1,721,208 research outputs found
sj-docx-1-son-10.1177_23779608231159631 - Supplemental material for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses
No full textSupplemental material, sj-docx-1-son-10.1177_23779608231159631 for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses by Hailye Mitike, MSc, Wondwossen Yimam, MSc, Debrnesh Goshiye, MSc and Kumar Prem Kumar, PhD in SAGE Open Nursing</p
sj-tif-4-son-10.1177_23779608231159631 - Supplemental material for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses
No full textSupplemental material, sj-tif-4-son-10.1177_23779608231159631 for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses by Hailye Mitike, MSc, Wondwossen Yimam, MSc, Debrnesh Goshiye, MSc and Kumar Prem Kumar, PhD in SAGE Open Nursing</p
sj-tif-3-son-10.1177_23779608231159631 - Supplemental material for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses
No full textSupplemental material, sj-tif-3-son-10.1177_23779608231159631 for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses by Hailye Mitike, MSc, Wondwossen Yimam, MSc, Debrnesh Goshiye, MSc and Kumar Prem Kumar, PhD in SAGE Open Nursing</p
sj-tif-2-son-10.1177_23779608231159631 - Supplemental material for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses
No full textSupplemental material, sj-tif-2-son-10.1177_23779608231159631 for Knowledge, Attitudes, Practices, and Associated Factors Towards Care of Elderly Patients among Nurses by Hailye Mitike, MSc, Wondwossen Yimam, MSc, Debrnesh Goshiye, MSc and Kumar Prem Kumar, PhD in SAGE Open Nursing</p
Holographic Coulomb branch solitons, quasinormal modes, and black holes
Full text linkFour-dimensional N=4 supersymmetric Yang-Mills theory, at a point on the Coulomb branch where SU(N) gauge symmetry is spontaneously broken to SU(N − 1) × U(1), admits BPS solitons describing a spherical shell of electric and/or magnetic charges enclosing a region of unbroken gauge symmetry. These solitons have been proposed as gauge theory models for certain features of asymptotically flat extremal black holes. In the ’t Hooft large N limit with large ’t Hooft coupling, these solitons are holographically dual to certain probe D3-branes in the AdS5 ×S5 solution of type IIB supergravity. By studying linearised perturbations of these D3-branes, we show that the solitons support quasinormal modes with a spectrum of frequencies sharing both qualitative and quantitative features with asymptotically flat extremal black holes
Interaction of anaesthetics with the carotid body glomus cell and the background potassium channel response to hypoxia
Full text linkThis thesis investigates the role anaesthetics play in the depression of the acute hypoxic and hypercapnic ventilatory response. Particular attention is paid to TASK (TWIK related acid sensitive potassium) channels that are known to be sensitive to both hypoxia and the volatile anaesthetics. After chapters relating to a general introduction and methods, chapter 3 describes studies into the hypoxic and hypercapnic responses of mice with genetic ablation of TASK 1 and/or TASK 3. By using whole animal unrestrained plethysmography, it was demonstrated that any loss of TASK channels resulted in a depression of ventilatory responses to hypoxia and hypercapnia. In isocapnic hypoxia, there is a genotype specific depression by anaesthetics of the remaining AHVR, depending on whether halothane or isoflurane is inspired. Chapter 4 establishes that propofol depresses the chemosensory responses of carotid body glomus cells. Using ratiometric flurimetry to measure the intracellular calcium concentration in isolated neonatal rat glomus cells, it was demonstrated that propofol depresses the normal cellular response to both hypoxia and hypercapnia. Using pharmacological modulators of GABA and nAChR, and single channel patch clamp electrophysiology of TASK, it is apparent that this depression is independent of these candidate mechanisms. Chapter 5 describes the effects of the anaesthetic dexmedetomidine at two levels of the hypoxic chemoreflex arc in rodents. Neither isolated rat glomus cells, nor unrestrained mice show significant depression of hypoxic responses when dexmedetomidine is present. Chapter 6 illustrates the potential role for specific antagonism of TASK channels in stimulating the carotid body. Two TASK channel blockers, A1899 (TASK 1 antagonist) and PK-THPP (TASK 3 antagonist) are shown to cause a significant influx of calcium into isolated glomus cells, and an augmentation in the glomus cell response to hypoxia, which persists in the presence of isoflurane. Overall, this thesis provides evidence that both TASK 1 and TASK 3 channels are essential for normal hypoxic chemosensitivity. It has extended the knowledge that anaesthetics depress glomus cell chemosensation, by demonstrating that propofol too causes this effect. It also proposes that dexmedetomidine may have greater utility in sparing of ventilatory reflexes. By selectively blocking TASK channels, glomus cells can be stimulated, and exploiting this mechanism would be useful in minimising anaesthetic-induced depression of ventilation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Experimental investigation of machining rate, geometrical accuracy and optimization of machining parameters in electrochemical micromachining of stainless steel 304
No full textThis study investigates the influence of sodium chloride-based electrolytes on the electrochemical micromachining (ECMM) process of stainless steel SS304, a material widely used in the automotive industry. The research focuses on two electrolyte combinations: Tamarind + NaCl and Succinic acid + NaCl, and their effects on material removal rate (MRR), overcut, and circularity. Using the Taguchi design of experiments, the study examines the impact of process parameters such as applied voltage, electrolytic concentration, frequency, and duty cycle on machining characteristics. The results demonstrate that the Tamarind + NaCl electrolyte combination achieves the highest MRR, with an approximate increase of 29.24% compared to the Succinic acid + NaCl combination. Additionally, the Tamarind + NaCl combination exhibits a 47.45% improvement in overcut and superior machining performance in terms of circularity error. Multi-response optimization techniques, including Grey Relational Analysis (GRA) and Desirability Function Analysis (DFA), are employed to identify optimal parameter combinations. GRA suggests that a voltage of 12 V, an electrolyte concentration of 20% (10 + 10 g/L), a pulse frequency of 80 Hz, and a duty cycle of 50% result in the highest MRR and minimum overcut and circularity error for the Tamarind + NaCl combination. DFA is used to optimize multiple quality indicators simultaneously, minimizing or maximizing responses within the specified range of process parameters. The findings emphasize the importance of electrolyte selection and process parameter optimization in enhancing the efficiency and effectiveness of ECMM processes for machining high-strength materials like stainless steel SS304, with significant implications for various industrial applications, particularly in the automotive sector
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