1,721,801 research outputs found
GLUT1 was markedly enhanced in <i>VHL-KO</i> livers.
No full text<p>Expressions of GLUT1 (top panel) and GLUT3 (bottom panel), particularly GLUT1, are enhanced in <i>VHL-KO</i> livers. GLUT2 expression level in <i>VHL-KO</i> livers was comparable to that in the control livers (middle panel).</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Lung colonization profile of <i>B. pertussis</i> KO<i>caps</i>:<i>kpsT</i> and KO<i>caps</i>:<i>kpsMT</i> strains.
No full text<p>Balb/C mice were infected intranasally with 5×10<sup>5</sup> CFU of <i>B. pertussis</i> BPSM (solid bars), KO<i>caps</i> (striped bars), KO<i>caps</i>:<i>kpsT</i> (dotted bars) and KO<i>caps</i>:<i>kpsMT</i> (open bars). At the indicated time points, four infected mice per group were euthanized and their lungs were harvested, homogenized and plated on blood agar to determine the total number of CFU per lung. The results are expressed as the mean ± SEM of four mice per group. ** <i>p</i> value<0.01 relative to KO<i>caps</i>. Results are representative of two independent experiments.</p
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
<i>KO</i> islets accumulate oxidative stress, inflammation, and fibrosis.
No full text<p>(A) mRNA-Seq expression values for 25/368 of the mRNAs identified by Venn analysis (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002277#pbio.1002277.g003" target="_blank">Fig 3C</a>; right panel, underlined) that are reduced by <i>Ire1α</i> because of glucose that accumulates in the <i>KO</i><sup><i>Fe/-; Cre</i></sup> ([<i>n</i> = 5], [<i>p</i>-values ≤ 0.05]). (B) Oxidized lipid (hydroxyl-octadecadienoic acids, HODEs) from islets of the indicated genotypes infected with <i>Ad-Cre Ad-GFP</i> or no virus control ([<i>n</i> = 2; controls versus <i>n</i> = 3; <i>Ad-Cre</i>], [<i>p</i> = 0.00434]). (C) Antinitrotyrosine immunohistochemistry (IHC) of islets from 8-mo-old <i>WT</i><sup><i>Fe/Fe</i></sup> and <i>KO</i><sup><i>Fe/Fe; Cre</i></sup> mice 15 wk post-Tam with or without BHA diet for 3 wk. (Scale bar, 50 μm) (<i>WT</i><sup><i>Fe/Fe</i></sup> [<i>n</i> = 4 with BHA], [<i>n</i> = 5 regular chow]), (<i>KO</i><sup><i>Fe/Fe; Cre</i></sup> [<i>n</i> = 5 with BHA], [<i>n</i> = 6 regular chow]). (<i>p</i> = 0.00698; <i>WT</i><sup><i>Fe/Fe</i></sup> versus <i>WT</i><sup><i>Fe/Fe</i></sup> with BHA), (<i>p</i> = 0.04018; <i>WT</i><sup><i>Fe/Fe</i></sup> versus <i>KO</i><sup><i>Fe/Fe; Cre</i></sup>) and (<i>p</i> = 0.04420; <i>KO</i><sup><i>Fe/Fe; Cre</i></sup> versus <i>KO</i><sup><i>Fe/Fe; Cre</i></sup> with BHA). (D) Masson’s trichrome stain (blue) for collagens. Results demonstrate increased staining surrounding <i>KO</i><sup><i>Fe/Fe; Cre</i></sup> islets with haemotoxylin (red) and eosin (black) co-stains. Quantification of percent strong collagen stain is shown below the images. Scale bar, 50 μm. (<i>WT</i><sup><i>Fe/Fe</i></sup> [<i>n</i> = 4 with BHA], [<i>n</i> = 5 regular chow]), (<i>KO</i><sup><i>Fe/Fe; Cre</i></sup> [<i>n</i> = 5 with BHA], [<i>n</i> = 6 without BHA]). Percent strong collagen stain significance for <i>WT</i><sup><i>Fe/Fe</i></sup> without BHA versus <i>KO</i><sup><i>Fe/Fe; Cre</i></sup> without BHA <i>p</i> = 0.01049). (E) 8-mo-old male mice carrying the doubly floxed allele (<i>Ire1α</i><sup><i>Fe/Fe</i></sup><i>)</i> with and without RIP-Cre 12 wk post-Tam had their pre-BHA GTTs taken, and then half were fed the antioxidant BHA supplemented chow diet for 3 wk or not before examining the mice by GTT again. (<i>WT</i><sup><i>Fe/Fe</i></sup> [<i>n</i> = 11 with BHA], [<i>n</i> = 12 regular chow], [<i>p</i> = 0.035]), (<i>KO</i><sup><i>Fe/Fe; Cre</i></sup> [<i>n</i> = 18 with BHA], [<i>n</i> = 16 without BHA], [<i>p</i> = 0.041]). <i>P</i>-values were calculated by one-tailed student’s <i>t</i> test comparison of the areas under the GTT curves for the biological replicates of control group <i>WT</i><sup><i>Fe/Fe</i></sup> versus the Tam-induced <i>KO</i><sup><i>Fe/Fe; Cre</i></sup> group.</p
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
<i>VHL-KO</i> mice exhibit hypoglycemia despite normal glucose tolerance and intact pancreatic β cells.
No full text<p>(<b>A</b>) <i>VHL-KO</i> mice had significant decreases in blood glucose levels (BS) after tamoxifen injection (4 mg/mouse; n = 10). (B) <i>VHL-KO</i> mice were treated with streptozotocin (STZ) before or after <i>VHL-</i>knockdown (n = 4 per group). Before tamoxifen injection, STZ treated mice (blue line) had significant increases in BS compared with their pre-STZ-blood glucose levels. After tamoxifen injection, their BS gradually decreased (day 0 vs. day 7, *<i>p = </i>0.0057; day 7 vs. day 17, **<i>p = </i>0.036). The mice treated with STZ after tamoxifen injection (red line) did not show any significant increases in blood glucose levels throughout the experiment. (<b>C</b>) <i>VHL-KO</i> mice (<i>VHL-KO</i> tamoxifen +) had glucose tolerance results comparable to that of other mice (WT tamoxifen +/− and <i>VHL-KO</i> tamoxifen −): WT tamoxifen −, n = 11; WT tamoxifen +, n = 10; <i>VHL-KO</i> tamoxifen −, n = 11; <i>VHL-KO</i> tamoxifen +, n = 7. (<b>D</b>) Histopathological images of pancreatic tissues showed that the immunoreactivity patterns for insulin and glucagon and morphological changes were not affected by <i>VHL</i> deletion with comparable maximum diameters of islets between control (<i>VHL-KO</i> tamoxifen −) and <i>VHL-KO</i> mice. (<b>E</b>) Glucose tolerance tests showed similar trends in insulin concentrations between <i>VHL-KO</i> and control mice (n = 5 per group, Time 0 min, <i>p</i> = 0.773:N.S.; 30 min, <i>p</i> = 0.294: N.S.; 60 min, <i>p</i>>0.9999: N.S.). (<b>F</b>) Basal glucagon levels were comparable between <i>VHL</i>-<i>KO</i> and control mice (<i>p</i> = 0.465: N.S.).</p
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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