199 research outputs found
'What the hell is wrong with you?' A corpus perspective on evaluation and emotion in contemporary American pop culture
No full textIn this chapter I take a corpus linguistic perspective on the language of evaluation and emotion working with a 1.5 million word corpus of American TV dialogue (from the TV series Gilmore Girls). I am interested in occurrences of evaluative and emotional phrases such as the following;1 y? LORELAI: Really. RORY: I don't believe this! Oh my God, I'm going to Chilton! 2 ce things were dirty . RORY: It's 7:16. LO RELAI: Oh my God, I wa s gonna wear my 3 ok this morning. Goo d morning, Jackson. S OOKIE: Oh my God, toda y was Rory's 4 s working. The phone is ringing.) LORELAI : Hey. Oh my God, you have good 5 s in my office if yo u'd like to see them. RORY: Oh my God, I to tally would. 6 is that? LANE: 12 calories. RORY: Here LANE: Oh my God bles s you! LANE: Man, 7 sit down. RORY: No I can't sit down. I'm too -- Oh my God, He k issed me! (Mrs. 8 Rich has this amazin g hair. RORY: Really? LANE: Oh my God, it's so perfect. It's 9 . (Emily takes a bit e and makes a face.) EMILY: Oh my God, it's horrible! What 10 ought we were meeti ng at Luke's. RORY: W e were? Oh my God, I'm so sorry. I 1 >LUKE: What the hell is going on? 2 >LUKE: What the hell is he terrified of? 3 CHRIS: What the hell are you doing here w ith my daughter? 4 LOGAN: What the hell is wrong with you? 5 >LUKE: What the hell is wrong with them? Why can't they just le t the bozo in 6 isbee! What the hell has gotten into you? LUKE: I told Rory we were e 7 RELAI: What the hell is that? 8 YPSY : What the hell are you doing here? 9 >LUKE: What the hell are we doing in a st eam room
Paleo-aridity records investigated through drip water chemistry in Lehman Caves, Nevada
No full textIn the Great Basin of the southwest United States, climate change is predicted to cause increased precipitation variability, making the future climate of the region uncertain. The paleoclimate record has direct examples of dramatic changes in water availability in this area, allowing for a comparison of precipitation changes and responses for the Great Basin. In Lehman Cave, Nevada, ten drips above actively-forming stalagmites were sampled monthly. Glass growth plates were also placed above three actively-forming stalagmites, allowing for the collection of new calcite growths. This project analyzed the samples for Mg/Ca, Sr/Ca, and U/Ca ratios to provide a comparison of the composition of calcite and the drip waters from which they precipitate. This will improve our understanding of the paleo-aridity of the Great Basin region, as well as provide useful context for the changing precipitation patterns expected with modern climate change.S.B
Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination
No full textThe emergence of novel SARS-CoV-2 variants led to the recommendation of booster vaccinations after Ad26.COV2.S priming. It was previously shown that heterologous booster vaccination induces high antibody levels, but how heterologous boosters affect other functional aspects of the immune response remained unknown. Here, we performed immunological profiling of Ad26.COV2.S-primed individuals before and after homologous or heterologous (mRNA-1273 or BNT162b2) booster. Booster vaccinations increased functional antibodies targeting ancestral SARS-CoV-2 and emerging variants. Especially heterologous booster vaccinations induced high levels of functional antibodies. In contrast, T cell responses were similar in magnitude following homologous or heterologous booster vaccination, and retained cross-reactivity towards variants. Booster vaccination led to a minimal expansion of SARS-CoV-2-specific T cell clones and no increase in breadth of the T cell repertoire. In conclusion, we show that Ad26.COV2.S priming vaccination provided a solid immunological base for heterologous boosting, increasing humoral and cellular responses targeting emerging variants of concern
Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development
No full textOpen Access funded by British Heart Foundation Under a Creative Commons license Acknowledgments Our thanks go to Gioia Polidori Francisco for training and discussions, Kate Watt and Yvonne Turnbull for technical and laboratory managerial support, Kadri Oras and Laura Ferguson for experimental support, Po-Lin So and Bruce Conklin (Gladstone Institutes) for providing their unpublished protocols, and Yukio Nakamura for discussion. This research is supported by the British Heart Foundation (PG/12/75/29851) and the Institute of Medical Sciences. A.S.B. was supported by the British Heart Foundation (FS/12/37/29516).Peer reviewe
The genesis of the Hunter Figure: A study of the dialectic between the biographical and the aesthetic in the early writings of Hunter S. Thompson
No full textHunter S. Thompson revolutionised American journalism in the 1970’s with the publication of ‘The Kentucky Derby is Decadent and Depraved’, in Scanlan’s Monthly, and ‘Fear and Loathing in Las Vegas’, in Rolling Stone magazine. Writing in a voice that was sui generis, his heavily subjective prose became known as Gonzo Journalism. For the next four decades he chronicled what he called the ‘Death of the American Dream’, whilst simultaneously building his own legend to mythic proportions. His fictive persona, the Hunter Figure, is central to his entire oeuvre, but to date, the body of critical analysis has largely diminished the role of his persona.This thesis, however, aims to address this critical imbalance by focusing on the origins of the Hunter Figure persona and the ensuing dialectic between the biographical and the aesthetic in the early writings of Hunter S. Thompson. Few other writers in contemporary American Literature have fused their own life and work to such an extent that the lines of differentiation between: author and character; fact and fiction; public image and private self, have become indistinguishable. Unravelling this complex web of interactions is therefore an essential task in order to fully appreciate and understand the primary motivations behind the creation of the Hunter Figure persona and in turn how this persona became the primary driver of the success of Gonzo Journalism.Through a chronological examination of Thompson’s career pre-dating Fear and Loathing in Las Vegas (1971), this thesis credits the persona for not only directly leading to the creation of Gonzo Journalism, but also for helping to establish Thompson as both a leading SuperFictionist in contemporary American Literature and a modern-day icon of American Outlaw mythology.N
Fixing Australia’s incredible defence policy
No full textAustralia’s new government must make tough decisions in defence policy. Australia’s broad national interests and the challenging strategic environment in Indo-Pacific Asia make it essential to modernise the Australian Defence Force. The nation’s defence capabilities remain underfunded and its strategic edge in the region is eroding. The gap between the nation’s interests and capabilities is widening, and it is getting harder to meet the demands of the US alliance. Australia’s new government needs to restore focus and funding to defence.Key findings: The Australian government will need a first-principles review to identify the military strategy and force structure required to protect and advance the nation’s interests. The Australian government must increase defence funding in order to modernise the Australian Defence Force\u27s capabilities. Otherwise it will need to make drastic cuts to planned defence capability. The government must also think deeply about the role of the US alliance in Australia\u27s security, and take the initiative in shaping that alliance in Australia’s interests
preferences for yeasts stable or contextual?
