53 research outputs found
Εκτίμηση της συνδυαστικής χορήγησης silibinin και sorafenib στην καρκινική κυτταρική σειρά ήπατος HepG2
No full textΒιβλιογραφία : σ. 92-114Σκοπός: Το sorafenib είναι πολυαναστολέας κινασών τυροσίνης που βρίσκεται στην πρώτη γραμμή επιλογής για την αντιμετώπιση του προχωρημένου καρκίνου του ήπατος. Η silibinin ανήκει στις φλαβονολιγνάνες και είναι γνωστή για την δράση της εναντίον διαφόρων τύπων καρκίνου, καθώς και εναντίον παθήσεων του ήπατος και των χοληφόρων. Στην παρούσα μελέτη διερευνήθηκε in vitro η συνδυαστική δράση των δύο παραγόντων έναντι του ηπατοκυτταρικού καρκίνου. Υλικά και μέθοδοι: Στην καρκινική κυτταρική σειρά HepG2 εκτιμήθηκε η βιωσιμότητα των κυττάρων παρουσία του sorafenib ή/και της silibinin, σε διάφορες συγκεντρώσεις, μέσω της δοκιμασίας ΜΤΤ (βρωμιούχου διμεθυλθιαζολ- διφαινυτετραζολίου), καθώς και η μεταναστευτική ικανότητα των κυττάρων με τη δοκιμασία προσομοίωσης επούλωσης τραύματος (would healing assay). Αποτελέσματα: Η συνδυαστική χορήγηση sorafenib και silibinin επηρέασε την κυτταρική βιωσιμότητα με χρονοεξαρτώμενο αλλά όχι, σε γενικές γραμμές, δοσοεξαρτώμενο τρόπο. Η συνδυαστική χορήγηση 5μΜ sorafenib με 75μΜ silibinin είχε αποτελέσματα συγκρίσιμα με αυτά της μεμονωμένης χορήγησης 7,5 ή 10μΜ sorafenib. Παράλληλα, παρατηρήθηκε και αναστολή της μετανάστευσης των κυττάρων υπό την παρουσία των δύο ουσιών. Σχεδόν όλες οι συνδυαστικές χορηγήσεις φάνηκε μάλιστα ότι υπερείχαν των αντίστοιχων μεμονωμένων χορηγήσεων. Συμπεράσματα: Η συγχορήγηση sorafenib και silibinin φαίνεται να έχει ενθαρρυντικά αποτελέσματα. Οι μηχανισμοί δράσης της συνδυαστικής χορήγησης τους όμως θα πρέπει να αποσαφηνιστούν. Περαιτέρω in vitro και in vivo μελέτες κρίνονται απαραίτητες ώστε να εκτιμηθεί εάν ο συγκεκριμένος συνδυασμός θα μπορούσε να χρησιμοποιηθεί στην κλινική πράξη.Background/Aim: Sorafenib is a tyrosine kinase multi-inhibitor which is the first choice in treatment of high grade hepatocellular carcinoma (HCC). Silibinin is a flavonolignan known for its anticancer effect against different types of cancer, as well as liver and biliary diseases. The aim of the current study is to investigate the combined effect of these agents against HCC in vitro. Materials and Methods: Cell viability was assessed on HepG2 HCC cell line, by using the MTT assay, after administering sorafenib or silibinin alone and in combination in a range of concentrations. Cell migration was assessed by applying the wound healing assay.Results: Sorafenib and silibinin combined treatment, reduced cell viability in HepG2 cells mainly in a time- and less in a dose-dependent manner. The combined administration of 5μΜ sorafenib and 75μΜ silibinin was as effective as the administration of 7.5 or 10μΜ of sorafenib alone. Additionally, cell migration was more effectively inhibited by the combined treatment. Conclusion: The combination of sorafenib and silibinin seems to be a promising therapeutic approach. The mechanisms of action need to be elucidated. Further in vitro and in vivo studies are needed in order to clarify whether this combination could be used in clinical practice.114 σ
διαχείριση γονιδιακού και γενετικού υλικού. Συμμετοχή του στρατού σε ερευνητικά προγράμματα για ιατρικούς σκοπούς
No full textΒιβλιογραφία : σ.74-79Στόχος της εργασίας είναι να παρουσιάσει και να σχολιάσει τα ζητήμα-τα βιοηθικής που ανακύπτουν στην πειραματική στρατιωτική ιατρική έρευνα σε παγκόσμιο επίπεδο υπό το πρίσμα μιας μελλοντικής εφαρ-μογής και αξιοποίηση των αποτελεσμάτων τους από τον ελληνικό στρατό. Η εξέλιξη της γονιδιωματικής επιστήμης έχει προκαλέσει το παγκόσμιο ενδιαφέρον για τις δυνατότητες που υπόσχεται στη βελτί-ωση της ιατρικής φροντίδας των μελών του στρατού αλλά και στην υ-ποβοήθηση της στρατολόγησης , της εκπαίδευσης, της ειδίκευσης και της εκτέλεσης των στρατιωτικών αποστολών. Η τεχνολογία του γονι-διώματος άρχισε να κυριαρχεί στο χώρο της βιοηθικής καθώς η ιδιωτι-κότητα, η εμπιστευτικότητα και η ανανέωση της συγκατάθεσης είναι θέματα που ανατέλουν με την ανάπτυξη των τεχνολογιών αυτών. Η ενίσχυση της ανθρώπινης απόδοσης είναι η προσπάθεια άμεσης αλλα-γής όχι της ασθένειας αλλά της φυσιολογικής κατάστασης ενός ατόμου διανοητικά και σωματικά με σκοπό να βελτιωθούν οι εγγενείς δυνατό-τητες και ικανότητες. Για την εφαρμογή των τεχνολογιών ενίσχυσης η ενημερωμένη συγκατάθεση απαιτείται σε συνδυασμό με ιατρική επίβ-λεψη για την ασφάλεια της χρήσης των ενισχυτών. Με την