39,330 research outputs found
David Knowles (1896-1974)
No full textAubert Roger. David Knowles (1896-1974) . In: Bulletin de la Classe des lettres et des sciences morales et politiques, tome 62, 1976. pp. 91-96
Knowles (David) The English Mystical Tradition
No full textSéguy Jean. Knowles (David) The English Mystical Tradition. In: Archives de sociologie des religions, n°13, 1962. pp. 178-179
Monoposto racecar wheel aerodynamics: investigation of near-wake structure and support-sting interference
No full textMonoposto racecar development is routinely carried out using wheels supported not by the car
suspension but by individual, externally-mounted stings. The interference effect of these stings
was acknowledged but unquantified in the existing literature. Appraisal of the literature has
found that the structure of a wheel wake was not understood, rendering it difficult to assess the
support sting interference. These two issues were thus jointly addressed using experimental and
computational methods.
The two phases of this project each tested a different industrially-representative racecar wheel
model. Phase One investigated a single wheel and sting combination, whilst Phase Two extended
the work to include two further stings and a model racecar. Non-intrusive velocity measurements
were made in the near wakes of the various combinations to extract vertical planes, perpendicular
to the tunnel freestream.
The measurements made behind the isolated wheels were used to investigate the main flow
features of the wake. The flow surrounding an unsupported wheel was established computationally
and used to evaluate the interference effects of the support sting. Different wheel support
methods (three stings and the car suspension) were used to provide further insight into the sting
interference effects and also the impact of sting design on those effects. Testing with and without
the model racecar allowed evaluation of its effect on the wheel wake and sting interference.
The main characteristics of the near-wake of an isolated wheel rotating in ground contact are
proposed from analysis of the data generated in this study. A simplified model of the trailingvortex
system induced in the wake of such a wheel is proposed to clarify contradictory literature.
The specific interference effects of a wheel support sting are proposed with reference to the main
characteristics of the wake. The mechanisms behind these effects are, where possible, identified
and presented. The main impact of the support sting, and thus the root of several of the observed
effects, is the modification of the axial flow through the wheel.
The main effects of the presence of the car on the near-wake are proposed alongside the observation
that the wake structure is not fundamentally different to that of an isolated wheel. The
proposed sting interference effects are also observed in the presence of the car, albeit at a reduced
level
Knowles (David) The Historian and Character
No full textSéguy Jean. Knowles (David) The Historian and Character. In: Archives de sociologie des religions, n°16, 1963. pp. 182-183
James Knowles. Politics and Political Culture in the Court Masque. Basingstoke: Palgrave Macmillan, 2015. Pp vii, 288.
No full textThis review considers James Knowles. Politics and Political Culture in the Court Masque. Basingstoke: Palgrave Macmillan, 2015. Pp vii, 288
Dom David Knowles. Saints and Scholars
No full textCrépin André. Dom David Knowles. Saints and Scholars. In: Revue de l'histoire des religions, tome 166, n°1, 1964. pp. 93-94
Jean de Vignay, un traducteur du XIVe siècle
No full textKnowles Christine. Jean de Vignay, un traducteur du XIVe siècle. In: Romania, tome 75 n°299, 1954. pp. 353-383
The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition
No full textThe Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. We have determined the solution structure of Josephin and shown that it belongs to the family of papain-like cysteine proteases, sharing the highest degree of structural similarity with bacterial staphopain. A currently unique structural feature of Josephin is a flexible helical hairpin formed by a 32-residue insertion, which could determine substrate specificity. By using the Josephin structure and the availability of NMR chemical shift assignments, we have mapped the enzyme active site by using the typical cysteine protease inhibitors, transepoxysuccinyl-L-eucylamido-4-guanidino-butane (E-64) and [L-3-trans-(propylcarbamyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline (CA-074). We also demonstrate that the specific interaction of Josephin with the ubiquitin-like domain of the ubiquitin- and proteasome-binding factor HHR23B involves complementary exposed hydrophobic surfaces. The structural similarity with other deubiquitinating enzymes suggests a model for the proteolytic enzymatic activity of ataxin-3
Camp Greenleaf, M.O.T.C., Ft. Oglethorpe, Ga., Aug. 27, 1917
No full textCopyright claimant's address: Ft. Oglethorpe, Ga.Copyright deposit; Knowles & Head; August 25, 1917; DLC/PP-1917:45469
Knowles (M. D.) et Obolensky (D.). Le Moyen Age
No full textD'Haenen A. Knowles (M. D.) et Obolensky (D.). Le Moyen Age. In: Revue belge de philologie et d'histoire, tome 48, fasc. 1, 1970. Antiquité — Oudheid. pp. 94-97
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