1,924 research outputs found
Impaired revascularization in a mouse model of type 2 diabetes is associated with dysregulation of a complex angiogenic-regulatory network.
No full textOBJECTIVE:
Diabetes is a risk factor for the development of cardiovascular diseases associated with impaired angiogenesis or increased endothelial cell apoptosis.
METHODS AND RESULTS:
Here it is shown that angiogenic repair of ischemic hindlimbs was impaired in Lepr(db/db) mice, a leptin receptor-deficient model of diabetes, compared with wild-type (WT) C57BL/6 mice, as evaluated by laser Doppler flow and capillary density analyses. To identify molecular targets associated with this disease process, hindlimb cDNA expression profiles were created from adductor muscle of Lepr(db/db) and WT mice before and after hindlimb ischemia using Affymetrix GeneChip Mouse Expression Set microarrays. The expression patterns of numerous angiogenesis-related proteins were altered in Lepr(db/db) versus WT mice after ischemic injury. These transcripts included neuropilin-1, vascular endothelial growth factor-A, placental growth factor, elastin, and matrix metalloproteinases implicated in blood vessel growth and maintenance of vessel wall integrity.
CONCLUSIONS:
These data illustrate that impaired ischemia-induced neovascularization in type 2 diabetes is associated with the dysregulation of a complex angiogenesis-regulatory network
Generating topological order from a two-dimensional cluster state using a duality mapping
No full textIn this paper, we prove, extend and review possible mappings between the two-dimensional (2D) cluster state, Wen's model, the 2D Ising chain and Kitaev's toric code model. We introduce a 2D duality transformation to map the 2D lattice cluster state into the topologically ordered Wen model. Then, we investigate how this mapping could be achieved physically, which allows us to discuss the rate at which a topologically ordered system can be achieved. Next, using a lattice fermionization method, Wen's model is mapped into a series of 1D Ising interactions. Considering the boundary terms with this mapping then reveals how the Ising chains interact with one another. The duality of these models can be taken as a starting point to address questions as to how their gate operations in different quantum computational models can be related to each other. © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft
Oregon serious crime survey
No full textauthor, survey administration and data processing: Stan WoodwellCaption titleThis archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposesBureau of Justice Statistics, United States Department of Justice 80-BJ-CX-K009 82-BJ-CX-0002 82-BJ-CX-0014Mode of access: Internet from the Oregon Government Publications CollectionText in Englis
BJ-TSA-9, a Novel Human Tumor-Specific Gene, Has Potential as a Biomarker of Lung Cancer
No full textAbstractUsing bioinformatics, we have identified a novel tumorspecific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcriptionpolymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (68.8%). To explore the potential application of BJ-TSA-9 for the detection of circulating cancer cells in lung cancer patients, nested RT-PCR was performed. The overall positive detection rate was 34.3% (24 of 70) in peripheral blood mononuclear cells (PBMCs) of patients with various types of lung cancers and was 53.6% (15 of 28) in PBMCs of lung adenocarcinoma patients. In combination with the detection of two known marker genes SCC and LUNX, the detection rate was increased to 81.4%. A follow-up study was performed in 37 patients after surgical removal of tumor mass. Among nine patients with persistent detection of two to three tumor marker transcripts in PBMCs, six patients had recurrence/metastasis. In contrast, 28 patients with transient detection of one tumor marker or without detection of any tumor marker were all in remission. Thus, BJ-TSA-9 may serve as a marker for lung cancer diagnosis and as a marker, in combination with two other tumor markers, for the prediction of the recurrence and prognosis of lung cancer patients
Bj: Physical Parts Bj
No full textComments are invited and should be directed to the author at the address listed below. Please do not reproduce in any way without the permission of the authors. A complet
Estimation of the number of periodic orbits
No full textThe main theme of this paper is to estimate, for self-maps f : X --> X of compact polyhedra, the asymptotic Nielsen number N-infinity(f) which is defined to be the growth rate of the sequence {N(f(n))} of the Nielsen numbers of the iterates of f. The asymptotic Nielsen number provides a homotopy invariant lower bound to the topological entropy h(f). To introduce our main tool, the Lefschetz zeta function, we develop the Nielsen theory of periodic orbits. Compared to the existing Nielsen theory of periodic points, it features the mapping torus approach, thus brings deeper geometric insight and simpler algebraic formulation. The important cases of homeomorphisms of surfaces and punctured surfaces are analysed. Examples show that the computation involved is straightforward and feasible. Applications to dynamics, including improvements of several results in the recent literature, demonstrate the usefulness of the asymptotic Nielsen number.MathematicsSCI(E)19ARTICLE1151-18517
Desain Interior Hotel BJ. Perdana Berkonsep Modern dengan Sentuhan Budaya Pasuruan
No full textHotel merupakan salah satu bentuk akomodasi yang dikelola secara komersial, yang disediakan bagi setiap orang untuk memperoleh pelayanan, penginapan berikut makanan dan minuman. Provinsi Jawa Timur, sebagai salah satu wilayah tujuan wisata di Indonesia, menawarkan berbagai macam obyek wisata baik obyek wisata alam, budaya, maupun buatan. Salah satu daerah tujuan wisata di Jawa Timur yang menawarkan keindahan alam yaitu pemandangan alam pegunungan yang salah satunya ada di Kota Pasuruan. Oleh karena itu, diperlukannya sarana akomodasi yang baik secara kualitas dan kuantitas. BJ. Perdana merupakan salah satu hotel terbaik di Kota Pasuruan, letak dari hotel tersebut cukup strategis dan banyak diminati oleh pengunjung. Namun sayang interior hotel tersebut belum tertatat cukup baik, dan tidak menyimbolkan bahwa hotel tersebut berada di kota Pasuruan.