No full textWhether there are general mechanisms, driving interspecific chemical communication is uncertain. Saccharomycetaceae yeast and Drosophila fruit flies, both extensively studied research models, share the same fruit habitat, and it has been suggested their interaction comprises a facultative mutualism that is instigated and maintained by yeast volatiles. Using choice tests, experimental evolution, and volatile analyses, we investigate the maintenance of this relationship and reveal little consistency between behavioral responses of two isolates of sympatric Drosophila species. While D. melanogaster was attracted to a range of different Saccharomycetaceae yeasts and this was independent of fruit type, D. simulans preference appeared specific to a particular S. cerevisiae genotype isolated from a vineyard fly population. This response, however, was not consistent across fruit types and is therefore context-dependent. In addition, D. simulans attraction to an individual S. cerevisiae isolate was pliable over ecological timescales. Volatile candidates were analyzed to identify a common signal for yeast attraction, and while D. melanogaster generally responded to fermentation profiles, D. simulans preference was more discerning and likely threshold-dependent. Overall, there is no strong evidence to support the idea of bespoke interactions with specific yeasts for either of these Drosophila genotypes. Rather the data support the idea Drosophila are generally adapted to sense and locate fruits infested by a range of fungal microbes and/or that yeast-Drosophila interactions may evolve rapidly
Telecommunications policy in Turkey: restructuring for economic growth. European Policy Paper #11, November 2006
No full textIntroduction. Modern telecommunications technology is now widely seen as a critical driver in economic development. However, the issues involved in the rapid deployment of this technology are complex and frequently highly controversial. While some of these issues are technical, the most difficult ones involve changing a legal and regulatory framework which was originally designed for different times and different technologies. The process of changing this framework necessarily involves disruptive change for existing service providers as well as substantial benefits for the economy at large. This paper seeks to discuss these issues in light of Turkey’s progress to date in taking advantage of advanced available telecommunications technology and the myriad productivity-enhancing services that are associated with it.(1) An important element in developing a more competitive and dynamic sector in Turkey has been the desire of the country to become a member of the European Union. This has encouraged changes in the telecommunications regulatory regime following the guidelines set out in Chapter 19 of the EU “acquis” for candidate members. Nonetheless, substantial further efforts are needed to complete and implement the desired regulatory framework, particularly as it affects the former government monopoly carrier, Turk Telekom, and the cable companies. A further limiting factor has been an overall investment climate in Turkey which has been characterized by a high level of uncertainty for most investors, regardless of size or nationality. Policy recommendations to help accelerate the deployment of telecommunications technology include a clear reaffirmation of the government’s priorities for the sector, a reduction in the level of ownership and regulatory uncertainty, strengthening the Board and Staff of the Telecommunications Authority, and reviewing policies which reduce the scope and increase the cost of telecommunication licenses
Re-thinking residential mobility : linking lives through time and space
No full textRory Coulter’s work on this paper was partly supported by an Economic and Social Research Council grant [ES/L009498/1]. Maarten van Ham’s contribution was supported by funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007–2013) / ERC Grant Agreement n. 615159 (ERC Consolidator Grant DEPRIVEDHOODS, Socio-spatial inequality, deprived neighbourhoods, and neighbourhood effects); and from the Marie Curie programme under the European Union’s Seventh Framework Programme (FP/2007–2013) / Career Integration Grant no. PCIG10-GA-2011-303728 (CIG Grant NBHCHOICE, Neighbourhood choice, neighbourhood sorting, and neighbourhood effects). Allan Findlay’s work was supported by an Economic and Social Research Council grant [ES/K007394/1].While researchers are increasingly re-conceptualizing international migration, far less attention has been devoted to re-thinking short-distance residential mobility and immobility. In this paper we harness the life course approach to propose a new conceptual framework for residential mobility research. We contend that residential mobility and immobility should be re-conceptualized as relational practices that link lives through time and space while connecting people to structural conditions. Re-thinking and re-assessing residential mobility by exploiting new developments in longitudinal analysis will allow geographers to understand, critique and address pressing societal challenges.Peer reviewe
The efficient market hypothesis and a change to L.I.F.O. : an empirical study on the Johannesburg Stock Exchange
No full textBibliography: p. 250-271.The dissertation presents a discussion on the Efficient Market Hypothesis (EMH) with particular reference to the implications for Financial Reporting. Furthermore a conceptual framework is proposed for empirical research in accounting. The results obtained indicate a significant negative reaction to the announcement of a change to L.I.F.O, in the aggregate, which was shown to be directly proportional to the size of the impact on reported earnings. The relative risk of the firms was shown to be an intervening variable in that the low risk firms experienced a less severe negative reaction. It is concluded that the JSE is an inefficient market since the information is impounded slowly. As the market appears to be unable to look behind the accounting numbers, further evidence of inefficiency is apparent. Finally the thesis concludes that the JSE may be developing as the most recent reactions were less negative and far quicker, on aggregate
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