180,889 research outputs found
Reparatur von Klima- und Einzelraumheizgeräten : Kurzstudie zur Relevanz des Reparierbarkeits-Index (R-Score)
No full textDie Kurzstudie ist eine Entscheidungshilfe, um die potenzielle Einführung eines Reparierbarkeits-Index (R-Score) für Klima- und Einzelraumheizgeräte im Rahmen der Ökodesign-Richtlinie besser bewerten zu können. Das Ziel der Studie ist es, die Relevanz der Reparierbarkeit von diesen Gerätegruppen einschätzen zu können. Für die Ermittlung der Problemrelevanz wurde eine Befragung durchgeführt, sodass Stimmen von herstellenden Firmen und Verbänden, Großhandel, Installateur*innen, Handwerksbetrieben und Reparatureinrichtungen aufgenommen werden konnten. Die Autor*innen sprechen sich grundsätzlich bei beiden Produktgruppen für die Einführung eines Reparierbarkeits-Index aus und weisen darauf hin, dass für diese Produktgruppen die unabhängige Bewertung der Produktlebensdauer ein wichtiger Hebel ist, um die produktbezogenen Umweltauswirkungen zu reduzieren
Klimajugend – nur ein Mythos?
No full text80 Prozent der Jugendlichen machen sich große Sorgen um das Klima. 40 Prozent nehmen an, dass das Klima in zwanzig Jahren außer Kontrolle ist. Aber nur gut die Hälfte will sich für das Klima engagieren. Warum
Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates
No full textPathological modifications in the microtubule-associated protein Tau is a common characteristic observed in different neurological diseases, suggesting that analogous metabolic pathways might be similarly affected during neurodegeneration. To identify these molecules and mechanisms, we utilized Drosophila models of human Tau-mediated neurodegeneration to perform an RNA interference functional screening against genes considered to be implicated in the pathogenesis of different neurodegenerative disorders. We found that the downregulation of the Drosophila REEP1 homolog protein enhanced Tau toxicity with increased formation of insoluble aggregates. On the contrary, the overexpression of either the Drosophila or the human REEP1 protein was able to revert these phenotypes and promote neuronal resistance to ER stress. These studies identify a new function for the REEP1 protein in vivo and a novel cellular mechanism to prevent Tau toxicity
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
System quality management in company IMPROMAT KLIMA spol. s.r.o.
No full textBakalářská práce se zabývá systémem řízení kvality v podniku IMPROMAT KLIMA spol. s r. o. V teoretické části se autorka zaměřila na popis managementu jakosti a na jeho historii. Dále se práce věnuje jednotlivým ISO normám, zabývající se problematikou řízení a kontrolování kvality a také normám s tím související. Praktická část bakalářské práce analyzuje daný podnik a popisuje normy, které se v podniku používají. V poslední části práce autorka provádí zhodnocení implementovaných norem a podává doporučení.Bachelor project is deal with system quality management in IMPROMAT KLIMA spol. s.r.o. company. In theoretic part is specialized to description quality management, and its history. Further project description individual ISO standarts, conversant problems management and controlling of quality and standarts connecting with this. Practical part analyse company Impromat Klima, description its standarts, which in the company use. In last part author practise implementation standarts and feed introduction.Ústav ekonomieobhájen
Immunoprecipitation for Protein-Protein Interactions and for RNA Enrichment in Drosophila melanogaster
No full textTo determine the molecular and functional interactions between RNA-binding proteins (RBPs) and their targets RNAs, is of fundamental importance to understand the dynamic organization of the nervous system in health and disease. Nevertheless, this task has remained elusive due to the lack of specific protocols and experimental systems that would allow the combination of biochemical analysis with in vivo functional genetics. In this manuscript, we describe a trustworthy and detailed methodology to establish the molecular organization and intracellular function of RBPs/RNA multimeric complexes in a cell type-defined manner by using the powerful GAL4/UAS system for gene expression in Drosophila melanogaster
TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity
No full textBackground: Mutations in the small RNA-binding protein TDP-43 lead to the formation of insoluble cytoplasmic aggregates that have been associated with the onset and progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting homeostasis of the motor system which is also characterized by aberrant expression of retrotransposable elements (RTEs). Although the TDP-43 function was shown to be required in the neurons and glia to maintain the organization of neuromuscular synapses and prevent denervation of the skeletal muscles, the molecular mechanisms involved in physiological dysregulation remain elusive. Here, we address this issue using a null mutation of the TDP-43 Drosophila homolog, TBPH. Results: Using genome-wide gene expression profiles, we detected a strong upregulation of RTE expression in TBPH-null Drosophila heads, while the genetic rescue of the TDP-43 function reverted these modifications. Furthermore, we found that TBPH modulates the small interfering RNA (siRNA) silencing machinery responsible for RTE repression. Molecularly, we observed that TBPH regulates the expression levels of Dicer-2 by direct protein-mRNA interactions in vivo. Accordingly, the genetic or pharmacological recovery of Dicer-2 activity was sufficient to repress retrotransposon activation and promote motoneuron axonal wrapping and synaptic growth in TBPH-null Drosophila. Conclusions: We identified an upregulation of RTE expression in TBPH-null Drosophila heads and demonstrate that defects in the siRNA pathway lead to RTE upregulation and motoneuron degeneration. Our results describe a novel physiological role of endogenous TDP-43 in the prevention of RTE-induced neurological alterations through the modulation of Dicer-2 activity and the siRNA pathway
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Vorwort
No full textRammstedt O. Vorwort. In: Fuchs-Heinritz W, Klima R, Lautmann R, Rammstedt O, eds. Lexikon zur Soziologie. Opladen: Westdeutscher Verlag; 1973: 7-10
- …