Pada tugas akhir ini penulis meredsain hotel BJ. Perdana berkonsep modern dengan sentuhan budaya Pasuruan. Penulis juga memberikan informasi mengenai budaya yang ada di kota Pasuruan dengan cara di tuangkan dalam desain interiornya. Dengan menerapkan beberapa bentukan hasil budaya serta warna yang menjadi ciri khas kota Pasuruan. Ini bertujuan agar pengunjung tau akan budaya dan ciri khas dari Kota Pasuruan itu sendiri. Dan juga dapat menjadikan media promosi serta ikut andil dalam program pemerintahan Kota Pasuruan.
Dalam mendesain interior restoran diperlukan metode desain. Metode yang digunakan yaitu pengumpulan data, analisa data, konsep dan pengembangan desain, serta desain akhir. Hasil yang diharapkan adalah sebuah desain interior hotel yang menunjang kebudayaan setempat agar dapat melestarikan budaya setempat serta menjadi media promosi kepada para wisatawan yang berkunjung.
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The hotel is a form of commercially managed accommodation, provided for everyone to get service, with food and drinks. East Java Province, as one of the tourist destinations in Indonesia, offers a variety of attractions both natural attractions, culture, and artificial. One of the tourist destinations in East Java that offers natural beauty that is the natural scenery of the mountains one of which is in Pasuruan. Therefore, the need for good accommodation facilities in quality and quantity. BJ. Perdana is one of the best hotels in Pasuruan City, the location of the hotel is quite strategic and much in demand by visitors. But unfortunately the interior of the hotel has not been recorded well enough, and does not symbolize that the hotel is located in the city of Pasuruan. In this final project the author redesigned the hotel BJ. Perdana modern concept with a touch of Pasuruan culture. The author also provides information about the existing culture in the city of Pasuruan by way of pour in interior design. By applying some formation of cultural and color results that characterize the city of Pasuruan. It aims to let visitors know the culture and characteristics of Pasuruan City itself. And also can make the media campaign and take part in government program of Pasuruan City. In designing the interior design method is required. The method used is data collection, data analysis, concept and design development, and final design. The expected result is a hotel interior design that supports the local culture in order to preserve the local culture and become a media campaign to the tourists who visit
Smeringopus roeweri Kraus 1957
No full text<i>Smeringopus roeweri</i> Kraus, 1957 <p>Figs. 745–746, 749–750, 757–758, 765–773, 791–800</p> <p> <i>Smeringopus roeweri</i> Kraus 1957: 226–228, pl. 21, figs. 23–27.</p> <p>Type. Male holotype from Rwanda, no further data, in SMF (RII 7770), examined.</p> <p> Diagnosis. Distinguished from similar species with proximal and distal cheliceral apophyses (<i>S. carli, S. sambesicus, S. lubondai</i>) by shapes of procursus (distal blade-shaped apophyses, Figs. 765–767), bulb (processes of embolus, Figs. 768–770), and cheliceral apophyses (Figs. 771, 772); from <i>S. carli</i> and <i>S. sambesicus</i> also by shorter frontal epigynal plate (Fig. 757).