774 research outputs found
Shifting waterscapes: explaining basin closure in the Lower Krishna Basin, South India
No full textRiver basins / Ecosystems / Protective irrigation / Irrigation programs / Water transfer / Water distribution / Water allocation / Groundwater depletion / Aquifers / Water scarcity / Water use / Drought / India / Lower Krishna Basin / Godavari Basin / Nagarjuna Sagar Project / Kolleru Lake
The lower Krishna Basin trajectory: relationships between basin development and downstream environmental degradation
No full textRiver basin development / Lakes / Environmental degradation / Ecosystems / Mangroves / Water allocation / Groundwater / Water quality / Salinity / Irrigated farming / Institutions / Irrigation canals / Rural development
The Post Office Horizon system and Seema Misra
No full textThe author highlights the significance of the Seema Misra case in raising questions about the reliablity of the Post Office Horizon system and more widely suggesting that all digital systems have the possibility of latent defects, and these can never be discounted. He argues that when the efficacy of digital systems is called into question in legal proceedings, the onus of proof must be placed on the supplier of these systems and not the accuser.Index words: Post Office; Horizon; prosecutions; software errors; disclosure Full transcript of the trial Regina v Seema Misra, T2009007 (England & Wales; theft; electronic evidence; Post Office Horizon System; ‘reliability’ of computers) with case commentary and index to original papers held in the Documents Supplement of Volume 12: 2015
Multicriteria redundancy optimization using an efficient search procedure
No full textAn efficient approach to multiple criteria redundancy optimization problem, often encountered in reliability design of engineering systems, is presented. A search technique introduced earlier (Misra 1991) in combination with multicriteria optimization methods, based on the min-max concept for finding the Pareto optimal solution of multicriteria optimization problems, provides an efficient and excellent approach for solving redundancy optimization problems. The approach is illustrated through several numerical examples. Based on this approach, a very general computer code called efficient search multi-objective programming (ESMOP) has also been developed. It is capable of considering any type of redundancy, constraint or individual cost function and thus offers a solution to many reliability design problems
Erratum: Myocardial ischaemia and valve insufficiency caused by a dysplastic aortic valve cusp: A previously unreported unique morphologic anomaly (Cardiology in the Young (2020) (1-4) DOI: 10.1017/S1047951120001377)
No full text© The Author(s), 2020. The authors apologise that upon publication of this case report an author was left off. The online version of this article has been updated to list the authors correctly. Sharmeen Samuel, Preeta Dhanantwari, Nilanjana Misra, and David B. Meyer
Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase
No full textCitation: Ye, Z., Needham, P. G., Estabrooks, S. K., Whitaker, S. K., Garcia, B. L., Misra, S., . . . Camacho, C. J. (2017). Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Scientific Reports, 7(1). doi:10.1038/s41598-017-01880-4C-terminus of Hsc/p70-Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase.Each CHIP monomer consists of a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain.In contrast to nearly all homodimeric proteins, CHIP is asymmetric.To uncover the origins of asymmetry, we performed molecular dynamics simulations of dimer assembly.We determined that a CHIP monomer is most stable when the HH domain has an extended helix that supports intra-monomer TPR-U-box interaction, blocking the E2-binding surface of the U-box.We also discovered that monomers first dimerize symmetrically through their HH domains, which then triggers U-box dimerization.This brings the extended helices into close proximity, including a repulsive stretch of positively charged residues.Unable to smoothly unwind, this conflict bends the helices until the helix of one protomer breaks to relieve the repulsion.The abrupt snapping of the helix forces the C-terminal residues of the other protomer to disrupt that protomer's TPR-U-box tight binding interface, swiftly exposing and activating one of the E2 binding sites.Mutagenesis and biochemical experiments confirm that C-terminal residues are necessary both to maintain CHIP stability and function.This novel mechanism indicates how a ubiquitin ligase maintains an inactive monomeric form that rapidly activates only after asymmetric assembly. © 2017 The Author(s)
Parallel session 9 : Institutional management
No full textPresented Titles: Living in Uncertainty: The COVID-19 Pandemic and Higher Education in Hong Kong [Authors: Jisun Jung; Hugo Horta; Gerard A. Postiglione] Internalisation of China’s Higher Education and It’s Development Model [Author: Rochester Lima] Unprepared Cost of Survival: Revisiting Academic Returnees’ Cross-border Capital and Cultural Adaptation in Shanghai Universities [Authors: Jiaxin Chen; Xiaoxin Du] Us and Them: How Regions Shape the Boundaries of Elite Higher Education? [Author: Debananda Misra
Supporting Cyber-Physical Systems with Wireless Sensor Networks: An Outlook of Software and Services
No full textSensing, communication, computation and control technologies are the essential building blocks of a cyber-physical system (CPS). Wireless sensor networks (WSNs) are a way to support CPS as they provide fine-grained spatial-temporal sensing, communication and computation at a low premium of cost and power. In this article, we explore the fundamental concepts guiding the design and implementation of WSNs. We report the latest developments in WSN software and services for meeting existing requirements and newer demands; particularly in the areas of: operating system, simulator and emulator, programming abstraction, virtualization, IP-based communication and security, time and location, and network monitoring and management. We also reflect on the ongoing
efforts in providing dependable assurances for WSN-driven CPS. Finally, we report on its applicability with a case-study on smart buildings
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Towards Sustainable Operations Management Integrating Sustainability Management into Operations Management Strategies and Practices
No full text‘Sustainability’ is an increasingly relevant issue for a wide range of organisations, and therefore ‘sustainability management’ strategies and practices are of growing significance. Because many sustainability impacts are strongly influenced by operations management decisions it is critical that the operations management function embraces the requirements of sustainability management. This has implications for decisions and processes associated with all aspects of operations management including strategy, design, planning and control, and improvement. For example, appropriate environmental and social performance objectives, targets and indicators need to be integrated with quality, cost and other more conventional performance measures. The closed loop supply chain perspective must be adopted and the requirements of other stakeholders in addition to the customer must drive operations decisions. The scope of any given ‘operation’ is thereby expanded considerably and the nature of the operations management role altered, with implications both for the professional development of managers and the research needed to support the manager in this changed role
Nītilatāṅkura = Nitilatankur : a treatise on politics and warfare / compiled by Bagis Sarma ; editor Sarat Chandra Goswami ; assistant editor Joy Krishna Misra
No full textapplication/pdfapplication/pdf1st ed.Assamese and English, with some quotations in Sanskrit (Assamese script
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