699 research outputs found
Irreducibility via location of zeros
No full textIn this paper, we obtain several new classes of irreducible polynomials
having integer coefficients whose zeros lie inside an open disk around the
origin or outside a closed annular region in the complex plane. Such
irreducible polynomials are devised by imposing Perron--type sufficiency
conditions on their coefficients.Comment: 10 pages (Some errors corrected, and equivalence of a Lemma of Singh
and Kumar with that of Bonciocat et al. is proved
Cost-Benefit Analysis of Single Unit Systems Using Matlab
No full textThe present chapter focuses on the development of a stochastic model for a one-unit system in which unit fails completely either directly from normal mode or via partial failure. The partially failed operating unit is shutdown after a maximum operation time for preventive maintenance (PM). There is a single server who attends the system immediately whenever needed. The unit becomes degraded after repair. The server inspects the degraded unit at its failure to see the feasibility of repair. If the repair of the degraded unit is not feasible, it is replaced by new unit. The distributions of failure, maximum rate of operation times, preventive maintenance, inspection and repair time of the unit are arbitrary distributed. By using regenerative point technique some reliability characteristic of interest are also obtained
Study of Industrial Systems Using Supplementary Variable Technique
No full textM.Sc. (Mathematics and Computing)The whole range of our work reported in this dissertation is covered into four chapters which are
described as:
Chapter-1: This Chapter is introductory in nature and contains the basic concepts including reliability
engineering, reliability theory and modeling, system configurations, Lagrange’s Method and Runge-kutta
4th order Method.
Chapter-2:
This Chapter discusses the comparison between the availability of a pipe manufacturing industry when
the Sub-Systems are subjected to simultaneously and independent failure. The failure rates of the
subsystem are constant and repair rates are variable. Availability analysis of a system can benefit the
industry in terms of higher productivity and low maintenance cost. It is possible to improve the
availability of the of the plant with proper maintenance planning and monitoring. Reliability analysis
helps us to obtain the necessary information about the control of various parameters.
Chapter-3:
The main intension of this Chapter is to develop and analyze a reliability model for polytube industry
using supplementary variable technique. A mathematical model for the system is given in the form of
differential difference equations and solved for obtaining steady state availability. The effect of various
subsystems on the availability is also studied taking numerical data.
Chapter-4:
In this Chapter we discuss the finding of Chapter-2 and Chapter-3.School of Mathematics and Computer Applications, Thapar University, Patial
Liposome-based complex injectables: a note on scale-up processes
No full textLiposome-based complex injectables epitomize a rapidly expanding area in pharmaceutical research and development as they can enhance drug solubility, drug delivery and targeted efficacy, predominantly in oncology, infectious diseases, and vaccines. However, the transformation from laboratory-scale production to bulk manufacturing presents significant challenges due to the intricate attributes of liposomal formulation. This chapter presents a comprehensive analysis of the essential considerations in scaling up liposome-based injectables. The focus is on ensuring consistent product quality, effectiveness, and safety throughout every stage of the process. The impact of the critical components and characteristics of liposomes mainly their size, lamellarity, and surface charge, on the design and optimization of large-scale production processes have been discussed thoroughly. A plethora of production methods, like thin-film hydration, microfluidics, and extrusion, and all other complexities of scaling up these techniques require critical scrutiny for successful production at commercial scale. A deep understanding of upholding critical quality attributes of liposomes like particle uniformity, encapsulation efficiency, and sterility during large-scale manufacturing, as well as the role of advanced characterization techniques in ensuring quality control has been delibrated. Furthermore, the regulatory contemplations for scaling up liposome-based products, including the need for robust process validation and compliance with good manufacturing practices (GMPs), are addressed. This chapter concludes by delving into the future prospects in liposomal drug delivery, accentuating the advancements in manufacturing and automation that could facilitate the scale-up process. Moreover, it provides valuable perspectives on upcoming technologies that could streamline and improve large-scale production
Tribology of Metal Additively Manufactured Materials
No full textMetal Additive Manufacturing (MAM) is an improved version of Additive Manufacturing (AM) that transformed AM into industrial manufacturing for building high-performance functional end-use components. MAM techniques use high-power sources for melting feedstock material. MAM processes can be largely categorized as per the material feeding techniques such as Powder Bed Fusion and Directed Energy Deposition. MAM finds application in aerospace, automotive, nuclear, and medical sectors. It is essential to understand the structure-property correlation of MAM-built components in as-built and post-processed conditions to qualify the material for various applications. The tribological properties of MAM components are significant for applications that require excellent surface properties. Thus, the present chapter explains the tribological behaviour of MAM parts. Firstly, a review of the different MAM processes is described. Further, the influence of the process parameters on wear characteristics is explained along with the effect of surface roughness. The influence of microstructure and texture on the tribological behaviour of MAM-built parts is also explained. A review of post-processing and its influence on the tribological behaviour of MAM-built parts is also presented. The chapter will be a reference material for novices and researchers working on MAM and tribological behaviour
