1,401 research outputs found
Teaching HW/SW Co-Design With a Public Key Cryptography Application
No full textThis paper describes a lab session-based course on hardware/software (HW/SW) co-design. Real problems often need to combine the speed of an HW solution with the flexibility of an SW solution. The goals of this course are to show that there are many alternative solutions in the design space and to teach the fundamental concepts of HW/SW co-design. The sample application for the course project is a basic public key (RSA) application. This application is attractive for pedagogic purposes because its complex arithmetic and large word lengths make it difficult to realize in SW on an embedded microcontroller. However, the alternative of a pure application-specific integrated circuit (ASIC) application is also not a satisfactory solution, as this lacks the flexibility to support multiple public key applications. The project follows a stepwise approach, with assignments that build on each other. Students are required to make their own decisions as to the partitioning between HW and SW, the interface design, and the optimizations goals. Besides imparting hard skills in HW design and embedded SW design, the course inculcates several soft skills - in particular, decision making, presentation skills, teamwork, and design creativity - generally overlooked in engineering. © 2013 IEEE.sponsorship: This work was supported in part by the Research Council KU Leuven: GOA TENSE (GOA/11/007) and the Flemish iMinds projects, and also supported by the Flemish Government, FWO G.0550.12N, the Hercules Foundation AKUL/11/19, and the Intel University Program. (Research Council KU Leuven: GOA TENSE|GOA/11/007, Flemish iMinds projects, Flemish Government, FWO|G.0550.12N, Hercules Foundation|AKUL/11/19, Intel University Program)status: Publishe
Kualitas Layanan Terhadap Kepuasan Siswa Pada Akademi HW Temanggung dan Akademi Persopi Elang Timur Bantul
Full text linkPenelitian ini bertujuan untuk : (1) mengetahui kualitas layanan di Akademi HW Temanggung, (2) mengetahui kualitas layanan di Akademi Persopi Elang Timur Bantul.
Penelitian ini adalah penelitian deskriptif. Metode yang digunakan dalam penelitian ini adalah survei dengan teknik pengumpulan data menggunakan angket tertutup. Populasi dalam penelitian ini adalah 127 siswa Akademi HW Temanggung dan 80 siswa Akademi Persopi Elang Timur Bantul. Teknik pengambilan sampel menggunakan purposive sampling dengan kriteria (1) siswa aktif usia 13-17 tahun (KU 2007-2011) di Akademi HW Temanggung dan Akademi Persopi Elang Timur Bantul, (2) tergabung sebagai siswa Akademi HW Temanggung dan Akademi Persopi Elang Timur. Berdasarkan kriteria tersebut yang memenuhi berjumlah 20 siswa dari Akademi HW
Temanggung dan 20 siswa Akademi Persopi Elang Timur Bantul. Teknik analisis data menggunakan deskriptif kuantitatif yang dituangkan dalam bentuk persentase.
