20 research outputs found
Portraits of Mina Loy, Marsden Hartley, and Gertrude Stein, from New York Tribune, November 4, 1923
No full textCaricature portraits of Mina Loy, Marsden Hartley, and Gertrude Stein, by Djuna Barnes, from "Book News and Reviews," New York Tribune, circa November 4, 1923. Caption reads: "Three American literary expatriates in Paris-- Mina Loy, the poet author of 'Luna Benamur'; Marsden Hartley, author of 'Ventures in the Arts' and 'Baltasar Fernande'; and Gertrude Stein, spiritual mother of all the modernists, author of 'Tender Buttons,' 'Geography and Plays,' etc. Caricatures by Djuna Barnes, done in Paris.
La significación del inframundo olmeca en el Altar 4 de la Venta, Tabasco. Dimensión Antropológica Vol. 14 Año 5 (1998) septiembre-diciembre
No full textBáez-Jorge, F., "La cosmovisión de los zoques de Chiapas (Reflexiones sobre su pasado y su presente)", en Antropología e historia de los mixe-zoques y mayas. Homenaje de Franz Blom, UNAM, 1983.Barthes, R., "Retórica de la imagen", en La Semiología, Argentina, Editorial Tiempo Contemporáneo, 1976.Blom, F. y 0. Lafarge, Tribes and Temples, vol. 1, The Tulane University of Louisiana, 1926.Castro-Leal, M. y L. Ochoa, Guía arqueológica del parque-museo de La Venta, Tabasco, Gobierno del Estado de Tabasco, 1985.Coquet, M., "Le discours plastique d’un objet ethriographique", en Actes Semiotiques-Documents, vol. 44,1983.Flores, R., "Segmentación y clausura del discurso", en Morphe, Ciencias del Lenguaje, núm. 5, Universidad Autónoma de Puebla, 1991.Foster, G., Sierra Popoluca Folklore and Beliefs, University of California Publications in American Archaeology and Ethriology, vol. 42, núm. 2, 1945.García de León, A., Pajapan: un dialecto mexicano del Golfo, INAH (Científica, 43),1976.____________, "El universo de lo sobrenatural entre los nahuas de Pajapan, Veracruz", en Estudios de Cultura Nahuatl 8, UNAM, 1969.Greimas, A. J., "Semiótica figurativa y semiótica visual", en Figuras y estrategias, México, Siglo XXI, 1994.Ichon, Alain, La religión de los totonacas de la sierra, México, INI, 1973.Keane, T., "Figurativité et perception", en Noveaux Actes Semiotiques 17, Universite de Limoges, France, 1991.Münch, G., "Cosmovisión y medicina tradicional entre los popolucas y nahuas del sur de Veracruz", en Antropología e historia de los mixe-zoques y mayas. Homenaje de Franz Blom, UNAM, 1983.____________, Etnología del istmo veracruzano, Instituto de Investigaciones Antropológicas (Antropología, 50), UNAM, 1983.Reséndiz, R., "Las imágenes del mundo: una visión semiótica", en Pervivencia del signo, UNAM/UAM-Iztapalapa/El Colegio de México, año 1, núm. 1, mayo 1993.Sahagún, Fray Bernardino de, Historia general de las cosas de la Nueva España, México, Editorial P. Robredo, 1938.Saint-Martin, Fernande, Semiotics of Visual Language, Indiana University Press, 1987.En este trabajo se trata de buscar nuevos ámbitos de reflexión sobre el mundo prehispánico y sus significaciones. Para ello tomamos como base metodológica la semiótica de la Escuela de París que, sobre la figuratividad y la semiótica plástica, ha venido realizando trabajos desde los años setenta
Office characteristics and dry eye complaints in European workers–The OFFICAIR study
