8 research outputs found
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies
No full textFunding Information: Dr. Niraj Kumar Jha is thankful to Sharda University for the infrastructure and facility. The author would like to thank Deanship of Scientific Research at Majmaah University for supporting this work under project number No. R-2022-68 . Kavindra Kumar Kesari and Janne Ruokolainen thanking Aalto University for providing open access support. The authors would like to acknowledge the support from their respective institutes throughout the review writing process.Purpose: Cervical cancer (CC), one of the major causes of death of women throughout the world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region (E) oncoproteins of HPV are associated with the etiopathogenesis and contribute to the progression of cancer. The present article comprehensively discussed the structural organization and biological functions of all E proteins of HPV and their contribution to progression of CC with an intent to decipher the pathological hallmarks and their relationship. Additionally, the role of E proteins in reference to therapeutics will also be presented. Methods: A systematic search has been carried out for articles published in PubMed database by using combinations of different keywords with Boolean operators (AND, OR, NOT) including cervical cancer, HPV, E proteins, and signaling. Results: From the analysis of literature review, its apparent that E proteins are the major contributor to disease progression. E1, E2, and E4 forms are mainly associated with viral integration, replication, and transcription whereas E6 and E7 act as an oncoprotein and are associated with the progression of cancer. E5 regulates cell proliferation, apoptosis, and facilitates the activity of E6 and E7. Additionally, E proteins were observed associated with numerous cell signaling pathways including PI3K/AKT, Wnt, Notch and reasonably contribute to the initiation of malignancy, cell proliferation, metastasis, and drug resistance. Knowing the role and interplay of each protein in initiation to progression of CC, their therapeutic significance has been elucidated. The present study observations demonstrate that E6 and E7 are the major cause of HPV-mediated CC progression. E1, E2, and E5 also act as a backbone for E6 and E7 and most of the current approaches have targeted E6 and E7 mediated action only. Conclusion: The present review illustrates the structural organization as well as function and regulation of all early proteins of HPV and their association with several cellular signaling pathways. The observations provide clue on the regulatory aspect of these proteins in initiation to progression and reasonably represent that targeting these proteins could be a novel therapeutic strategy for CC. In particular, its seemingly appears that inhibition of the activity of E6 and E7 oncoproteins may be a better selective target to delay the progression of CC. The review reaffirms the role of E proteins and encourages future studies on developing diagnostics, and most importantly therapeutics strategies targeting E6 and E7 oncoproteins to tackle CC related morbidity and mortality.Peer reviewe
Henry David Thoreau e as Linguagens da Natureza
No full textThis dissertation aims to present a hermeneutic reading of some of the religious symbols
brought to light by the literature of the poet and naturalist Henry David Thoreau (1817–1862).
The background of our argument is the romantic motto of the symbolic correspondence between
Nature and spirit, inherited by the author from his contact with the movement that became
known as “Transcendentalism,” a religious, literary, philosophical, and political circle gestated
in the Nineteenth-century United States. From this panorama, we draw a poetic appreciation of
the thinker’s interpretation of the linguistic correlation between Nature and spirit that points to
the unity between the immanence of natural kingdoms (the earth) and the transcendence of the
spiritual spheres (the sky). Emphasizing the sacred character of the symbols hinted by
Thoreau’s texts, those emblems we call “mythopoetic hieroglyphs” and “musical hieroglyphs.”
Beyond the tonalities of romanticism, the work proposed here, evoking distinct religious paths,
seeks to highlight the multiple reflective possibilities that the North American thinker offers to
comparative studies of religions, given the mark of dialogicity between different wisdom
traditions in his composition. Highlighting seeing and hearing (i.e., reading and listening to the
“book” and the “orchestra” of Nature), our exposition aims to unravel the intimate relationship
between spirituality and bodily sensibility in the intellectual’s approach to those we call
“Languages of Nature.”A presente dissertação tem por objetivo apresentar uma leitura hermenêutica de alguns
dos símbolos religiosos trazidos à baila pela literatura do poeta e naturalista Henry David
Thoreau (1817–1862). O pano de fundo de nossa argumentação é o mote romântico da
correspondência simbólica entre Natureza e espírito, herdado pelo autor a partir de seu contato
com o movimento que se tornou conhecido como “Transcendentalismo”, círculo religioso,
literário, filosófico e político gestado nos Estados Unidos do século XIX. A partir desse
panorama, traçamos uma apreciação poética da interpretação de Thoreau acerca da correlação
linguística entre Natureza e espírito que aponta para a unidade entre a imanência dos reinos
naturais (a terra) e a transcendência das esferas espirituais (o céu). Ressaltando o caráter sagrado
dos símbolos aventados pelos textos thoreauvianos, tais emblemas são aqui denominados
“hieróglifos mitopoéticos” e “hieróglifos musicais”. Para além das tonalidades do romantismo,
o trabalho aqui proposto, evocando distintos sendeiros religiosos, busca realçar as múltiplas
possibilidades reflexivas que o pensador norte-americano oferece aos estudos comparativos das
religiões, haja vista a marca da dialogicidade entre diversas tradições sapienciais em sua obra.