</p> <p>Male (Bendera). Total body length 6.9, carapace width 2.1. Leg 1: 51.3 (14.3 + 0.9 + 13.7 + 19.7 + 2.7), tibia 2: 9.9, tibia 3: 7.5, tibia 4: 10.1; tibia 1 L/d: 52. Habitus as in Figs. 745 and 746. Carapace ochre-yellow with brown median and lateral marks, clypeus with pair of brown stripes, sternum brown with light marks near coxae 2–4 and more medially, legs light brown, tips of femora and tibiae lighter, darker rings on femora and tibiae distally and in patella area, abdomen ochre-gray with distinct dorsal and ventral pattern. Distance PME-PME 205 µm, diameter PME 175 µm, distance PME-ALE 60 µm, distance AME-AME 45 µm, diameter AME 170 µm. Ocular area slightly elevated, secondary eyes with small ‘pseudo-lenses’ (Fig. 796); deep thoracic pit. Chelicerae as in Figs. 771 and 772, with prominent proximal apophyses and small distal apophyses. Palps as in Figs. 749 and 750, coxa with distinct retrolateral apophysis and shallow wide furrow, trochanter barely modified, femur with retrolateral furrow with ventrally distinct rim, procursus with distinctive distal blade-shaped processes (Figs. 765–767, 792, 793), bulb with distinctive complex embolus (Figs. 768–770, 794). Legs without spines, few vertical hairs, with curved hairs on tibiae and metatarsi 1 and 2, retrolateral trichobothrium on tibia 1 at 2%; prolateral trichobothrium present on tibia 1. Gonopore with two epiandrous spigots (Fig. 795).</p> <p>Variation. Tibia 1 in 41 males: 9.6–15.2 (mean 12.2). The holotype is in fair condition but chelicerae and right palp are missing; tibia 1 missing, tibia 2: 9.3; color pattern indistinct (light areas artificially darkened).</p> <p> Female. In general similar to male; tibia 1 in 80 females: 8.4–13.2 (mean 9.8). Epigynum a simple plate, round pockets posteriorly deeper but also anteriorly with distinct rim (Figs. 757, 798); internal genitalia as in Figs. 758 and 773. ALS with eight spigots each (Fig. 799); PMS with two spigots each (Fig. 800). Females from Tatanda (Tanzania) remind of <i>S. peregrinus</i> (anterior rim indistinct, pockets closer together) and are assigned tentatively.</p> <p>Distribution. Known from Rwanda, southeastern Congo D.R. (Tanganyika), western Tanzania, and Malawi (Fig. 718).</p> <p>Material examined. RWANDA: 1♂ type above.</p> <p> CONGO D.R.: <i>Tanganyika Prov.</i>: Terr. d’Albertville, Bendera [5°03’S, 28°54’E], 950 m a.s.l., in <i>Macrotermes</i> nest, x.1958 (N. Leleup), 2♂ 2♀ in MRAC (112886). Kapona [7°11.0’S, 29°08.7’E], iii.1966 (J. Bafort), 1♂ 2♀ 2 juvs. in MRAC (129785 part). Albertville [=Kalemie, 5°56’S, 29°11’E], 1959 (J. Verhoustraete), 1♂ 2♀ in MRAC (115067 part). Mpala, bord lac Tanganika [~ 6°44’S, 29°30’E], 11.vii.1953 (H. Bomans), 45♂ 79♀ in MRAC (75869–918).</p> <p> TANZANIA: <i>Rukwa Region</i>: Sumbawanga Distr., Tatanda, 80 km S of Sumbawanga (8°29.6’S, 31°30.2’E), 1800 m a.s.l., around houses, 3.–4.ii.1997 (P.P. Bjørn, L. Sørensen), 2♂ 4♀ 1 juv. (females assigned tentatively; see above) in ZMUC.</p> <p> MALAWI: <i>Northern Region</i>: Mzimba Distr., 10 mi N Mzimba [~ 11°45’S, 33°35’E], 1610 m a.s.l., 23.ii.1958 (E.S. Ross, R. E. Leech), 1♂ 1♀ in CAS. 41 mi N Mzimba [~ 11°30’S, 33°30’E], 1360 m a.s.l., 23.ii.1958 (E.S. Ross, R. E. Leech), 1♀ in CAS. <i>Southern Region</i>: Mpepwe near Monkey Bay [~ 14°05’S, 34°55’E], 24.ii.1976 (R. Jocqué), 1 ♀ in MRAC (148103).</p>Published as part of <i>HUBER, BERNHARD A., 2012, Revision and cladistic analysis of the Afrotropical endemic genus Smeringopus Simon, 1890 (Araneae: Pholcidae), pp. 1-138 in Zootaxa 3461 (1)</i> on pages 122-124, DOI: 10.11646/zootaxa.3461.1.1, <a href="http://zenodo.org/record/6415657">http://zenodo.org/record/6415657</a>
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