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Resilience during the COVID-19 pandemic: The Alstom Bombardier transportation acquisition
No full textIn January 2021, Alstom announced the completion of its acquisition of Bombardier Transportation (BT), a deal worth €5.5bn first announced a year earlier, just before the global COVID-19 outbreak. The success of Alstom’s large-scale cross-border acquisition of BT is a remarkable demonstration of corporate resilience. This case study contributes to the literature by examining corporate resilience, in particular Mergers and Acquisitions (M&A) in the context of various risks and uncertainties such as macroeconomic and regulatory risks, as well as the uncertainty caused by the COVID-19 crisis. In the face of these risks and uncertainties, Alstom managed to build resilience by successfully implementing a range of strategies and effectively leveraging key capabilities which enabled it to complete its acquisition of BT
Managing employee well-being during Covid-19
No full textDespite growing body of research on employee well-being during the global crisis of Covid-19, there is a lack of research that empirically examines its antecedents. Based on the concept of subjective well-being (SWB), the purpose of our study is to examine the crucial role of self-esteem, optimism and mastery toward employee well-being, with a particular focus on the IT sector of India. The current study examines the drivers of worker’s well-being. Uncovering the links among self-esteem, optimism, and workplace well-being can form the basis of the productivity of the workforce. We used cross-sectional survey data gathered from 274 workers from the IT sector in India and followed a linear regression approach to set up the link among antecedents of subjective well-being. To assess the association among variables, a regression analysis was done. We hypothesize that self-esteem, optimism, and mastery impact the SWB of employees. The findings revealed a positive effect of Self-Esteem, Optimism, and Mastery on SW
Mapping the landscape of virtual word of mouth (v-WOM) in the tourism sector: A bibliometric review
No full textThe increasing significance of virtual word of mouth (v-WOM) in the digital era has the potential to revolutionize consumer decision-making across a wide range of markets such as tourism. The objective is to review the literature on v-WOM published between 2013 and 2023 and the research employs bibliometric analysis to examine 718 documents from the Scopus database. For performance and science mapping analysis, Biblioshiny and VOSviewer were utilized. The growing trend in publication and citation numbers shows that v-WOM is a growing field and the prominent journals involving tourism research are Tourism Management and International Journal of Hospitality Management. Robert Law is a well-known author and China has the greatest number of publications. The conceptual themes of v-WOM literature were formed by the co-occurrence analysis of keywords and bibliographic coupling networks. In order to provide insights for the future, a word cloud analysis of 549 documents published in the previous four years was also carried out
Magnetic removal of Entamoeba cysts from water using chitosan oligosaccharide-coated iron oxide nanoparticles
No full textSudeep Shukla,1 Vikas Arora,2 Alka Jadaun,3 Jitender Kumar,1 Nishant Singh,1 Vinod Kumar Jain1 1School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India; 2Department of Chemistry, Indian Institute of Technology, New Delhi, Delhi, India; 3School of Biotechnology, Jawaharlal Nehru University, New Delhi, Delhi, India Abstract: Amebiasis, a major health problem in developing countries, is the second most common cause of death due to parasitic infection. Amebiasis is usually transmitted by the ingestion of Entamoeba histolytica cysts through oral–fecal route. Herein, we report on the use of chitosan oligosaccharide-functionalized iron oxide nanoparticles for efficient capture and removal of pathogenic protozoan cysts under the influence of an external magnetic field. These nanoparticles were synthesized through a chemical synthesis process. The synthesized particles were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and zeta potential analysis. The particles were found to be well dispersed and uniform in size. The capture and removal of pathogenic cysts were demonstrated by fluorescent microscopy, transmission electron microscopy, and scanning electron microscopy (SEM). Three-dimensional modeling of various biochemical components of cyst walls, and thereafter, flexible docking studies demonstrate the probable interaction mechanism of nanoparticles with various components of E. histolytica cyst walls. Results of the present study suggest that E. histolytica cysts can be efficiently captured and removed from contaminated aqueous systems through the application of synthesized nanoparticles. Keywords: amebiasis, water treatment, nanotechnolog
How psychological ownership stimulates participation in online brand communities? The moderating role of member type
No full textHOW PSYCHOLOGICAL OWNERSHIP STIMULATES PARTICIPATION IN ONLINE BRAND COMMUNITIES? THE MODERATING ROLE OF MEMBER TYPE
How psychological ownership stimulates participation in online brand communities? The moderating role of member type (-
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