No full textAbstractObjectivesOcular discomfort is a prevalent health complaint in offices. It is hypothesized that, in addition to individual and occupational factors, the buildings' indoor environment may affect eye complaints. However, insight in potential building-related causal factors, needed to allow development of effective prevention strategies in building design, operation and maintenance is limited. This study aimed to investigate the relations between modern office building characteristics and dry eye complaints.MethodsComprehensive characteristics of 167 office buildings in eight European countries, were linked to questionnaire data from 7441 office workers. Multilevel modeling was applied to explore relations between building characteristics and self-reported dry eye complaints, in a cross-sectional study.ResultsAmong office workers investigated, 34% declared dry eye complaints during the past four weeks. Majority of workers (91.2%) experiencing these symptoms, reported improvement on days away from the office. After full adjustment, the regression model revealed a significant increased risk for: proximity (<100 m) to potential sources of outdoor air pollution (OR: 1.41, 95% CI: 1.06–1.88), absence of operable windows (OR: 1.70, 95% CI: 1.34–2.16), portable humidifiers in the offices (OR: 1.58, 95% CI: 1.18–2.11), exposed concrete and/or plaster (OR: 1.29, 95% CI 1.02–1.62) and dispersion and/or emulsion paint as wall covering in offices (OR: 1.20, 95% CI: 1.01–1.41). A negative association was found for cleaning surfaces at least once per week (OR: 0.75, 95% CI: 0.61–0.91).ConclusionsBuilding characteristics were associated with dry eye complaints of office workers. Focused studies are recommended to investigate underlying causes to prevent these symptoms
Stereoselective Metal-Free Reduction of Chiral Imines in Batch and Flow Mode: A Convenient Strategy for the Synthesis of Chiral Active Pharmaceutical Ingredients
Get PDFhe convenient, metal-free reduction of imines that
contain an inexpensive and removable chiral auxiliary allowed
for the synthesis of the immediate precursors of chiral active
pharmaceutical ingredients (APIs). This protocol was carried out
under batch and flow conditions to give the correspoding prod-
ucts in high yields with almost complete stereocontrol. In the
presence of trichlorosilane, an inexpensive and nontoxic reduc-
ing agent, and an achiral Lewis base such as N,N-dimethyl-
Introduction
The pharmaceutical industry is gradually progressing towards
enantiopure formulations. Most newly introduced drugs are
chiral, and it is expected that approximately 95 % of pharma-
ceutical drugs will be chiral by 2020.
[1]
In this context, chiral
amines are considered a class of paramount importance, be-
cause they are found in a plethora of compounds such as those
of pharmaceutical interest as well as those developed for agro-
chemicals, fragrances, and fine chemicals.
[2]
The reduction of
the C=N group is one of the most widely used approaches to
synthesize chiral amines, and over the last ten years, successful
catalytic enantioselective methods based on both metal-pro-
moted
[3]
and organocatalyzed
[4]
strategies have been devel-
oped.
When an industrial synthesis of a chiral pharmaceutical prod-
uct must be planned, however, issues such as the chemical effi-
ciency and robustness of the procedure, its general applicabil-
ity, and economic considerations become crucially important.
For these reasons, the applications of many chiral catalytic sys-
tems are often not feasible, and the use of inexpensive and
readily available chiral auxiliaries becomes an attractive and
economic alternative. This also holds true for the synthesis of
[a] Dipartimento di Chimica, Università degli Studi di Milano,
via Golgi 19, 20133 Milano, Italy
E-mail: [email protected]
http://users2.unimi.it/Benagliagroup
[b] Istituto di Scienze e Tecnologie Molecolari ISTM-CNR,
Via Golgi 19, 20133 Milano, Italy
[c] Department of Chemistry and Chemistry Center of Évora,
University of Évora,
Rua Romão Ramalho, 59, 7000 Évora, Portugal
Supporting information and ORCID(s) from the author(s) for this article are
available on the WWW under http://dx.doi.org/10.1002/ejoc.201601268.
