1,720,988 research outputs found
Cisplatin-induced bradycardia: Cardiac toxicity or cardiac hypersensitivity and Kounis syndrome?
No full textCisplatin-induced bradycardia: Cardiac toxicity or cardiac hypersensitivity and Kounis syndrome
Letter by Cervellin et al Regarding Article, "Allergic Inflammation Is Associated With Coronary Instability and a Worse Clinical Outcome After Acute Myocardial Infarction"
No full textWe read with interest the article of Niccoli et al,who demonstrated a significant in vivo eosinophil degranulation and basophils activation during acute coronary syndrome along with a prognostic role of eosinophil cationic protein in ST-segment–elevation myocardial infarction. Indeed, the interplay between ischemic heart disease and atopy/allergy is complex and not completely revealed to date because the first report of acute coronary syndrome during a prolonged allergic reaction to penicillin was published more than half a century ago,followed by several studies supporting a role for allergic mediators in ischemic heart disease. In 1998, Eugene Braunwald described that vasospastic angina may be triggered by allergic reactions with mediators, such as histamine or leukotrienes, acting on coronary vascular smooth muscle. The results of Niccoli et al are consistent with both activation of eosinophil and basophil (both cells involved in allergic reactions) after an acute coronary event, with the additional finding of the prognostic role of elevated eosinophil cationic protein in patients with ST-segment–elevation myocardial infarction. Despite these important evidences, a causality dilemma remains. In fact, it is still unclear as to whether allergic pathway activation anticipates plaque disruption and subsequent acute thrombus formation during myocardial ischemia or, conversely, it just follows the ischemic/necrotic process. The answer to this intriguing issue would permit to recognize whether allergic reactions may be considered simple bystanders or active players in the challenging pathophysiology of myocardial ischemia
Kounis syndrome triggered by a spider bite. A case report
No full textKounis syndrome triggered by a spider bite. A case repor
Cephalosporin triggered Kounis syndrome: Pathophysiological and clinical insights
No full textBackground
Acute coronary syndrome triggered by hypersensitivity to various natural, chemical, or pharmaceutical allergens is known as Kounis syndrome. Kounis syndrome is classified in three subtypes based on its pathophysiological mechanism and outcome. Among pharmaceuticals, cephalosporins are frequently implicated in allergic illnesses, with ceftriaxone being one of the most frequently reported causes. Based on literature reports and our own experience, we reported on the main clinical features regarding ceftriaxone triggered KS (CTKS).
Methods.
Medical records from all CTKS cases, as published by the end of December 2024, were retrieved and analyzed, including a patient admitted to our hospital after inadvertent twice ceftriaxone administration.
Results
Clinical findings from 10 CTKS patients, mean aged 61 ± 18 (range 24–85) years, 5 males, were studied. Type-I KS (coronary vasospasm) was found in 8 cases (80 %), whereas 2 more patients showed a type-II variant (atheromatous plaque thrombosis), with the right artery as the most involved coronary vessel. Apart from transient hemodynamic instability in 2 patients, everyone was discharged in a good clinical condition.
Conclusions
CTKS is a rare, but likely underrecognized, clinical condition that may occur regardless of gender, age, history of allergy or preexisting coronary artery disease. The predominant type-I variant of KS indicates a transient coronary asospasm (and/or microcirculatory impairment) as the most likely pathogenic mechanism. Key pathophysiological, clinical, and prognostic aspects were discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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