εθελούσια συμμετοχή στο σώμα του στρατού οι στρατιώτες συναινούν στην υπα-κοή σε διαταγές ανωτέρου. Η συνθήκη αυτή δημιουργεί μια ευαλω-τότητα για τους στρατιώτες. Μέσα από αυτή την οπτική η στρατιωτική αναγκαιότητα οδηγεί πολλές φορές ένα στρατιώτη να αποκηρύξει μέρος των ατομικών του δικαιωμάτων εις όφελος του συλλογικού καλού. Για πολλούς σχολιαστές η παραπάνω συνθήκη κατατάσσει το στρατιωτικό πληθυσμό στους ευάλωτους πληθυσμούς σε σχέση με την πειραματική ιατρική έρευνα. Το κανονιστικό και ρυθμιστικό πλαίσιο για την εφαρμογή της πειραματικής ιατρικής έρευνας στο στρατιωτικό προσωπικό οφείλει να διασφαλίζει την αυτονομία και την ελεύθερη επιλογή.The aim of this study is to present and comment on bioethical issues in the experimental military medical research worldwide in light of a futu-re implementation and exploitation of their results by the Greek army. The development of science in genomics has generated global interest in the possibilities that promises to improve the medical care of military members and assist in the recruitment, training, skills and execution of military missions. The genome technology began to dominate the field of bioethics as privacy, confidentiality and the renewal of consent are matters that rises with the development of these technologies. Enha-ncing human performance is the effort of healing not the disease but rather changing the physiological state of a person’s ( mentally and physically) in order to improve the inherent features and capabilities. For the purposes of enhancement technologies informed consent is required in conjunction with medical supervision for the safety of the use of enhancements. When soldiers volunteer to participate in the body of Army acquiesce in obedience to superior orders. This condition creates a vulnerability for soldiers. Military necessity often leads a soldier to renounce part of his individual rights in favor of the collective good. For many commentators, the above condition classifies military population to vulnerable populations in relation to experimental medical research. The legislative and regulatory framework for the implementation of experimental medical research on military personnel should ensure the autonomy and freedom of choice.79 σ
HERMENEUTICS OF THE WARIA: WARIA’S HERMENEUTICAL TAFSIR OF AL-FATIHAH
No full textQur’an, as it is believed by Muslims, is The Holy Book as well as the manifestation of The Words of God (Kalamullah). It has meanings which obviously was being ‘monopolized’ by The Ulama. In regarding of consequence, the authority of interpreting this Kalamullahseems ‘limited’ only for particular groups. Then, according the author it becomes the main factor leads the stagnancy of Quranic interpretation studies in this modern era. In this context, Schleiermacher’s teory about ‘psychological explication’ (1998), Paul Ricoeur’s theory about ‘distantiation and appropriation’ (1976), and ‘the marginalized reading of Scripture’ theory proposed by Simopoulos (2007), create a new path in interpreting Quran. From those theories, the author sheds the lights on hermeneutical interpretation of al-Fatihahby as one of the marginalized groups in Indonesia, the Waria. This paper concludes that the waria use their hermeneutical way of understanding the Scripture and produce not only anoriginal interpretation, but also contextual and full of theological reflections.Qur’an, as it is believed by Muslims, is The Holy Book as well as the manifestation of The Words of God (Kalamullah). It has meanings which obviously was being ‘monopolized’ by The Ulama. In regarding of consequence, the authority of interpreting this Kalamullahseems ‘limited’ only for particular groups. Then, according the author it becomes the main factor leads the stagnancy of Quranic interpretation studies in this modern era. In this context, Schleiermacher’s teory about ‘psychological explication’ (1998), Paul Ricoeur’s theory about ‘distantiation and appropriation’ (1976), and ‘the marginalized reading of Scripture’ theory proposed by Simopoulos (2007), create a new path in interpreting Quran. From those theories, the author sheds the lights on hermeneutical interpretation of al-Fatihahby as one of the marginalized groups in Indonesia, the Waria. This paper concludes that the waria use their hermeneutical way of understanding the Scripture and produce not only anoriginal interpretation, but also contextual and full of theological reflections
