196,319 research outputs found
Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C-H insertion
No full textAbstract not availableNiels Krogsgaard-Larsen, Mikael Begtrup, Karla Frydenvang, Jan Kehle
Novel, versatile three-step synthesis of 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles by intramolecular carbene-mediated C-H insertion
No full textA new convenient three-step synthesis of the privileged CNS scaffold 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles has been developed. The method makes use of an intramolecular carbene-mediated C-H insertion in phenylpiperazine-derived tosylhydrazones made from 2-fluorobenzaldehydes. Notably, the piperazine can be replaced with other cyclic nitrogen bases and the methodology is successfully extended to pyrrolidine, piperidine, azepane, morpholine, and homopiperazine.Niels Krogsgaard-Larsen, Mikael Begtrup, Matthias M. Herth, Jan Kehle
ANALOGS OF THE LOW-EFFICACY PARTIAL GABA-A AGONIST 4-PIOL - SYNTHESES AND INVITRO PHARMACOLOGICAL STUDIES
No full text4-PIOL (3-hydroxy-5-(4-piperidyl)isoxazole) is a low-efficacy GABA(A)
agonist showing a dominating GABA(A) antagonist profile. Three dihydro
analogues of 4-PIOL were synthesized, including
(RS)-3-hydroxy-5-(4-piperidyl)-2-isoxazoline (1). The synthesis of 1
was based on a regioselective 1,3-dipolar cyclo-addition reaction
between 1-benzyloxycarbonyl-4-vinylpiperidine (7) and bromonitrile
oxide, prepared in situ from dibromoformoxime. Furthermore, the spiro
analogues of 1 3-hydroxy-1-oxa-2,8-diazaspiro{[4.5]dec-2-ene (2) and
(RS)-3-hydroxy-1-oxa-2,7-diazaspiro[4.5]dec-2-ene (3) were were
synthesized regiospecifically via cycloaddition of bromonitrile oxide to
the N-benzyloxycarbonyl-protected forms of 4-methylenepiperidine (11)
and 3-methylenepiperidine (15), respectively. In contrast to 4-PIOL,
none of the new compounds 1-3 showed detectable effects on the binding
of H-3-GABA(A) or the subunit-selective GABA(A) agonist, H-3-THIP, to
GABA(A) receptor sites, and they did not significantly affect the
muscimol-stimulated binding of H-3-diazepam to the benzodiazepine site
of the GABA(A) receptor complex.
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Use of patient-specific musuloskeletal models to relate subjective and objective outcome scores of acl injured patients
No full textPatient reported outcome measures (PROMs) often greatly improve after ACL reconstruction while biomechanical factors remain similar between the deficient and reconstructed states [1]. This suggests a discrepancy between the two approaches and how they describe a patient’s knee joint function. This discrepancy could be due the superficial nature of the chosen objective measures and that deeper, higher-level measures obtained through musculoskeletal modelling could consolidate subjective and objective scores to a greater degree. To do so requires patient-specific knee joint models and highly accurate tibiofemoral kinematics, previously only obtainable with invasive methods. We therefore developed a ptatient-specific MRI-based knee joint contact model to addres these limitations. The purpose of this study was to apply our novel methods to determine if knee ligament and joint contact forces during a hopping task were correlated to subjective functional scores
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
Get PDFFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Relationship of Knee Forces to Subjective Function Pre- and Post-ACL Reconstruction
No full textPURPOSE: Although basic objective measures (e.g., knee laxity, strength, and hop tests) have been related to subjective measures of function, associations between knee-specific objective and subjective measures have yet to be completed. The objective was to determine if knee joint contact and ligament forces differ between pre- and post-anterior cruciate ligament (ACL) reconstructed states and if these forces relate to their patient's respective subjective functional ability scores. METHODS: Twelve patients performed a hopping task before and after reconstruction. Magnetic resonance images and OpenSim were used to develop patient-specific models in static optimization and joint reaction analyses. Questionnaires concerning each patient's subjective functional ability were also collected and correlated with knee joint contact and ligament forces. RESULTS: No significant differences were observed between deficient and reconstructed groups with respect to knee joint contact or ligament forces. Nevertheless, there were several significant (P < 0.05) moderate to strong correlations between subjective and objective measures including Tegner activity level to contact force in both states (r = 0.67-0.76) and International Knee Documentation Committee to compressive and anterior shear forces (r = 0.64-0.66). CONCLUSION: Knee-specific objective measures of a patient's functional capacity can represent their subjective ability, which explains this relationship to a greater extent than past anatomical and gross objective measures of function. This consolidation is imperative for improving the current rehabilitation schema as it allows for external validation of objective and subjective functional measures. With poor validation of subjective function against objective measures of function, the reinjury rate is unlikely to diminish, continuing the heavy financial burden on health care systems
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