305,925 research outputs found
Correction to: The ‘can do, do do’ concept in COPD; quadrant interpretation, affiliation and tracking longitudinal changes
No full textFollowing publication of the original article [1], the authors identified a mistake in the author names, as both forename and initials were stated. Initially published author names: A. J. Alex van ’t Hul, E. H. Noortje Koolen, H. W. Jeroen van Hees, B. Bram van den Borst and M. A. Martijn Spruit Correct author names: Alex J. van ‘t Hul, Noortje H. Koolen, Jeroen W. van Hees, Bram van den Borst, Martijn A. Spruit. The original article has been corrected.</p
Koolen-de Vries Syndrome: a journey from diagnosis to treatments
No full textThe Koolen-de Vries Syndrome Foundation was founded in 2013 with the mission to educate, increase awareness, promote research and develop treatments for individuals living with Koolen-de Vries Syndrome (KdVS) and their families. With this aim, the foundation has focused on: developing scientific resources through patient cell and animal models, providing seed funding to basic and clinical researchers, establishing a natural history study of KdVS and increasing patient engagement. Projects have been prioritized across these areas of focus with an emphasis on expanding international research on KdVS, supporting translational research, establishing an international natural history study and conducting studies to assess patient priorities. With the incredible growth amongst our research and patient community in the last decade, our goal is to have our first clinical trial for KdVS in 2026
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Análise comparativa de famílias gênicas NRPS-PKS em Trichoderma: mecanismos evolutivos e diversificação biossintética de peptaibols.
No full textA mineração genômica é uma ferramenta essencial para investigar a diversidade de produtos naturais em fungos filamentosos. Avanços recentes em genômica têm impulsionado a descoberta de peptídeo sintetases não ribossomais (NRPSs); entretanto, a complexidade dos clusters de genes biossintéticos (BGCs) nesses organismos demanda abordagens computacionais integradas para análise sistemática. Neste trabalho, foi aplicado um pipeline que combina FungiSMASH para a predição e anotação de BGCs, além das plataformas BiG-SCAPE e CORASON, que permitem a construção de redes de similaridade, identificação de famílias gênicas e análise filogenética baseada em assinaturas enzimáticas. Investigamos 150 genomas de diferentes espécies de Trichoderma, destes, 60 genomas foram obtidos no NCBI, 80 no JGI e 10 oriundos do sequenciamento de linhagens da coleção da Embrapa Amazônia Ocidental, incluindo a linhagem CPAA-TM15, nova espécie Trichoderma isolada do rio Purus (Amazonas) filogeneticamente relacionada a Trichoderma subazureum e Trichoderma spirale.ID do trabalho: 204/1213-0
Atividade antimicrobiana de bactérias isoladas do rio negro e Rio Solimões contra fitopatógenos de importância agrícola.
No full textA Bacia Amazônica drena mais de sete milhões de metros quadrados de terras e tem uma vazão anual média de 180.000 m³/segundo (1). Os rios da Amazônia apresentam diferenças marcantes na coloração e na transparência da água devido, principalmente, às características físico-químicas (pH, condutividade, dureza, oxigênio dissolvido e matéria orgânica dissolvida), biológicas e geológicas, influenciando diretamente a composição e a formação dos diferentes tipos de água (preta, clara e branca) (2). A diversidade da microbiota aquática dos sedimentos dos rios amazônicos, devido aos poucos estudos, pode representar uma fonte inexplorada para a obtenção de bioativos aplicados em cadeias produtivas diversas, como: agroindústria, farmacêutica e alimentícia. Neste contexto, o presente estudo tem como objetivo selecionar bactérias dos rios Negro e Solimões produtoras de antimicrobianos contra os fitopatógenos: Corynespora cassiicola, Colletotrichum siamense, Ralstonia solanacearum e Rhizoctonia solani
The vertex-connectivity of a distance-regular graph
No full textThe vertex-connectivity of a distance-regular graph equals its valency. (C) 2008 Dr Andries E. Brouwer. Published by Elsevier Ltd. All rights reserved.X1118sciescopu
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A new family of distance-regular graphs with unbounded diameter
No full textWe construct distance-regular graphs with the same - classical - parameters as the Grassmann graphs on the e-dimensional subspaces of a (2e + 1)-dimensional space over an arbitrary finite field. This provides the first known family of non-vertex-transitive distance-regular graphs with unbounded diameter.X1127sciescopu
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
Bounds for the Hückel energy of a graph
No full textLet G be a graph on n vertices with r := left perpendicularn/2right perpendicular and let lambda(1) >= center dot center dot center dot >= lambda(n) be adjacency eigenvalues of G. Then the Huckel energy of G, HE(G), is defined as HE(G) = {2 Sigma(r)(i=1)lambda(i), if n = 2r; 2 Sigma(r)(i=1)lambda(i) + lambda(r+1), if n = 2r + 1. The concept of Huckel energy was introduced by Coulson as it gives a good approximation for the pi-electron energy of molecular graphs. We obtain two upper bounds and a lower bound for HE(G). When n is even, it is shown that equality holds in both upper bounds if and only if G is a strongly regular graph with parameters (n, k, lambda, mu) = (4t(2) + 4t + 2, 2t(2) + 3t + 1, t(2) + 2t, t(2) + 2t + 1), for positive integer t. Furthermore, we will give an infinite family of these strongly regular graph whose construction was communicated by Willem Haemers to us. He attributes the construction to J.J. Seidel.X111sciescopu
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