Destacando o ver e o ouvir (i.e., a leitura e a audição do “livro” e da “orquestra” da Natureza),
nossa exposição tem por intuito deslindar a íntima relação entre espiritualidade e sensibilidade
corpórea na abordagem do intelectual daquelas que intitulamos “Linguagens da Natureza”.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superio
Crosstalk between long noncoding RNA and microRNA in Cancer
No full textFunding Information: We thank Aalto University for providing open-access support. NP would like to acknowledge Finnish cultural foundation (Varsinais-Suomi regional fund.) Publisher Copyright: © 2023, The Author(s).miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].Peer reviewe
Nanotheranostics to target antibiotic-resistant bacteria: Strategies and applications
No full textVarious health agencies, such as the European Medical Agency (EMA), Centers for Disease Control and Prevention (CDC), and World Health Organization (WHO), timely cited the upsurge of antibiotic resistance as a severe threat to the public health and global economy. Importantly, there is a rise in nosocomial infections among covid-19 patients and in-hospitalized patients with the delineating disorder. Most of nosocomial infections are related to the bacteria residing in biofilm, which are commonly formed on material surfaces. In biofilms, microcolonies of various bacteria live in syntropy; therefore, their infections require a higher antibiotic dosage or cocktail of broad-spectrum antibiotics, aggravating the severity of antibiotic resistance. Notably, the lack of intrinsic antibacterial properties in commercial-grade materials desires to develop newer functionalized materials to prevent biofilm formation on their surfaces. To devise newer strategies, materials prepared at the nanoscale demonstrated reasonable antibacterial properties or enhanced the activity of antimicrobial agents (that are encapsulated/chemically functionalized onto the material surface). In this manuscript, we compiled such nanosized materials, specifying their role in targeting specific strains of bacteria. We also enlisted the examples of nanomaterials, nanodevice, nanomachines, nano-camouflaging, and nano-antibiotics for bactericidal activity and their possible clinical implications
The paradigm of miRNA and siRNA influence in Oral-biome
No full textShort nucleotide sequences like miRNA and siRNA have attracted a lot of interest in Oral-biome investigations. miRNA is a small class of non-coding RNA that regulates gene expression to provide effective regulation of post-transcription. On contrary, siRNA is 21-25 nucleotide dsRNA impairing gene function post-transcriptionally through inhibition of mRNA for homologous dependent gene silencing. This review highlights the application of miRNA in oral biome including oral cancer, dental implants, periodontal diseases, gingival fibroblasts, oral submucous fibrosis, radiation-induced oral mucositis, dental Pulp, and oral lichenoid disease. Moreover, we have also discussed the application of siRNA against the aforementioned disease along with the impact of miRNA and siRNA to the various pathways and molecular effectors pertaining to the dental diseases. The influence of upregulation and downregulation of molecular effector post-treatment with miRNA and siRNA and their impact on the clinical setting has been elucidated. Thus, the mentioned details on application of miRNA and siRNA will provide a novel gateway to the scholars to not only mitigate the long-lasting issue in dentistry but also develop new theragnostic approaches
Posterity of nanoscience as lipid nanosystems for Alzheimer's disease regression
No full textAlzheimer's disease (AD) is a type of dementia that affects a vast number of people around the world, causing a great deal of misery and death. Evidence reveals a relationship between the presence of soluble A & beta; peptide aggregates and the severity of dementia in Alzheimer's patients. The BBB (Blood Brain Barrier) is a key problem in Alzheimer's disease because it prevents therapeutics from reaching the desired places. To address the issue, lipid nanosystems have been employed to deliver therapeutic chemicals for anti-AD therapy in a precise and targeted manner. The applicability and clinical significance of lipid nanosystems to deliver therapeutic chemicals (Galantamine, Nicotinamide, Quercetin, Resveratrol, Curcumin, HUPA, Rapamycin, and Ibuprofen) for anti-AD therapy will be discussed in this review. Furthermore, the clinical implications of the aforementioned therapeutic compounds for anti-AD treatment have been examined. Thus, this review will pave the way for researchers to fashion therodiagnostics approaches based on nanomedicine to overcome the problems of delivering therapeutic molecules across the blood brain barrier (BBB)
Cellular landscaping of cisplatin resistance in cervical cancer
No full textPublisher Copyright: © 2022 The AuthorsCervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments.Peer reviewe
Corrigendum to “Cellular landscaping of cisplatin resistance in cervical cancer” Biomed. Pharmacother. 153(2022) 113345 (Biomedicine & Pharmacotherapy (2022) 153, (S075333222200734X), (10.1016/j.biopha.2022.113345))
No full textPublisher Copyright: © 2024 The AuthorsThe authors regret that incorrect information was given in the citation list of the publication The incorrect references and their corrections are as follows: Reference 27 should be same as reference 245 Reference 75 should be same as reference 82 Reference 274 should be same as reference 276 Reference 53 should be: Li, Q., Peng, X., Yang, H., Rodriguez, J. A., & Shu, Y. (2012). Contribution of organic cation transporter 3 to cisplatin cytotoxicity in human cervical cancer cells. Journal of pharmaceutical sciences, 101(1), 394–404. Reference 61 Should be: Waalkes, M. P., Liu, J., Kasprzak, K. S., & Diwan, B. A. (2006). Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: Production of hepatocellular carcinoma at clinically relevant doses. International journal of cancer, 119(1), 28–32. https://doi.org/10.1002/ijc.21245 References 69, and 73 should be: Wang, N., Hou, M. S., Zhan, Y., Shen, X. B., & Xue, H. Y. (2018). MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway. European Review for Medical & Pharmacological Sciences, 22(22). Reference 96 should be: Chen SH, Chang JY. New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. Int J Mol Sci. 2019 Aug 24;20(17):4136. doi: 10.3390/ijms20174136 Reference 229 should be: O′Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018). Overview of microRNA biogenesis, mechanisms of actions, and circulation. Frontiers in endocrinology, 9, 402. Reference 247 should be: Schräder, M., Nayeri, S., Kahlen, J. P., Müller, K. M., & Carlberg, C. (1995). Natural vitamin D3 response elements formed by inverted palindromes: polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid X receptor heterodimer-mediated transactivation. Molecular and cellular biology, 15(3), 1154–1161. References 4, 156, 180, 199, 270, 273, are unnecessary and can be deleted The authors would like to apologise for any inconvenience caused.Peer reviewe
