100 research outputs found
Subnational Determinants of Foreign Direct Investments in the Russian Federation
No full textOur purpose is to examine the determinants of subnational distribution of Foreign Direct Investments (FDI) in the key fifteen regions of Russia over the period of 2005-2011 using panel data. Within the most important economic regions of the country we found market seeking is still the main purpose of foreign inward investments. As a result, the size of the Russian consumer market presents a significant influence on the foreign economic activities alongside trade openness and government economic incentives. Our results from regression analysis indicate that gross regional product per capita, trade openness and the existence of special economic zones have significant positive impact on the regional distribution of FDI in the Russian Federation
Provenance-based trust for grid computing: Position Paper
No full textCurrent evolutions of Internet technology such as Web Services, ebXML, peer-to-peer and Grid computing all point to the development of large-scale open networks of diverse computing systems interacting with one another to perform tasks. Grid systems (and Web Services) are exemplary in this respect and are perhaps some of the first large-scale open computing systems to see widespread use - making them an important testing ground for problems in trust management which are likely to arise. From this perspective, today's grid architectures suffer from limitations, such as lack of a mechanism to trace results and lack of infrastructure to build up trust networks. These are important concerns in open grids, in which "community resources" are owned and managed by multiple stakeholders, and are dynamically organised in virtual organisations. Provenance enables users to trace how a particular result has been arrived at by identifying the individual services and the aggregation of services that produced such a particular output. Against this background, we present a research agenda to design, conceive and implement an industrial-strength open provenance architecture for grid systems. We motivate its use with three complex grid applications, namely aerospace engineering, organ transplant management and bioinformatics. Industrial-strength provenance support includes a scalable and secure architecture, an open proposal for standardising the protocols and data structures, a set of tools for configuring and using the provenance architecture, an open source reference implementation, and a deployment and validation in industrial context. The provision of such facilities will enrich grid capabilities by including new functionalities required for solving complex problems such as provenance data to provide complete audit trails of process execution and third-party analysis and auditing. As a result, we anticipate that a larger uptake of grid technology is likely to occur, since unprecedented possibilities will be offered to users and will give them a competitive edge
Economics of dry land agriculture in Maharashtra with particular reference to Mandrup Project, District Sholapur
No full textBibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
Get PDFThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
Entrance length of suspension pipe flows - An experimental study
No full textParticle-laden pipe flows are ubiquitous in industrial applications. Examples are industries like dredging, slurry transport, and the transport of reactants and products in chemical industries. One of the most important factors in these transport processes is the friction coefficient which relates directly to the pumping power which is a significant parameter for industries when viewed from an economic standpoint. The migration of particles in dense suspensions can significantly impact the friction coefficient in pipe flow. The clustering of particles in the core can lead to a reduction in the friction factor compared to a well-mixed particle suspension. This reduction is attributed to the decreased effective viscosity near the pipe wall. While the development lengths of single-phase flows are well known, limited knowledge exists regarding the development of velocity and concentration profiles in suspension flows.The goal of this thesis is to study the development of neutrally buoyant suspension pipe flows. The experimental setup was validated using pressure drop measurements and the entrance length for single-phase pipe flow was obtained. The experiments for suspension flows involved varying the suspension Reynolds number and volume fractions keeping the particle size constant. Ultrasound imaging technique is used to circumvent the opacity of the suspension to study the development of suspension pipe flow. The inlet conditions for concentration were characterized, obtaining a uniform distribution at the inlet. Measurements are conducted at various locations downstream of the pipe and the velocity of the dispersed phase is obtained using ultrasound imaging velocimetry. Additionally, insights into the development of the concentration profile are obtained by checking the convergence towards a fully developed intensity profile, despite the fact that the image intensity doesn’t directly correlate to concentration profiles. The velocity profiles and intensity profiles were analyzed to understand the effect of radial migration on both concentration and velocity profiles. The entrance lengths for concentration and velocity were obtained for volume fractions ranging from 0.17 to 0.25 and suspension Reynolds numbers ranging from 500-2000. The results obtained revealed that the entrance length for concentration was greater than the entrance length for velocity. Scaling of the concentration entrance length with suspension Reynolds number and volume fractions were determined, and suspension Reynolds number scaled with an exponent of -1.62 and volume fraction scaled with an exponent of -2.1. This implies that the entrance length decreases with an increase in suspension Reynolds number and volume fraction. However, no definite trend was observed for the velocity entrance length.Mechanical Engineerin
Analytical study of contents of LANL physics and cross-listed e-print archives, 1994-2002
No full textThe frontiers of physics and cross-listed e-print archives posted during the years 1994-2002 at http://www.arxiv.org/archives/physics web service of Los Alamos National Laboratory (LANL) are explored from 7770 submissions. E-print archives posted to top most six physics-cross-listed research categories besides physics (5390) are: Condensed matter (754), Quantum physics (279), Astrophysics (222), Chemical physics (129), High energy physics - Phenomenology (118), and High energy physics-Theory (100). Prominent contributors are B.G. Sidharth (India), V.V. Flambaum (Australia), Antonina N. Fedorova (Russia), and Michael G. Zeitlin (Russia). Most preferred journals for rechannelising e-print archives are Physical Review Letters, Physical Review A, Physical Review E, Nuclear Instruments and Methods A, and Journal of Chemical Physics
Genomics as a tool for natural product structure elucidation
Get PDFNatural product discovery is in the midst of a transition from a largely serendipity-based effort to an informatics-driven one. For most of the 20th century, natural product discovery relied on genome-blind bioassay-guided isolation. This was initially exceptionally productive, yielding the golden age of antibiotics. The fact that a majority of all medicines—especially antibiotics—are in some way derived from or inspired by natural products is a testament to the importance of understanding and harnessing the chemical strategies for biological interaction that have evolved over millions of years. Unfortunately, the overwhelmingly frequent rediscovery rate of known compounds among screened natural extracts meant that what was initially a life-saving torrent of new drugs eventually dried up into a costly trickle. Unfortunately, this has coincided with the rise of drug-resistance superbugs as our initial stockpiles of antibiotics have become overdeployed.
