1,720,996 research outputs found
Safety and efficacy of travoprost solution for the treatment of elevated intraocular pressure
Full text linkTravoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension. It exerts its ocular hypotensive effect through the prostaglandin FP receptors, located in the ciliary muscle and the trabecular meshwork. Several studies have shown that topical administration of travoprost induces a mean IOP reduction ranging from 25% to 32%, and sustained throughout the 24-hour cycle. When compared with timolol, travoprost is more effective at reducing IOP, while generally no difference has been found in the head-to-head comparison with other prostaglandin analogues. The fixed combination of travoprost and timolol has demonstrated a hypotensive efficacy comparable to the concomitant administration of the two drugs. Recently, a new preservative-free formulation of travoprost 0.004% has been marketed for reducing tolerability-related problems in subjects affected with ocular surface disease. Low rates of topical and systemic adverse reactions, strong ocular hypotensive efficacy, and once-a-day dosing make travoprost a first-line treatment for patients affected with elevated IOP
Needle revision with 5-fluorouracil for the treatment of ahmed glaucoma valve filtering blebs 5-fluoruracil needling revision can be a useful and safe tool in the management of failing ahmed glaucoma valve filtering blebs
No full textEfficacy and safety of Migs in exfoliative glaucoma
No full textΒιβλιογραφία : σ.32-40Το γλαύκωμα, σύμφωνα με τον Παγκόσμιο Οργανισμό Υγείας αποτελεί την δεύτερη κυριότερη αιτία τύφλωσης στον πλανήτη, επηρεάζοντας 60 εκατομμύρια ανθρώπους παγκοσμίως. Είναι μια πολυπαραγοντική νόσος η οποία εξαρτάται μεταξύ άλλων από την ενδοφθάλμια πίεση και συναντάται κυρίως σε άτομα άνω των 55 ετών. Με την αυξανόμενη μέση ηλικία του παγκόσμιου πληθυσμού πρόκειται να αυξηθεί και η ανάγκη αποτελεσματικής αντιμετώπισης του γλαυκώματος. Η αντιμετώπιση του γλαυκώματος βασίζεται σε φαρμακολογικές και χειρουργικές θεραπείες που έχουν ως στόχο τη μείωση της ενδοφθάλμιας πίεσης. Το αποφολιδωτικό σύνδρομο αποτελεί μια συστημική νόσο, της οποίας τα αποτελέσματα βλέπουμε κυρίως στον οφθαλμό. Η παρουσία αποφολιδωτικού υλικού αυξάνει τον κίνδυνο εμφάνισης γλαυκώματος και οδηγεί σε επιθετικότερες μορφές γλαυκώματος λόγω της μεγαλύτερης διακύμανσης της ενδοφθάλμιας πίεσης κατά της διάρκεια του 24ώρου. Μια επιθετικότερη μορφή γλαυκώματος συνοδεύεται συνήθως από μεγαλύτερη πιθανότητα ανάγκης για χειρουργική επέμβαση σε κάποιο στάδιο προόδου της νόσου. Στην Ελλάδα η αποφολίδωση αποτελεί συχνό αίτιο γλαυκώματος.Οι MIGS αποτελούν μια νέα και εξελισσόμενη μορφή χειρουργικών επεμβάσεων γλαυκώματος, συνδυασμένες ή όχι με την επέμβαση φακοθρυψίας καταρράκτη. Υπόσχονται ρύθμιση της ενδοφθάλμιας πίεσης περίπου στα 15mmHg με ένα πολύ καλό προφίλ ασφαλείας. Αν και έχουν χρησιμοποιηθεί περισσότερο σε ασθενείς με πρωτοπαθές γλαύκωμα ανοιχτής γωνίας τα αποτελέσματα των ασθενών με δευτερογενή γλαυκώματα, ειδικότερο το αποφολιδωτικό γλαύκωμα, είναι ιδιαίτερα ενθαρρυντικά. Μια τέτοιου είδους επέμβαση μπορεί να χρησιμοποιηθεί είτε για την αποτελεσματικότερη αντιμετώπιση της ενδοφθάλμιας υπέρτασης είτε για την μείωση των φαρμάκων που απαιτείται να χρησιμοποιεί καθημερινά ο ασθενής.Glaucoma, according to the World Health Organization, is the second most common cause of blindness in the world, affecting about 60 million people. It is a multifactorial disease which depends, between others, on the intraocular pressure and is more commonly seen in patients of more than 55 years of age. With the ongoing increase in population age, it is expected to have an increase in the incidence of glaucoma, accompanied with an increased need for effectively managing it. Glaucoma managements is based on pharmacological and surgical treatments which have as a main target the decrease of the intraocular pressure. Εxfoliative syndrome is a systemic disorder, of which the results we can mainly see in the eyes of the patient. The presence of exfoliative material leads to an increased risk of glaucoma and also to more aggressive forms of glaucoma due to the tendency of the intraocular pressure to widely vary during 24hrs. A more aggressive type of glaucoma is usually accompanied with a higher probability of need for a surgical intervention during some stage of the disease. In Greece exfoliation is a common cause of glaucoma.MIGS are a new and progressing type of surgical interventions for glaucoma, combined or not with the phacoemulsification of the cataract lens. They promise successful regulation of the intraocular pressure to 15mmHg in an average and they are accompanied with an excellent safety profile. Even though they have been mostly used in patients with a primary open angle glaucoma, the results in patients with secondary types of glaucoma, and specifically exfoliative, are exceptionally encouraging. This type of intervention could be used either to successfully manage intraocular hypertension or in attempt to decrease the need of daily drop installation.40 σ
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Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients
Full text linkTo evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p < 0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients
Elevated intraocular pressure in patients with acromegaly
No full textTo evaluate central corneal thickness (CCT) and intraocular pressure (IOP) in a cohort of acromegalic patients, and to correlate CCT with serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1)
Quality of Life in Glaucoma: A Review of the Literature
Full text linkThe ultimate goal of glaucoma management is
the preservation of patients’ visual function and
quality of life (QoL). The disease itself as well as
the medical or surgical treatment can have an
enormous impact on a patient’s QoL. Even the
mere diagnosis of a chronic, irreversible,
potentially blinding disorder can adversely
affect the patient’s sense of well-being and
QoL by eliciting significant anxiety. Patients
with primary open-angle glaucoma rarely
present with visual symptoms, at least early in
the course of the disease. A better
understanding of patient-reported QoL can
improve patient–physician interaction and
enhance treatment adherence by customizing
treatment options based on individual patient
profile, thus optimizing long-term prognosis.
These aspects are summarized and critically
appraised in this articl
Glaucoma and neuroinflammation: an overview
No full textGlaucoma is an optic neuropathy characterized by well-defined optic disc morphological changes (i.e. cup enlargement, neuroretinal border thinning, and notching, papillary vessel modifications) consequent to retinal ganglion cell loss, axonal degeneration, and lamina cribrosa remodeling. These modifications tend to be progressive and are the main cause of functional damage in glaucoma. Despite the latest findings about the pathophysiology of the disease, the exact trigger mechanisms, and the mechanism of degeneration of retinal ganglion cells and their axons have not been completely elucidated. Neuroinflammation may play a role in both the development and the progression of the disease as a result of its effects on retinal environment and retinal ganglion cells. We summarize the latest findings about neuroinflammation in glaucoma and examine the connection between risk factors, neuroinflammation, and retinal ganglion cell degeneration
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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