Hasil penelitian ini menunjukkan bahwa kualitas layanan terhadap kepuasan siswa yang ditinjau dari lima faktor yaitu Tangible, Emphaty, Reliability, Responsiveness, dan Assurance. Akademi HW Temanggung diperoleh tingkat kualitas layanan terhadap kepuasan siswa yang ditinjau dari lima faktor yaitu dengan kategori “sangat kurang memuaskan” sebesar 0%, “kurang memuaskan” sebesar 40%, “cukup memuaskan” sebesar 30%, “memuaskan” sebesar 20%, dan “sangat memuaskan” sebesar 10%. Sedangkan Akademi Persopi Elang Timur Bantul diperoleh tingkat kualitas layanan
terhadap kepuasan siswa yang ditinjau dari lima faktor yaitu dengan kategori “sangat kurang memuaskan” sebesar 10%, “kurang memuaskan” sebesar 15%, “cukup memuaskan” sebesar 40%, “memuaskan” sebesar 35%, dan “sangat memuaskan” sebesar 0%
Gluon fusion and bb¯ corrections to HW+W−/HZZ production in the POWHEG-BOX
No full textAbstractThe study of the Higgs boson properties is one of the most important tasks to be accomplished in the next years, at the Large Hadron Collider (LHC) and at future colliders such as the Future Circular Collider in hadron–hadron mode (FCC-hh), the potential 100 TeV follow-up of the LHC machine. In this view the precise study of the Higgs couplings to weak gauge bosons is crucial and requires as much information as possible. After the recent calculation of the next-to-leading order QCD corrections to the production cross sections and differential distributions of a Standard Model Higgs boson in association with a pair of weak bosons, matched with parton shower in the POWHEG-BOX framework, we present the gluon fusion correction gg→HW+W−(HZZ) to the process pp→HW+W−(HZZ). This correction can be sizeable and amounts to +3% (+10%) in the HW+W− process and +5% (+18%) in the HZZ process at the LHC (FCC-hh). We also present the first study of the impact of the bottom-quark initiated channels bb¯→HW+W−/HZZ and find that they induce a significant +18% correction in the HW+W− channel at the FCC-hh. We present results on total cross sections and distributions at the LHC and at the FCC-hh
KrakenOnMem: A Memristor-Augmented HW/SW Framework for Taxonomic Profiling
No full textState-of-the-art taxonomic profilers that comprise the first step in larger-context metagenomic studies have proven to be computationally intensive, i.e., while accurate, they come at the cost of high latency and energy consumption. Table Lookup operation is a primary bottleneck of today's profilers. In this paper, we first propose TL-PIM, a hardware accelerator based on the processing-in-memory (PIM) paradigm to accelerate Table Lookup. TL-PIM leverages the in-memory compute capability of emerging memory technologies along with intelligent data mapping. Then, we integrate TL-PIM into Kraken2, a state-of-the-art metagenomic profiler, and build an HW/SW co-designed profiler, called KrakenOnMem. Results from a silicon-based prototype of our emerging memory validate the design and required operations on a smaller scale. Our large-scale calibrated simulations show that KrakenOnMem can provide an average of 61.3% speedup compared to original Kraken2 for end-to-end profiling. Additionally, our design improves the energy consumption by orders of magnitude compared to the original Kraken2 while incurring a negligible area overhead. Computer EngineeringElectrical Engineering, Mathematics and Computer ScienceQuantum & Computer Engineerin
The Insulator Protein SU(HW) Fine-Tunes Nuclear Lamina Interactions of the Drosophila Genome
No full textSpecific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in the human genome, and suggested that the insulator protein CTCF may help to demarcate these domains. Here, we report the detailed structure of LADs in Drosophila cells, and investigate the putative roles of five insulator proteins in LAD organization. We found that the Drosophila genome is also organized in discrete LADs, which are about five times smaller than human LADs but contain on average a similar number of genes. Systematic comparison to new and published insulator binding maps shows that only SU(HW) binds preferentially at LAD borders and at specific positions inside LADs, while GAF, CTCF, BEAF-32 and DWG are mostly absent from these regions. By knockdown and overexpression studies we demonstrate that SU(HW) weakens genome – NL interactions through a local antagonistic effect, but we did not obtain evidence that it is essential for border formation. Our results provide insights into the evolution of LAD organization and identify SU(HW) as a fine-tuner of genome – NL interactions.BiotechnologyApplied Science
Understanding a time reversal process in Lamb wave propagation
