1,281 research outputs found
Strategies to manage perishability in a perishable food supply chain
No full textPerishable food supply chains (PFSCs) have special challenges of short shelf life, strict time windows, product quality degradation issues, and product safety issues. With an estimated one-third of all food wasted in global food supply chains, managing perishability is a key concern for sustainability of PFSCs. The present chapter identifies key operational strategies to manage the PFSC. A mixed-methods approach was used based on systematic literature review (SLR) and bibliometric analysis. This chapter further considers the case study of a dairy food supply chain (DFSC) in India. Dairy industry serves as the ideal case of an industry that strategically uses supply chain drivers to manage perishability, resulting in a high-performance supply chain. The analysis showed that first-mile technology application, effective cold chain management, stakeholder management and strict temperature control are some of the key aspects of managing perishability in PFSC. While cold chain serves as the backbone of the dairy supply chain, integration of farmers and supply chain responsiveness are other important aspects of managing PFSC. Managing perishability is a key factor for achieving global food safety, security and sustainable development goals. This chapter contributes towards sustainable food supply chains through successful management of perishability
Microevolution of <i>Neisseria lactamica</i> during prolonged colonisation of the nasopharynx
No full textCarriage of Neisseria lactamica occurs naturally at high frequency in infants and low frequency in young adults. There is an inverse epidemiological relationship between N. lactamica carriage and disease caused by Neisseria meningitidis (meningococcus). Serogroup B meningococci remain the dominant cause of invasive meningococcal disease in the developed world and have frustrated the production of polysaccharide-conjugate vaccines. While two, recombinant, OMV based vaccines (Richmond et al., 2012; Vernikos and Medini, 2014) have been created and elicit immunological responses, they are less effective on infants (one of the groups most at risk of IMD) and have limited effect on meningococcal carriage and subsequently, on herd immunity. A human experimental challenge study in which healthy, young adult volunteers were inoculated with N. lactamica Y92-1009 showed that carriage of N. lactamica both displaced and inhibited reacquisition of wild type N. meningitidis, and although rare, co-colonization of the two species was also observed in a small number of cases (Deasy et al., 2015). This study provided the opportunity to investigate whether there is a genomic basis for N. lactamica’s effect on meningococcal carriage as the mechanism for this interaction remains unknown. Secondly, the use of whole genome sequencing, paired with mutation analysis via the breseq pipeline (Barrick et al., 2014) will comment on the mutability of N. lactamica, a potential bacterial medicine, during 6 months of in vivo, human challenge. Thirdly, this allows us to track the within-host microevolution of an identically administered commensal Neisseria spp. over the course of 6 months of carriage (chapter 5).Isolates obtained from individuals who were co-colonised by N. meningitidis and N. lactamica for a prolonged period were examined for evidence of the effect of recombination (r/m) as well as loci affected by it (chapter 6). In addition to the majority of volunteers who solo carried N. lactamica Y92-1009. Recombination was determined for; volunteers in which inoculated N. lactamica was the sole Neisseria spp. detected, seven, artificially inoculated, N. lactamica/meningococcal co-carriers and two extra volunteers who were naturally co-colonised. Using ClonalFrameML (Didelot and Wilson, 2015), we detected minimal homologous recombination events among N. lactamica Y92-1009 and no examples of interspecific allele transferred with co-colonising meningococci. In contrast, we found evidence of a dynamic, interspecific relationship and a number of recombination events occurring among co-colonised volunteers with naturally acquired Neisseria.A separate, short term clinical trial utilizing multiple colony sampling (chapter 4) examined the difference in mutational profiles of longitudinal samples N. lactamica strain Y92-1009 sourced from in vitro conditions versus in vivo conditions over one month. Larger numbers of SNPs, nonsense and recurring mutations were observed among the in vitro cohort and the quantity/diversity of phase variable mutations was more pronounced among the in vivo cohort. Chapters 4 and 5 are supported by a highly-accurate reference genome. The sequencing, assembly, annotation and characterisation of the first complete N. lactamica Y92-1009 genome is described in chapter 3 (Pandey et al., 2017). This chapter also revealed the presence of a large but uncharacterised prophage sequence in the strain. The very first example of a species encompassing, pan genomic analysis of N. lactamica (chapter 7) revealed that N. lactamica Y92-1009 possess fewer unique genes/alleles than other members of the species with no virulence factors detected among the results.In conclusion, the N. lactamica Y92-1009 genome is a self-curated system with plastic elements that (like other Neisseria spp.) could facilitate rapid changes in expression via its phase variable elements. However, it appears to have remained genetically stable during the 6-month course of carriage in human volunteers. Demonstrating little recombination, no interspecific gene transfer with co-colonising meningococci and an average mutation rate for a Neisseria species. While efforts need to be made to improve the acquisition and retention of carriage, N. lactamica appears to be a safe, naturally competent, potential bacterial therapeutic, capable of a broadspectrum reduction of meningococcal carriage.<br/