Eur. J. Org. Chem. 2017, 39–44
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim39
formamide, the formal syntheses of Rivastgmine, calcimimetic
NPS R-568, and a Rho kinases inhibitor were successfully accom-
plished. For the first time, both the diastereoselective imine re-
duction and the auxiliary removal were efficiently performed in
a micro- or mesoreactor under continuous-flow conditions,
which paved the way towards the development of a practical
process for the syntheses of industrially relevant, biologically
active, enantiopure N-alkylamine
Un "Miracle" per a Pere Nunyes
No full textThe main subject of this study is attribution to Pere Nunyes of the sixteenth-century paintings from the current altarpiece of the Holy Sacrament Chapel from the Miracle of Riner Sanctuary (Catalonia). Through the analysis of this paintings, the author enriches the knowledge of the artistic culture of the artist, and, specially, he examines the difficult question about the particular scope of the role that Pere Nunyes played in the contracted works shared with his fellow countryman Henrique Fernandes during his long period of artistic associationEstudi sobre el pintor portuguès Pere Nunyes que es construeix des de l'atribució de les pintures cinccentistes de l'actual retaule de la capella del Santíssim del Santuari del Miracle de Riner (Solsonès). L'anàlisi d'aquestes taules s'aprofita per enriquir el coneixement de la cultura gràfica manipulada per l'artista, i, sobretot, per revisar la complicada qüestió relativa a l'abast concret de la participació de Pere Nunyes en els treballs contractats durant la llarga etapa de la seva associació pictòrica amb el també portuguès Henrique Fernande
Perceived indoor environment and occupants’ comfort in European “Modern” office buildings: The OFFICAIR Study
Get PDFIndoor environmental conditions (thermal, noise, light, and indoor air quality) may affect workers’ comfort, and consequently their health and well-being, as well as their productivity. This study aimed to assess the relations between perceived indoor environment and occupants’ comfort, and to examine the modifying effects of both personal and building characteristics. Within the framework of the European project OFFICAIR, a questionnaire survey was administered to 7441 workers in 167 “modern” office buildings in eight European countries (Finland, France, Greece, Hungary, Italy, The Netherlands, Portugal, and Spain). Occupants assessed indoor environmental quality (IEQ) using both crude IEQ items (satisfaction with thermal comfort, noise, light, and indoor air quality), and detailed items related to indoor environmental parameters (e.g., too hot/cold temperature, humid/dry air, noise inside/outside, natural/artificial light, odor) of their office environment. Ordinal logistic regression analyses were performed to assess the relations between perceived IEQ and occupants’ comfort. The highest association with occupants’ overall comfort was found for “noise”, followed by “air quality”, “light” and “thermal” satisfaction. Analysis of detailed parameters revealed that “noise inside the buildings” was highly associated with occupants’ overall comfort. “Layout of the offices” was the next parameter highly associated with overall comfort. The relations between IEQ and comfort differed by personal characteristics (gender, age, and the Effort Reward Imbalance index), and building characteristics (office type and building’s location). Workplace design should take into account both occupant and the building characteristics in order to provide healthier and more comfortable conditions to their occupants. © 2016 by the authors; licensee MDPI, Basel, Switzerland
Implantação do projeto CRQ verde: a A3P promovendo responsabilidade socioambiental no Conselho Regional de Química da 1a Região (PE - Brasil)
Get PDFAs well as other activities, public agencies are also major consumers of natural resources in
their routine activities, being major consumers of paper, cartridges, light bulbs and electronic
waste. As a way of minimizing the impacts resulting from this consumption, it is often
necessary to implement environmental programs, such as the Public Administration
Environmental Agenda (A3P), initiative of the Ministry of Environment, which allows the
integration of public agencies with a purpose of many of their usage patterns in six thematic
axes. In this sense, aiming at a new administrative organizational culture the Conselho
Regional de Química (CRQ-1), a special federal autarchy, with administrative and patrimonial
autonomy, whose function is to supervise the work of professionals and companies in the field
of Chemistry, which operates throughout the territory of Pernambuco and the territory of
Fernando de Noronha and author, also a workplace, adhered to the aforementioned agenda
with the objective of implementing and disseminating socio-environmental practices using an
A3P as a tool. For the development of this research, the action-research method was used,
since the author is a participant in the process. A3P was used as a guidance tool. A socio-
environmental diagnosis was carried out by completing a checklist, subsequently, the
development of the green CRQ manual was carried out using digital media and and bringing
connections of the suggested action plans with the pillars of A3P and with 2030 Agenda.
