1,721,070 research outputs found
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Superinfection dynamics of a clinically silent-novel EMA superfamily variant of the apicomplexan Theileria equi
Going Beyond Counting First Authors in Author Co-citation Analysis
The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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Characterization of humoral immune response in horses immunized with a recombinant Bm86 protein and challenge with Rhipicephalus (Boophilus) microplus tick
Babesia equi, has become a very important tick-borne parasite that is impacting the horse industry worldwide. As for both endemic and free areas, the presence of potential tick vectors capable to acquire and transmit the infection to naïve horses during mobilization, plays a very important role in Babesia equi transmission. The Rhipicephalus (Boophilus) microplus midgut protein Bm86 is a component of a partially protective anti-tick vaccine in cattle. However, whether Bm86-based vaccines also confer protection in immunized horses remained unknown. In this study we characterized the humoral immune response of horses immunized with rBm86 and challenged with Rhipicephalus (Boophilus) microplus larvae, as a preliminary step towards testing whether vaccination with rBm86 results in decreasing the fitness of Rhipicephalus (Boophilus) microplus in horses. Immunization was able to elicit a strong anti-Bm86 immune response with antibody titers between 1,000 and 10,000 at the time of tick challenge. Furthermore, characterization of the IgG sub-isotypes demonstrated a significant increase starting at week 3 after the first immunization in all IgG (T), IgGa and IgGb except for IgGc. IgG (T) was the most prevalent sub-isotype with titers greater or equal to 100,000, followed by IgGa and IgGb and not significant presence of IgGc at any of the analyzed time points. Horses from both groups, experimental and control were challenged with ≈ 2,500 R. microplus larvae per animal. Tick's feeding success, a way to assess the efficiency of the immunization, was evaluated measuring three different parameters, i.e. survival, tick weight, and eggs weight. The number of surviving ticks was significantly lower in the Bm86 group compared to the control group. No significant differences were observed either in ticks or eggs weight. All immunized animals, but one in the control group, developed a strong local skin inflammatory response in the areas where the ticks were feeding, likely interfering with the ticks feeding efficiency. Our results demonstrate that immunization with a recombinant Bm86 protein elicits a strong antibody response. However, under these experimental conditions and likely due to the strong inflammatory responses we are not able to confirm whether rBm86 immunization confers protection against tick's infestation in horses
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Eradication of Theileria equi from a ranch in Texas
In October 2009, Theileria (Babesia) equi infection was confirmed in a herd of domestic Quarter Horses on a large ranch in south Texas. There were 2,500 horses ultimately tested for equine piroplasmosis (EP) as part of the traceback and epidemiological investigation with a total of 413 T.equi-positive horses disclosed in connection with the outbreak. Active natural transmission of T. equi to horses on the index ranch was confirmed to have been occurring via Amblyomma cajennense and Dermacentor variabilis ticks. Epidemiological investigation and testing of the horses sold from the premises indicates that T. equi infection had been present in horses on the ranch since prior to 1990. The original source of the infection is likely to have been from longterm periodic movement of horses between the Texas ranch and another premises owned by the ranch and located in Brazil. The epidemiology and regulatory response to the outbreak is described which included extensive trace-back and testing of potentially exposed horses, longterm quarantine of infected premises, acaricide mitigation of tick vectors, culling of selected infected horses, and treatment of 163 T. equi-infected horses with a published high-dose imidocarb dipropionate protocol under the USDA-APHIS-VS and USDA-ARS EP treatment research program. The combined response measures ultimately resulted in successful eradication of T. equi from the index ranch. This is the only known outbreak of natural tick-borne transmission of T. equi on the U.S. mainland
Variations on the Author
“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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