Listening to dark sirens from gravitational waves : Combined effects of fifth force, ultralight particle radiation, and eccentricity
No full textWe analyse the orbital period decay in compact binary systems influenced by a fifth force and ultralight particle radiation, considering a general eccentric Keplerian orbit. The analysis provides constraints on the axion decay constant when orbital period decay involves axionic fifth force and axion radiation. The bound on axion coupling improves by an order of magnitude for high eccentricity binaries like the Hulse–Taylor binary. These bounds become stronger when considering both axion mediation and radiation. We also derive constraints on the strengths of the fifth force and radiation from GW170817 by measuring the Chirp mass, which depends on initial eccentricity. The coalescence time increases with higher initial eccentricity compared to the gravity-only scenario, highlighting the importance of accurately selecting initial eccentricity for setting bounds on fifth force searches in precision gravitational wave detection. Additionally, we provide model-independent estimates for dark matter capture by a binary system. The derived constraints can be further strengthened with the use of second and third generation gravitational wave detectors
Supplemental Material, Figure_E2A-E2C - Bentall’s Procedure for Annuloaortic Ectasia and Severe Aortic Regurgitation in a Patient With Repaired Tetralogy of Fallot and Aortic Valvular Reconstruction
No full textSupplemental Material, Figure_E2A-E2C for Bentall’s Procedure for Annuloaortic Ectasia and Severe Aortic Regurgitation in a Patient With Repaired Tetralogy of Fallot and Aortic Valvular Reconstruction by Ujjwal Kumar Chowdhury, Niwin George, Vasubabu Gudala, Anish Gupta, Sheil Avneesh, Lakshmi Kumari Sankhyan, Vishwas Malik and Pramod Kumar in World Journal for Pediatric and Congenital Heart Surgery</p
Supplemental Material, Suppemental_Figure_legends_(1) - Bentall’s Procedure for Annuloaortic Ectasia and Severe Aortic Regurgitation in a Patient With Repaired Tetralogy of Fallot and Aortic Valvular Reconstruction
No full textSupplemental Material, Suppemental_Figure_legends_(1) for Bentall’s Procedure for Annuloaortic Ectasia and Severe Aortic Regurgitation in a Patient With Repaired Tetralogy of Fallot and Aortic Valvular Reconstruction by Ujjwal Kumar Chowdhury, Niwin George, Vasubabu Gudala, Anish Gupta, Sheil Avneesh, Lakshmi Kumari Sankhyan, Vishwas Malik and Pramod Kumar in World Journal for Pediatric and Congenital Heart Surgery</p
Supplemental Material, Figures_E1A-E1I - Bentall’s Procedure for Annuloaortic Ectasia and Severe Aortic Regurgitation in a Patient With Repaired Tetralogy of Fallot and Aortic Valvular Reconstruction
No full textSupplemental Material, Figures_E1A-E1I for Bentall’s Procedure for Annuloaortic Ectasia and Severe Aortic Regurgitation in a Patient With Repaired Tetralogy of Fallot and Aortic Valvular Reconstruction by Ujjwal Kumar Chowdhury, Niwin George, Vasubabu Gudala, Anish Gupta, Sheil Avneesh, Lakshmi Kumari Sankhyan, Vishwas Malik and Pramod Kumar in World Journal for Pediatric and Congenital Heart Surgery</p
Calling for Culpability: Anish Kapoor's Dirty Corner
Get PDFBeginning in 2008, The Château of Versailles has hosted temporary exhibitions by contemporary artists. This paper looks at the backlash incurred against the exhibition by British-Indian artist Anish Kapoor, specifically his sculpture Dirty Corner. After Dirty Corner was vandalized with antisemitic hate speech, the artist pushed back against removing the graffiti, which only compounded the already antagonistic relationship between Kapoor, Versailles, and the public.
This paper posits that Kapoor’s refusal to cleanse Dirty Corner of its anti-Semitic defacement confronts France’s lingering denial of responsibility in both the Holocaust during WWII, and the nation’s burgeoning xenophobia in the wake of the European Refugee Crisis.student peer reviewed journal articlefinal article publishe
Elastic stiffness and damping measurements in titanium alloys using atomic force acoustic microscopy
No full textAtomic force acoustic microscopy (AFAM) has been used to study the distribution of elastic stiffness and damping properties across different phases, such as alpha & beta phases in a beta titanium alloy (Ti-10V-4.5-Fe-1.5Al) and alpha, beta and alpha' phases in an alpha + beta alloy (Ti-6Al-4V). Contact-resonance spectra were obtained with a 100 nm spatial resolution in various specimens of the two titanium alloys heat-treated at different temperatures. The study indicates that the metastable beta phase has the minimum modulus and maximum damping followed by alpha' and alpha-phases. Employing the rule of mixtures, the average modulus measured by AFAM was then compared with the modulus obtained by ultrasonic velocity measurements. The error in the average modulus values obtained by both techniques is discussed. (C) 2016 Elsevier B.V. All rights reserved
A REVIEW ON THE STATE OF THE ART IN WIRE ELECTRIC DISCHARGE MACHINING (WEDM) PROCESS
No full textANISH KUMAR 1 Dr. VINOD KUMAR 2, Dr. JATINDER KUMAR
sj-docx-1-hol-10.1177_09596836241236347 – Supplemental material for A high-resolution record of Mid- to Late-Holocene environmental changes from a land-locked lake in Schirmacher Oasis, East Antarctica
No full textSupplemental material, sj-docx-1-hol-10.1177_09596836241236347 for A high-resolution record of Mid- to Late-Holocene environmental changes from a land-locked lake in Schirmacher Oasis, East Antarctica by GS Joju, Anish Kumar Warrier, BS Mahesh, AS Yamuna Sali, Cheryl A Noronha-D’Mello, K Balakrishna and Rahul Mohan in The Holocene</p
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