Hermeneutics of the Waria: Waria's Hermeneutical Tafsir of Al-fatihah Fazlul Rahman Icrs Universitas Gadjah Mada, YOGYAKARTA
No full textQur‟an, as it is believed by Muslims, is The Holy Book as well as the manifestation of TheWords of God (Kalamullah). It has meanings which obviously was being „monopolized‟by The Ulama. In regarding of consequence, the authority of interpreting thisKalamullahseems „limited‟ only for particular groups. Then, according the author itbecomes the main factor leads the stagnancy of Quranic interpretation studies in thismodern era. In this context, Schleiermacher‟s teory about „psychological explication‟(1998), Paul Ricoeur‟s theory about „distantiation and appropriation‟ (1976), and „themarginalized reading of Scripture‟ theory proposed by Simopoulos (2007), create a newpath in interpreting Quran. From those theories, the author sheds the lights onhermeneutical interpretation of al-Fatihahby as one of the marginalized groups inIndonesia, the Waria. This paper concludes that the waria use their hermeneutical way ofunderstanding the Scripture and produce not only anoriginal interpretation, but alsocontextual and full of theological reflections
Recurrent prurigo nodularis related to infected tonsils: a case report
No full textAbstract Introduction Prurigo nodularis is an unusual disorder of unknown aetiology, which is notoriously resistant to therapy, and is characterized by extremely pruritic nodules with well-defined clinical symptoms and histopathological findings. Case presentation We report the case of a patient presenting with pruritic papules and nodules on his legs, arms and trunk over the past 4 years, recurring after episodes of acute tonsillitis. Although oral and topical corticosteroids, oral antibiotics and emollients were used in his therapy, only tonsillectomy finally proved the definitive treatment. Conclusion We discuss the aetiopathogenesis, diagnosis and treatment of prurigo nodularis associated with chronic tonsillitis, and we further review the literature on this rare condition.</p
Bajji on the Beach: Middle-Class Food Practices in Chennai’s New Beach
No full textThis book produced by a group of interdisciplinary and international researchers working on a wide variety of cities throughout Asia, Latin America and Europe, addresses, rethinks and, in some cases, abandons the notions of formal and ..
Esophageal and small bowel obstruction by occupational bezoar: report of a case
No full textAbstract Background Phytobezoar may be a cause of bowel obstruction in patients with previous gastric surgery. Most bezoars are concretions of poorly digested food, which are usually formed initially in the stomach. Intestinal obstruction (esophageal and small bowel) caused by an occupational bezoar has not been reported. Case presentation A 70-year old male is presented suffering from esophageal and small bowel obstruction, caused by an occupational bezoar. The patient has worked as a carpenter for 35 years. He had undergone a vagotomy and pyloroplasty 10 years earlier. The part of the bezoar, which caused the esophageal obstruction was removed during endoscopy, while the part of the small bowel was treated surgically. The patient recovered well and was discharged on the 8th postoperative day. Conclusions Since occupational bezoars may be a cause of intestinal obstruction (esophageal and/or small bowel), patients who have undergone a previous gastric surgery should avoid occupational exposures similar to the presented case.</p
Ectopic Pancreatic Tissue Adherent to the External Gallbladder Wall
No full textHeterotopic pancreatic tissue can be found in the gastrointestinal tract, with the stomach and small bowel being the most common sites of localization. The gallbladder is seldom affected. Here, we report 2 cases of ectopic pancreas within the fatty tissue adherent to the organ wall. Both cases concerned young women (31 and 36 years old) who were treated with a laparoscopic cholecystectomy due to persistent abdominal symptoms thought to be related to chronic cholecystitis. Pathological examination revealed the presence of ectopic pancreatic tissue type 1. © 2018 The Author(s). Published by S. Karger AG, Basel
The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis
No full textPMCID: PMC3631166This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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