1,721,140 research outputs found
"Rescue" technologies following high-dose chemotherapy for breast cancer: how social context shapes the assessment of innovative, aggressive, and lifesaving medical technologies
No full textIn 1995, two women at Dana-Farber Cancer Institute were given accidental overdoses of chemotherapy as they underwent experimental high-dose treatment for metastatic breast cancer. One woman died, the other was seriously injured. The goal of high-dose chemotherapy is to kill the maximum numberof cancer cells; the drugs used are so potent they destroy not only the malignant cells but the patient's own blood-producing system as well. Even at conventional levels, the drugs given are highly toxic. Experimental high-dose chemotherapy requires doses so large the patient must subsequently be "rescued" by infusion of new bone marrow or blood-producing stem cells. Breast cancer patients risk death in order to buy a chance at cure. The mistaken doses of chemotherapy at Dana-Farber tragically highlight the tension between hope for cure and the destructive potential of aggressive, potentially life-saving therapies. If desperate women—and their physicians—are willing to take such risks, how can new therapies such as bone marrow transplant for breast cancer be evaluated? Innovative, dramatic, and lifesaving technologies hold special cultural appeal in the United States. What features of this unique social context shape the technology assessment process
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Open Petri nets: Non-deterministic Processes and Compositionality
No full textWe introduce ranked open nets, a reactive extension of Petri
nets which generalises a basic open net model introduced in a previous
work by allowing for a refined notion of interface. The interface towards
the external environment of a ranked open net is given by a subset
of places designated as open and used for composition. Additionally, a
bound on the number of connections which are allowed on an open place
can be specified. We show that the non-deterministic process semantics
is compositional with respect to the composition operation over ranked
open nets, a result which did not hold for basic open nets
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A framework for the verification of infinite-state graph transformation systems
No full textWe propose a technique for the analysis of infinite-state graph transformation systems, based on the construction of finite structures approximating their behaviour. Following a classical approach, one can construct a chain of finite under-approximations (k-truncations) of the Winskel style unfolding of a graph grammar. More interestingly, also a chain of finite over-approximations (k-coverings) of the unfolding can be constructed. The fact that k-truncations and k-coverings approximate the unfolding with arbitrary accuracy is formalised by showing that both chains converge (in a categorical sense) to the full unfolding. We discuss how the finite over- and under-approximations can be used to check properties of systems modelled by graph transformation systems, illustrating this with some small examples. We also describe the Augur tool, which provides a partial implementation of the proposed constructions, and has been used for the verification of larger case studies
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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