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Çölyak tanılı çocuklarda serum NGAL ve zonulin düzeylerinin belirlenmesi ve bu belirteçlerin glutensiz diyete uyum ile ilişkisinin incelenmesi
No full textÇölyak hastalığı (ÇH), immün sistemin aracılık ettiği, diyetle gluten proteini alınmasıyla ortaya çıkan kronik bir enteropatidir. Glutensiz diyetin (GD) ömür boyu yapılması klinik ve histopatolojik düzelme sağlar. NGAL, farklı dokulardan fizyolojik miktarlarda salınmakla birlikte özellikle intestinal inflamasyonda enterosit ve nötrofillerden salınımı artan bir akut faz glikoproteinidir. Zonulin, gluten alımı ile tetiklenerek enterositler arasındaki sıkı bağlantıların açılmasından ve böylece bağırsak geçirgenliğinin artmasından sorumlu bir proteindir. Çalışmamızda çölyak hastası çocuklarda serum NGAL ve zonulin düzeylerini tespit ederek bu belirteçlerin glutensiz diyete uyum ve dolaylı olarak histopatolojik evre ile ilişkisini araştırmayı hedefledik. Çalışmaya toplam 70 çölyak hastası çocuk alındı. Hastalar; tarafımızca takipli en az 1 yıldır glutensiz diyet altındaki çölyak hastaları (GDA-ÇH) (n:35) ve yeni tanı alıp glutensiz diyet başlanmamış çölyak hastaları (GDB-ÇH) (n:35) olmak üzere 2 gruba ayrıldı. Kontrol grubu olarak kronik hastalığı olmayan yaş ve cinsiyeti hastalar ile uyumlu sağlıklı çocuklar (n:70) dahil edildi. Glutensiz diyete uyumları diyet skorlaması ve DTG IgA ile belirlendi. NGAL ve zonulin, katılımcıların serumlarından ELISA yöntemi ile analiz edildi. Serum NGAL, ÇH'lerde (130,6±138,9 ng/ml) kontrol grubuna (22,7±28,3 ng/ml) göre anlamlı derecede yüksek saptandı (p0,0001). Benzer şekilde serum zonulin, ÇH'lerde (14±3,2 ng/ml) kontrol grubuna (9,1±4,3 ng/ml) kıyasla anlamlı olarak yüksek bulundu (p0,0001). Glutensiz diyete uyum skoru ve DTG IgA antikor titresi ile serum NGAL ve zonulin seviyelerinin anlamlı ilişkisi saptanmadı (p>0,05). Ayrıca, hasta grubunun histopatolojik evresi ile bu belirteçler arasında da anlamlı fark görülmedi. Çalışmamız literatürde, çölyaklı çocuk hastaların kontrol grubuyla karşılaştırılarak serum NGAL ve serum zonulin düzeyinin incelendiği ilk çalışmadır. Bulgularımız NGAL'in çölyak hastalığında inflamasyonun önemli bir bileşeni olduğunu kanıtlar niteliktedir. Çölyak hastalarında serum NGAL ve zonulinin biyobelirteç olarak kullanılabileceğini düşünmekteyiz. Bu belirteçlerin glutensiz diyete uyum ve patolojik tutulum şiddeti ile ilişkisini değerlendirmek için daha geniş serilerin katıldığı klinik çalışmalara ihtiyaç vardır.Celiac disease (CD) is a chronic enteropathy mediated by the immune system that occurs when dietary gluten protein is removed. Adherence to gluten free diet (GFD) for a lifetime provides clinical and histopathological improvement. NGAL is an acute phase glycoprotein which is released from enterocytes and neutrophils especially in intestinal inflammation, although it is released from different tissues in physiological amounts. Zonulin is a protein that is responsible for the opening of tight connections between enterocytes by triggering gluten uptake, thereby increasing intestinal permeability. In this study, we aimed to investigate serum NGAL and zonulin levels in children with celiac disease and to investigate the relationship of these markers with gluten-free diet and indirectly with histopathological stage. A total of 70 children with celiac disease were included in the study. Patients celiac patients with gluten free diet (GDA-CD) (n: 35) and newly diagnosed celiac patients (GDB-CD) (n: 35) who were newly diagnosed and had not started a gluten-free diet. Healthy children (n: 70) who were compatible with age and sex patients without chronic disease were included as the control group. Compliance with gluten-free diet was determined by diet scoring and DTG IgA. NGAL and zonulin were analyzed by ELISA from the sera of the participants. Serum NGAL was significantly higher in CD (130.6 ± 138.9 ng/ml) than in the control group (22.7±28.3 ng/ml) (p 0.0001). Similarly, serum zonulin was significantly higher in CD (14±3.2 ng/ml) than in the control group (9.1±4.3 ng/ml) (p0.0001). Gluten-free diet compliance score and DTG IgA antibody titer were not significantly associated with serum NGAL and zonulin levels (p>0.05). In addition, there was no significant difference between these markers and the histopathological stage of the patient group. Our study is the first study in the literature to compare serum NGAL and serum zonulin levels in children with celiac disease compared with the control group. Our findings prove that NGAL is an important component of inflammation in celiac disease. We suggest that serum NGAL and zonulin may be used as a biomarker in celiac patients. In order to evaluate the association of these markers with gluten-free diet compliance and the severity of pathological involvement, larger series of clinical studies are needed
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Çocukluk çağı gastrointestinal sistem hastalıklarında D vitamini düzeyleri
No full textGastrointestinal sistem hastalıklarında D vitamini eksikliğine farklı nedenlerle sık rastlanmaktadır. Bu çalışmanın amacıgastrointestinal sistemi ilgilendiren hastalıkları olan çocukların D vitamini düzeylerini incelemek ve D vitamini izlemigerektiren hastalık gruplarını belirlemektir. Mart 2015–Aralık 2016 tarihlerinde Çocuk Gastroenterolojisi polikliniğinde en az3 aydır izlenen ve D vitamini düzeyi belirlenen hastaların dosyaları retrospektif olarak incelendi. Çalışmaya toplam 294 hastadâhil edildi. Hastaların 138’i (%47) erkek, 156’sı (%53) kız idi. Hastaların ortalama yaşı 80,04 ± 65,24 (1-225) ay idi. Otuz birhastada (%10) D vitamini eksikliği (12 ng/ml) ve 57 hastada (%20) D vitamini yetersizliği (12-20 ng/ml) tespit edildi. Dvitamini eksikliği ve yetersizliği en fazla kış mevsiminde (sırasıyla %18 ve %29) yapılan analizlerde tespit edildi. D vitaminieksikliği ve yetersizliği en sık inflamatuvar bağırsak hastalığı, Gastroözofageal reflü hastalığı ve Çölyak hastalığı olanhastalarda tespit edildi. Yaş gruplarına göre en düşük D vitamini düzeyleri adolesan yaştaki hastalarda izlendi. Sonuç olarakçocuk gastroenterolojisi polikliniğinde adolesan yaştaki hastalar ile inflamatuvar bağırsak, çölyak ve gastroözofageal reflühastalığı olan çocukların D vitamini eksikliği açısından izlenmesinin yararlı olacağı kanısına varıldı
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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