Fortunately, we are now poised to enact an antibiotic renaissance powered by the ease and affordability of large-scale genomic analysis. The ability to genome-gaze has not only revealed hundreds of thousands of yet-untapped secondary metabolites in sequenced organisms but also can facilitate strain prioritization, novelty determination (dereplication), structure elucidation, three principal bottlenecks in the discovery process, as reviewed in Chapter 1. We report here progress in the use of genomics to facilitate the discovery and contextualization of new chemical matter.
In Chapter 2, we report the discovery, isolation, and structural elucidation of streptomonomicin (STM), an antibiotic lasso peptide from Streptomonospora alba, and report the genome for its producing organism. STM-resistant clones of Bacillus anthracis harbor mutations to walR, the gene encoding a response regulator for the only known widely-distributed and essential two-component signal transduction system in Firmicutes. Our results demonstrate that understudied microbes remain fruitful reservoirs for the rapid discovery of novel, bioactive natural product and also highlight the usefulness of genomics in combination with NMR and HR-MS/MS for determining the structure of ribosomal natural products.
In Chapter 3, we use HR-MS/MS, reactivity-based screening, NMR, and bioinformatic analysis to identify Streptomyces varsoviensis as a novel producer of JBIR-100, a fumarate-containing hygrolide. Using a combination of NMR and bioinformatic analysis, we elucidated the stereochemistry of the natural product. We investigated the antimicrobial activity of JBIR-100, with preliminary insight into mode of action indicating that it perturbs the membrane of Bacillus subtilis. S. varsoviensis is known to produce compounds from multiple hygrolide sub-families, namely hygrobafilomycins (JBIR-100 and hygrobafilomycin) and bafilomycins (bafilomycin C1 and D). In light of this, we identified the biosynthetic gene cluster for JBIR-100, which, to our knowledge, represents the first reported for a hygrobafilomycin. Finally, we performed a bioinformatic analysis of the hygrolide family using our RODEO algorithm from Chapter 4, describing clusters from known and predicted producers. Our results indicate that potential remains for the Actinobacteria to yield novel hygrolide congeners and provides a survey of the hygrolide landscape.
In Chapter 4, we report RODEO (Rapid ORF Description and Evaluation Online), an algorithm which combines hidden Markov model-based analysis, heuristic scoring, and machine learning to identify biosynthetic gene clusters and predict RiPP precursor peptides. We initially focused on lasso peptides, which display intriguing physiochemical properties and bioactivities, but their hypervariability renders them challenging prospects for automated mining. Our approach yielded the most comprehensive mapping of lasso peptide space, revealing >1,300 compounds. We characterized the structures and bioactivities of six lasso peptides, prioritized based on predicted structural novelty, including an unprecedented handcuff-like topology and another with a citrulline modification exceptionally rare among bacteria. These combined insights significantly expand the knowledge of lasso peptides, and more broadly, provide a framework for future high-throughput genome mining. In addition to lasso peptides, RODEO provides the ability to analyze local genomic regions using custom profile hidden Markov models (pHMMs) and is suitable for RiPP, polyketide (PKS), nonribosomal peptide (NRPS), and other natural product biosynthetic gene cluster types; as part of an effort to make it available as a community resource we have created a web portal with its code and tutorials.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2018-12-01The student, Jonathan Tietz, accepted the attached license on 2016-11-28 at 16:51.The student, Jonathan Tietz, submitted this Dissertation for approval on 2016-11-28 at 17:01.This Dissertation was approved for publication on 2016-11-29 at 13:08.DSpace SAF Submission Ingestion Package generated from Vireo submission #10341 on 2017-02-28 at 14:42:14Made available in DSpace on 2017-03-01T17:01:41Z (GMT). No. of bitstreams: 2
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Scientometric portrait of Ram Gopal Rastogi
Get PDFPublication productivity of Indian scientist (R.G. Rastogi) has been documented.
Scientometric analysis of 312 papers by Ram Gopal Rastogi published during 1954 to 1992 in various domains: (a) Luni -solar activity and quiet -time E & F- region (57); (b) Equatorial electric field and low and mid latitude iof:osphere (78); (c) Ionospheric E- region irregularities (19); (dj Ionospheric F- region irregularities (32); and (e) Magnetic disturbance effects on the equatorial low and mid latitude ionosphere (23) were analysed. Interdomainery contents and of the number of papers: a+b were 36; b+c and b+d were 20 each; b+e were 16;. c+e were 5; a+e were 3; d+e were 2; and a+d had only one publication. Highest collaborations were with H. Chandra (61), M.R. Deshpande (42), and G. Sethia (19) out of his total 97 collaborators. His highest productivity was during 1978 with 28 papers followed by 19 papers during 1977. The core journals preferred by him for publishing papers were: Indian Journal of Radio & Space Physics, India, and Journal of Atomic & Terrestrial Physics, UK (59 each), followed by Proceedings of the Indian Academy of Sciences, India (34). Most prolific title keywords with their frequencies were: Ionosphere (92); Equatorial (61); F-region (53); Equatorial electrojet region (40), and Magnetic equator (30)
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