1,720,977 research outputs found
Estimation of insulin sensitivity from CGM and subcutaneous insulin delivery in type 1 diabetes
No full textThe aim of this work is to build a method that estimates insulin sensitivity from CGM signal and insulin pump delivered in patients with type 1 diabetes in normal daily life conditions, that can be easily implemented in a portable device like CGM systems. Starting from CGM and insulin infusion data, and using subject-specific parameters which are approximated using field-measurable subject characteristics, this invention estimates, for each meal, the insulin sensitivity of the patient by using simple algebra formulas. This invention can potentially be implemented in portable advisory systems on an artificial pancreas architecture, already composed by necessary devices to evaluate this parameter, thus improving the control therapy, by registering insulin sensitivity pattern during the day
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Closed-loop artificial pancreas systems: Physiological input to enhance next-generation devices
No full textTo provide an understanding of both the preclinical and clinical aspects of closed-loop artificial pancreas systems, we provide a discussion of this topic as part of this two-part Bench to Clinic narrative. Here, the Bench narrative provides an in-depth understanding of insulin-glucose-glucagon physiology in conditions that mimic the free-living situation to the extent possible in type 1 diabetes that will help refine and improve future closed-loop system algorithms. In the Clinic narrative, Doyle and colleagues compare and evaluate technology used in current closed-loop studies to gain further momentum toward outpatient trials and eventual approval for widespread use
Daily pattern of insulin sensitivity enables optimization of insulin to carbohydrate ratio: first results from the STAR 3 study
No full textA New Index of Insulin Sensitivity from Minimally-Invasive Technologies in Type-1 Diabetes
No full textModeling the Effect of Physical Activity on Postprandial Glucose Turnover in Healthy Subjects
No full textAssessment of diurnal variations of insulin sensitivity, beta cell responsivity and hepatic insulin extraction in normal subjects
No full textAssessment of Postprandial Glucose Turnover in Presence of Moderate Physical Activity using a Stochastic Deconvolution Method
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