1,722,277 research outputs found
Fig. 3 in An overview of acyclotides: Past, present and future
No full textFig. 3. Multiple Sequence Alignment of acyclotides. All acyclotides with D (Asp)/N(Asn) at C-terminal end are acyclic analogues of cyclotides, whereas those ending with stop codon (*) are genetically predetermined acyclotides.Published as part of Tammineni, Ramya, Gulati, Pooja, Kumar, Sanjay & Mohanty, Aparajita, 2020, An overview of acyclotides: Past, present and future, pp. 112215 in Phytochemistry (112215) 170 on page 4, DOI: 10.1016/j.phytochem.2019.112215, http://zenodo.org/record/816028
Fig. 4 in An overview of acyclotides: Past, present and future
No full textFig. 4. Diversity in gene architecture of acyclotides from six angiosperm families (Violaceae, Rubiaceae, Fabaceae, Poaceae, Solanaceae, Cucurbitaceae). (ER- Endoplasmic Reticulum, NTPP- N terminal propeptide, NTR- N terminal repeat, CTPP- C terminal propeptide CTR- C terminal repeat, A1a- Albumin 1 domain -chain A).Published as part of Tammineni, Ramya, Gulati, Pooja, Kumar, Sanjay & Mohanty, Aparajita, 2020, An overview of acyclotides: Past, present and future, pp. 112215 in Phytochemistry (112215) 170 on page 4, DOI: 10.1016/j.phytochem.2019.112215, http://zenodo.org/record/816028
N-Cadherin adhesive ligation regulates mechanosensitive neural stem cell lineage commitment in 3D matrices
No full textDuring differentiation, neural stem cells (NSCs) encounter diverse cues from their niche, including not only biophysical cues from the extracellular matrix (ECM) but also cell-cell communication. However, it is still poorly understood how these cues cumulatively regulate mechanosensitive NSC fate commitment, especially in 3D matrices that better mimic in vivo systems. Here, we develop a click chemistry-based 3D hydrogel material system to fully decouple cell-cell and cell-ECM interactions by functionalizing small peptides: the HAVDI motif from N-cadherin and RGD motif from fibronectin. The hydrogel is engineered to range in stiffness from 75 Pa to 600 Pa. Interestingly, HAVDI-mediated interaction shows increased neurogenesis, except for the softest gel (75 Pa). Moreover, the HAVDI ligation attenuates the mechanosensing state of NSCs, exhibiting restricted cytoskeletal formation and RhoA signaling. Given that mechanosensitive neurogenesis has been reported to be regulated by cytoskeletal formation, our finding suggests that the enhanced neurogenesis in the HAVDI-modified gel may be highly associated with the HAVDI interaction-mediated attenuation of mechanosensing. Furthermore, NSCs in the HAVDI gel shows higher beta-catenin activity, which has been known to promote neurogenesis. Our findings provide critical insights into how mechanosensitive NSC fate commitment is regulated as a consequence of diverse interactions in 3D microenvironments.
N-cadherin adhesive interaction of human neural stem cells affects the mechanosensitive fate commitment in a three-dimensional environment
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Equatorial Ionospheric Anomaly (EIA) and comparison with IRI model during descending phase of solar activity (2005– 2009)
No full textThe ionospheric variability at equatorial and low latitude region is known to be extreme as compared to mid latitude region. In this study the ionospheric total electron content (TEC), is derived by analyzing dual frequency Global Positioning System (GPS) data recorded at two stations separated by 325 km near the Indian equatorial anomaly region, Varanasi (Geog latitude 25°, 16/ N, longitude 82°, 59/ E, Geomagnetic latitude 16°, 08/ N) and Kanpur (Geog latitude 26°, 18/ N, longitude 80°, 12/ E, Geomagnetic latitude 17°, 18/ N). Specifically, we studied monthly, seasonal and annual variations as well as solar and geomagnetic effects on the equatorial ionospheric anomaly (EIA) during the descending phase of solar activity from 2005 to 2009. It is found that the maximum TEC (EIA) near equatorial anomaly crest yield their maximum values during the equinox months and their minimum values during the summer. Using monthly averaged peak magnitude of TEC, a clear semi-annual variation is seen with two maxima occurring in both spring and autumn. Results also showed the presence of winter anomaly or seasonal anomaly in the EIA crest throughout the period 2005–2009 only except during the deep solar minimum year 2007–2008. The correlation analysis indicate that the variation of EIA crest is more affected by solar activity compared to geomagnetic activity with maximum dependence on the solar EUV flux, which is attributed to direct link of EUV flux on the formation of ionosphere and main agent of the ionization. The statistical mean occurrence of EIA crest in TEC during the year from 2005 to 2009 is found to around 12:54 LT hour and at 21.12° N geographic latitude. The crest of EIA shifts towards lower latitudes and the rate of shift of the crest latitude during this period is found to be 0.87° N/per year. The comparison between IRI models with observation during this period has been made and comparison is poor with increasing solar activity with maximum difference during the year 2005.Accepted versio
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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