphysical form and spaces with the public realm to uphold thecontext and culture by taking a case in the heritage rich centralcommercial core of Thiruvananthapuram city, Chalai. Chalai isundergoing a tremendous transformation in its physical formdisregarding its strong culture and context and this can influencethe inherent native character of the bazaar activity and looses itsidentity in form and function. In this regard form Based Codingwill be a suitable tool to strengthen it as a native bazaar for thecity.A detailed documentation of form in relation with the existing layers of street pattern, activity, building types, and function is analysed and its influences to variations in form is studied. The existing codes of the built form of different uses were decoded. The comparison of existing codes with the theoretical parameters from literature and case studies lead to the formulation of codes with FBC as a tool suitable for the context
- …
