42 research outputs found
“ROLE OF DURVADI TAILA IN MANAGEMENT OF PARIKARTIKA (FISSURE –IN-ANO) IN SHALYA TANTRA”- A CLINICAL STUDY
No full textVirendra Kumar Lahari*, Balendra Singh and Uttam Kumar Nirmalka
KUTAJADI RASAKRIYA - A POLYHERBAL FORMULATION FOR MANAGEMENT OF RAKTARSHA (BLEEDING PILES) –A REVIEW STUDY
No full textDr. Alok Kumar Nirala*, Dr. Virendra Kumar Lahari, Dr. Balendra Singh, Dr. Uttam Kumar Nirmalka
REVIEW ARTICLE: KHARSUTRA PREPARATION TECHNIQUES & APPLICTION
No full textVirendra Kumar Lahari*, Alok Kumar Nirala Balendra Singh and Uttam Kumar Nirmalka
Copper-Mediated β-Amyloid Toxicity and its Chelation Therapy in Alzheimer's Disease
No full textAbstract The link between bio-metals, Alzheimer's disease (AD), and its associated protein, amyloid-β (Aβ) is very complex and one of the most studied aspects currently. Alzheimer's disease, a progressive neurodegenerative disease, is proposed to occurs due to the misfolding and aggregation of Aβ. Dyshomeostasis of metal ions and their interaction with Aβ has largely been implicated in AD. Copper plays a crucial role in amyloid-β toxicity and AD development potentially occurs through direct interaction with the copper-binding motif of APP and different amino acid residues of Aβ. Previous reports suggest that high levels of copper accumulation in the AD brain result in modulation of toxic Aβ peptide levels, implicating the role of copper in the pathophysiology of AD. In this review, we explore the possible mode of copper ion interaction with Aβ which accelerates the kinetics of fibril formation and promote amyloid-β mediated cell toxicity in Alzheimer's disease and the potential use of various copper chelators in the prevention of copper-mediated Aβ toxicity
Vibration of Buildings to Wind and Earthquake Loads
No full textRecent advances in the development of high strength materials, coupled with more advanced computational methods and design procedures, have led to a new generation of tall and slender buildings. These structures are very sensitive to the most common dynamic loads; wind and earthquakes. The primary requirement for a successful design is to provide safety while taking into account serviceability requirements. This book provides a well-balanced and broad coverage of the information needed for the design of structural systems for wind- and earthquake-resistant buildings. It covers topics such as the basic concepts in structural dynamics and structural systems, the assessment of wind and earthquake loads acting on the system, the evaluation of the system response to such dynamic loads and the design for extreme loading. The text is generously illustrated and supported by numerical examples and will be of great interest to practising engineers and researchers in structural, civil and design engineering and also to architects. The author has drawn on his experience as a teacher, researcher and consultan
Antimicrobial susceptibility of coagulase negative Staphylococci isolates from suspected cases of bovine subclinical mastitis in parts of Bundelkhand region
No full textBackground: Increasing importance of Coagulase negative Staphylococci as etiological agent in health concerns of domestic animals is recognized in various studies. A significant concern of CoNS isolates from bovine subclinical mastitis is development of resistance towards antimicrobials routinely used in management diseases like mastitis. Isolates from study area had not been worked out properly in previous reports. Methodology: 125 Staphylococci sp. isolates identified in previous study by the authors were screened for resistance against 9 antimicrobials of common use using the Kirby Bauer disk diffusion method. Minimal inhibitory concentrations of 8 antibiotics were measured by using EzyTM Strips supplied by Himedia. Multiple drug resistance was also determined by analyzing results with individual antimicrobial agent. Results: Significant resistance towards β-lactam group of antibiotics penicillin and oxacillin was observed in isolates with 85.6 and 41.40 % respectively. Trimethoprim was second group of antibiotics for which isolates were found resistant with 81.60%. 20.8, 12, 10.40, 8.80, and 3.20% isolates were found resistant to erythomycin, tetracyclin, gentamycin, ciprofloxacin and ofloxacin respectively. Thus highest susceptibility was observed to fluoroquinolones. Data analysis also revealed multiple drug resistance in isolates as 44% of isolates was also found resistant to 3 or more antibiotics. On regional basis highest number of antibiotic resistant CoNS isolates was reported from Jhansi followed by Lalitpur and Jalaun. Conclusion: The study revealed the incidence of multiple antibiotic resistances in Coagulase negative Staphylococci isolates from possible cases of bovine subclinical mastitis and if not managed properly may be responsible for horizontal transfer of resistance from animal to man through food born infections
In Vitro studies on antibacterial activity and phytochemical analysis of whole plant extracts of Stelleria media
No full textThe whole plant extracts of Stelleria media were examined for the presence of alkaloids and phenolics with simultaneous study on the antimicrobial properties of these extracts. Investigation was carried out using four different concentration (62.5, 125, 250 and 500 mg/ml) of extract to determine the quantitative effectiveness. Preliminary evaluation of both the aqueous and the chloroform fractions showed a broad spectrum of activity ((p<0.05)) since the extracts inhibit the growth of both gram positive and gram negative bacterial isolates. Clinical isolates used in present investigation were E.coli, S.typhi, K. pneumonia, Staph. Aureus, Pseudomonas aeruginosa, Bacillus subtilis. The phytochemical analysis revealed the presence of alkaloids, saponins, tannins, flavonoids, cardiac glycosides, anthraquinones and cyanogenetic glycosides in varying concentration. Both the chloroform and aqueous extracts inhibited the growth of the test organisms with Salmonella typhi and E.coli showing the highest susceptibility but the pathogens were found to be less sensitive for chloroform extract in comparison to the aqueous extract which could be due to the domination of antimicrobial activity of water soluble polar compounds. This research supports the local use of the plant, Stelleria media for prophylactic and therapeutic purposes against bacterial infection
Fifty-one inguinal herniae repaired under local anaesthetic with excellent satisfaction ratings and low pain scores
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