From this, it was possible to identify the existing environmental actions both adopted by the
management of the CRQ and by the Charles Darwin Entrepreneur, building where it is based
and which already adopts several sustainable practices. In addition, initiate the
implementation of new actions, such as: sending invoices by email, inserting sustainable
criteria in product purchases, distributing sustainable items at events, among other actions. It
was also possible to plan new environmental actions, which are described and detailed in the
Sustainable Logistics Plan, technical product of this work that will serve as environmental
benchmarking for other organizations. It was possible to verify, through a comparative study,
that approximately 87% of the performance indicators suggested by A3P has a direct
connection with the goals set out in SDG 12, thus highlighting the importance that although
the A3P is voluntary for public agencies, its implementation works as an important tool in
directing the insertion of socio-environmental actions and contributing to the achievement of
the SDGs provided for in the 2030 Agenda. As products of this research, highlights that the
CRQ-1 was the first Conselho Regional de Química and the second in a total of 535
Conselhos Regionais to join the A3P, starting December 8, 2021, the beginning of the
insertion of sustainable practices in the routine activities of the CRQ-1 in a conscious way by
the management and by the servers and also the elaboration of the green CRQ manual.Assim como outras atividades, os órgãos públicos também são grandes consumidores dos
recursos naturais em suas atividades rotineiras, principalmente de papel, cartuchos, lâmpadas
e lixo eletrônico. Como forma de minimizar os impactos decorrentes desse consumo muitas
vezes se faz necessária a implantação de programas ambientais, como é o caso da Agenda
Ambiental da Administração Pública (A3P), iniciativa do Ministério de Meio Ambiente, que
permite a adesão voluntária dos órgãos públicos com a finalidade de rever seus padrões de
consumo, estruturada em seis eixos temáticos. Neste sentido, visando uma nova cultura
organizacional voltada para a sustentabilidade do meio ambiente, o Conselho Regional de
Química da 1a Região (CRQ-1), autarquia federal especial, com autonomia administrativa e
patrimonial, cuja função é fiscalizar o trabalho de profissionais e empresas do ramo da
Química, que atua em todo o Estado de Pernambuco e território de Fernando de Noronha,
aderiu à referida agenda com o objetivo de implantar e disseminar práticas socioambientais
utilizando a A3P como ferramenta. Para o desenvolvimento dessa pesquisa utilizou-se o
método da pesquisa-ação, visto que se trata do local de trabalho da autora e a mesma é
participante do processo. Primeiramente foi realizado um diagnóstico socioambiental por
meio do preenchimento de um checklist e, posteriormente, foi realizada a elaboração do Plano
de Logística Sustentável (PLS) utilizando meios digitais e trazendo conexões dos planos de
ações sugeridos com os pilares da A3P e com a Agenda 2030 da ONU, publicada em 2015,
composta por 17 Objetivos de Desenvolvimento Sustentável (17 ODS). A partir disto, foi
possível identificar as ações ambientais já existentes, tanto adotadas pela gestão do CRQ
quanto pelo Empresarial Charles Darwin, edificação onde o mesmo é sediado e que já adota
diversas práticas sustentáveis. Além disso, foi dado início a implantação de novas ações, tais
como: envio de boletos por email, inserção de critérios sustentáveis nas aquisições de
produtos, distribuição de itens sustentáveis em eventos, entre outras ações. Também foi
possível realizar o planejamento de novas ações ambientais, que seguem descritas e
detalhadas no Manual CRQ Verde, produto técnico deste trabalho que servirá de
benchmarking ambiental para outras organizações. Foi possível verificar, por meio de um
estudo comparativo, que aproximadamente 87% dos indicadores de desempenho sugeridos
pela A3P possui ligação direta com as metas previstas no ODS 12 da Agenda 2030,
destacando assim a importância de que embora a A3P seja de adesão voluntária para os órgãos
públicos, a sua implantação funciona como uma importante ferramenta no direcionamento da
inserção de ações socioambientais e contribuição para o alcance dos ODS previstos na
Agenda 2030. Ainda como resultados dessa pesquisa, destaca-se que o CRQ-1 foi o primeiro
Conselho Regional de Química e o segundo em um total de 535 Conselhos Regionais a
realizar a adesão à A3P, dando início em 08 de dezembro de 2021, na inserção de práticas
sustentáveis nas atividades rotineiras do CRQ-1 de forma consciente pela gestão e pelos
servidores, e também na elaboração do Manual CRQ Verde
Marguerite Yourcenar: a quest for ataraxia; a locus amœnus hindered by absence and presence