No full textThis study investigates the time reversal process (TRP) of Lamb wave signals which are transmitted and received by piezoelectric transducers bonded on plate-like structures. A number of previous studies have paid attention to spatial and temporal refocusing capability of an original excitation through the TRP in highly dispersive and complex media. However, when the TRP is applied to Lamb waves in a homogeneous regular waveguide, the refocusing capability is limited due to permanent residual side bands even if the duration of the time reversed signal increases. Based on the reciprocity of elastodynamics and linear piezoelectricity, theoretical interpretation is conducted for the main and residual side bands of the reconstructed signal in the time domain. In particular, the interpretation includes the temporal effect of velocity and amplitude dispersions, the existence of multi-modes, and the reflections from boundaries during the TRP. Then, numerical and experimental tests are conducted to validate the theoretical findings of this paper. Practical issues for the successful implementation of the TRP of Lamb waves are briefly addressed as well. (C) 2009 Elsevier B.V. All rights reserved.This work was supported by Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research
Promotion Fund) (KRF-2008-331-D00590), in which main calculations were performed by using the supercomputing
resource of the Korea Institute of Science and Technology Information (KISTI), and the Radiation Technology Program under
Korea Science and Engineering Foundation (KOSEF) and the Ministry of Science and Technology (M20703000015-07N0300-
01510). The second author would like to acknowledge the graduate fellowship program from Samsung Scholarship in Seoul,
Korea
Wave-front Behaviour of the Pulsed EM Field – Complexity and Implications
No full textThe pulsed electromagnetic (EM) field radiated by a gap-fed, long slot in a perfectly conducting thin sheet located in between dielectric and free-space subdomains is examined. A phenomenological interpretation of the so-called head wave (HW) constituent is proposed, this fostering the understanding of the complex EM behaviour at, and immediately behind, the HW wave-front. The EM field is also examined numerically for identifying features that may lead the way towards inferring a causal counterpart of the leaky-wave propagation.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Tera-Hertz SensingElectrical Engineering Educatio
Extended pancreas donor program - the EXPAND study rationale and study protocol
Full text linkBACKGROUND:
Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenile) diabetes mellitus with or without impaired renal function. Unfortunately, transplant waiting lists for this indication are increasing because the current organ acceptability criteria are restrictive; morbidity and mortality significantly increase with time on the waitlist. Currently, only pancreas organs from donors younger than 50 years of age and with a body mass index (BMI) less than 30 are allocated for transplantation in the Eurotransplant (ET) area. To address this issue we designed a study to increase the available donor pool for these patients.
METHODS/DESIGN:
This study is a prospective, multicenter (20 German centers), single blinded, non-randomized, two armed trial comparing outcome after SPK, PTA or PAK between organs with the currently allowed donor criteria versus selected organs from donors with extended criteria. Extended donor criteria are defined as organs procured from donors with a BMI of 30 to 34 or a donor age between 50 and 60 years. Immunosuppression is generally standardized using induction therapy with Myfortic, tacrolimus and low dose steroids. In principle, all patients on the waitlist for primary SPK, PTA or PAK are eligible for the clinical trial when they consent to possibly receiving an extended donor criteria organ. Patients receiving an organ meeting the current standard criteria for pancreas allocation (control arm) are compared to those receiving extended criteria organ (study arm); patients are blinded for a follow-up period of one year. The combined primary endpoint is survival of the pancreas allograft and pancreas allograft function after three months, as an early relevant outcome parameter for pancreas transplantation.
DISCUSSION:
The EXPAND Study has been initiated to investigate the hypothesis that locally allocated extended criteria organs can be transplanted with similar results compared to the currently allowed standard ET organ allocation. If our study shows a favorable comparison to standard organ allocation criteria, the morbidity and mortality for patients waiting for transplantation could be reduced in the future.
TRIAL REGISTRATION:
Trial registered at: NCT0138400
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.
Full text linkMalaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality control in 227 samples from Africa, Asia and Oceania provides genome-wide estimates of allele frequency distribution, population structure and linkage disequilibrium. By comparing the genetic diversity of individual infections with that of the local parasite population, we derive a metric of within-host diversity that is related to the level of inbreeding in the population. An open-access web application has been established for the exploration of regional differences in allele frequency and of highly differentiated loci in the P. falciparum genome
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