No full textThe birth in 1903 of Marguerite Yourcenar, the acclaimed French writer who was the first immortelle to be admitted to the centuries-old male bastion of the Académie française, was followed ten days later by the death of her mother, Fernande. Accordingly, she received an unconventional education almost uniquely at the hands of her father, Michel, whose erudition and passion for history underpinned his persona and heavily influenced the literary corpus of his daughter. Yourcenar’s oeuvre was initiated in her teens with two collections of poetry, the foundations of which lay in myth — a reflection of her father’s influence. Following subsequent collaboration with her father, the creation of a pseudonym to replace her birth name of Marguerite Cleenewerck de Crayencour allowed her rebirth as Marguerite Yourcenar, in which guise she would create an expansive corpus. Her final text was truncated by her death in 1987, providing testament to her tireless literary vitality and drive. Yourcenar’s novels are replete with an atmosphere of pervading death and darkness, and suffused with the motifs of antithesis: birth and death, absence and presence, past and present. Recent scholarship has concentrated on Yourcenar’s torment concerning the circumstances of her birth which suggest the aura of longing, guilt and loss, and maternal abandonment apparent in her texts. Women are portrayed as often mute and pale reflections of the male protagonist, whilst male homosexual liaisons and incest portray unconventional romantic themes, which distance the author’s writing from societal norms. Maternal absence has been suggested as the major catalyst for the spectres which underlie Yourcenar’s texts, whilst paternal absence and/or presence have been overlooked as a motivating force of her corpus. We contend that this is a significant omission in Yourcenarian scholarship which demands the investigation and analysis to be found in the following thesis. This will provide a valuable insight into paternal absence and presence in Yourcenar’s corpus which has until now remained neglected. An investigation of the life of the author and its influence on her self-reflexive style of penmanship, evidence which insistently underlines her texts but which was vehemently denied by Yourcenar, will reveal her literary struggles for liberation from her memories. A study of memory will follow and reinforce the extent to which it acts as a prominent, yet often subconscious catalyst for literary endeavour, whilst an analysis of Denier du rêve, replete with evidence of the author’s torment and resultant quest for ataraxia,1 will demonstrate unrecognised paternal influence in Yourcenar’s oeuvre, heretofore overshadowed by the maternal spectre, and provide the climax for this thesis manifesting the extent to which absence and presence afford powerful inspiration for the Yourcenarian corpus
Department of Error: Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017 (The Lancet (2020) 395(10239) (1779–1801), (S0140673620301148), (10.1016/S0140-6736(20)30114-8))
No full textReiner RC Jr, Hay SI. Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017. Lancet 2020; 395: 1779–801—In this Article, the author byline has been amended to Local Burden of Disease Diarrhoea Collaborators. This correction has been made to the online version as of June 4, 2020, and the printed version is correct
Cancer risks for MSH6 pathogenic variant carriers
No full textIntroduction: Lynch syndrome (LS) is a hereditary cancer syndrome caused by pathogenic variants (PVs) in DNA mismatch repair genes, including MSH6. Although MSH6-associated LS (MSH6-LS) is known to increase the risk of several cancers, precise risk estimates-particularly for non-colorectal cancers-remain uncertain. This limits personalised clinical guidance for MSH6-LS. This study aims to refine cancer risk estimates for individuals with pathogenic or likely pathogenic MSH6 variants. Methods: A retrospective cohort study was conducted using data from 360 Dutch families, comprising 1117 MSH6 PV carriers identified between 1995 and 2020. Pedigree data were collected from multiple clinical centres. Cancer diagnoses were confirmed through medical records where available. Age- and sex-specific hazard ratios (HRs) and cumulative risks (CRs) were calculated using segregation analysis, adjusted for ascertainment bias. Results: By age 80, the cumulative CRC risk was 36 % for males (95 % CI: 25-48 %) and 21 % for females (95 % CI: 13-32 %). For endometrial cancer, the CR was 23 % in females (95 % CI: 15-43 %). At age 40, CRC risk remained low: 0.2 % in males and 0.9 % in females. Elevated lifetime risks were observed for ovarian cancer (6.4 %; HR 5.58), urinary tract cancers (10.1 % in males, 4.1 % in females; HR 2.52), and biliary tract cancers (4.9 % in males, 4.2 % in females; HR 2.76). No increased risk was found for prostate or breast cancer. Conclusion: These refined, age- and sex-specific risk estimates for MSH6 PV carriers inform tailored surveillance strategies, supporting delayed CRC screening and individualised counselling on risk-reducing surgery for women
